ACell, a Current Review of Applications in Hair Transplant Surgery

[gmonasco]

Hairtalk is spot on - you have to ask yourself why companies are not pouring investment into Histogen, why isnt this company on the news? Shouldn't their phase I have been worldwide coverage?

If they stick to the original plan, the investment should come after the phase 1 trials are complete:

[IMG]http://www.************/hair-loss/img/uploaded/2879_image215.jpg[/IMG]

[UK_]

Have they? I thought HSC was currently in phase 1 trials.

They are in "Phase I/II" which means they are still testing the safety element associated more commonly with Phase I studies, Dr Ziering shall have some results for the hair loss community in the coming weeks, some 'exploratory studies to determine dosage arrangements for Phase II in spring this year'. I believe these are 50 patients receiving initial doses of the HSC, it usually takes 3 months before the first effects become noticable from a clinical perspective, I highly anticipate these, we also still have Aderans who are deeply entrenched (200+ subjects) in Phase II. We may hear from them later on in the year (September/October).

[HairTalk]

Have they? I thought HSC was currently in phase 1 trials.

I could be mistaken, but I think Histogen is beginning phase-2 clinical testing of H.S.C.

[gmonasco]

Truthfully, Histogen's H.S.C. has completed stage 1 trials — most drugs that pass stage 1 testing go on to fail by stage 3.

Have they? I thought HSC was currently in phase 1 trials.

[gmonasco]

One thing about Histogen's H.S.C.: as I said, I feel this prospect could be fruitful, but, I'd much like to see before–after shots of H.S.C. treatment of a bald area. Show me a few square inches of bare scalp, then that same area with even a dozen hairs (not "vellus hairs") growing out of it — without transplantation — and I promise you I'll get excited

Indeed. Otherwise, there's no telling how much of the measured increase in hair count might have been existing hairs that were simply coaxed out of the telogen phase rather than new hairs.

[UK_]

And true hair multiplication is still well over a decade away, it's so easy to get caught up in the current hype. I'd say 15 - 20 years we will have something, not a cure, but something, those banking on a cure in 2015 are dreaming.

[UK_]

I feel — if it doesn't turn out to promote neoplasia or something (I don't think it will, and I hope it won't) — H.S.C. could be used alongside hair-transplantation and finasteride (or instead of finasteride, for those reluctant or unable to use it) to ward off further hairloss. To whether the effects of H.S.C. will be permanent, I can't say (and I don't believe anyone yet can); to its efficacy and patient-factors that may influence this, I also cannot say.

Therein lies my only concern.

[HairTalk]

@HairTalk - do you not believe there is a 'slightly elevated' chance that being as though BOTH Histogen and Aderans are actually entering Phase II trials now, that we 'may' see a 'better treatment' in the near future?

I am not talking about a cure (NW7 - NW1) I am referring to a better treatment, it has been noted that the vast array of compounds that fall within the c47% failure rate amongst those that have already passed phase I are not usually biotech procedures/compounds but more commonly, traditional chemical based medicines.

I feel — if it doesn't turn out to promote neoplasia or something (I don't think it will, and I hope it won't) — H.S.C. could be used alongside hair-transplantation and finasteride (or instead of finasteride, for those reluctant or unable to use it) to ward off further hairloss. To whether the effects of H.S.C. will be permanent, I can't say (and I don't believe anyone yet can); to its efficacy and patient-factors that may influence this, I also cannot say.

[RichardDawkins]

But it doesn't matter how effective the treatment is, trials do not always fail on the basis of the compound being ineffective lol.

I am not bothered at all about the effectiveness of HSC, I know it works.

Hairtalk is spot on - you have to ask yourself why companies are not pouring investment into Histogen, why isnt this company on the news? Shouldn't their phase I have been worldwide coverage?

You see thats my point, some things are just plausible if you think about them, and thats my driving engine here :-)

Companys will pour their money in, when the successfully leave the first phase thats for sure.

But the problem is, hairloss is only interesting to a small scale of people you know and its not considered life threatening and thats our only "problem" here.

But i say in all honesty and with deep respect, "Dr Hitzig please provide more pictures, it doesnt matter if the results are not bombastic, because improvement is everything :-)"

[UK_]

@HairTalk - do you not believe there is a 'slightly elevated' chance that being as though BOTH Histogen and Aderans are actually entering Phase II trials now, that we 'may' see a 'better treatment' in the near future?

I am not talking about a cure (NW7 - NW1) I am referring to a better treatment, it has been noted that the vast array of compounds that fall within the c47% failure rate amongst those that have already passed phase I are not usually biotech procedures/compounds but more commonly, traditional chemical based medicines.

[HairTalk]

become somthing very good.

To me, everything involving more hair (except an transplant) is a cure.

Of course in the 90s those rumors like 10 years from now, were preset but i bet that those "cures" were real sci fi stuff and right now a lot of different research companys come up with plausible stuff which to me is believable.

You know what do i loose when iam optimistic and there wont be a cure (highly unlikely)?

- I didnt loose anything at all because in th end i can get a hairtransplant if it comes to this, but i didnt waste any time with depressions

But what did i loose when iam optimistic and there is a cure (very likely)?

- yes i gained double time

--------------------------

If iam pessimistic and no cure?

- Lost precious time to live and no cure

Pessimistic and cure? Depressions will still remain even with a cure around

----------------------

Self-proclamations always are of "optimism" or "realism"; I doub't anyone ever will challenge your sentiment by boasting he's a "pround pessimist." The point is not whether you should be hopeful, but that there simply is not, as yet, compelling evidence that "the cure is around the corner." What basis have you for claiming the "high likelihood" one will be found? What supports such a probability: the fact that "people are working on it"? I, too, hope it happens, but it's unfounded to suggest the statistical probability it will.

By the way, you say, "To me, everything involving more hair (except an transplant) is a cure"; you must realize, even if ACell pans out, it will, indeed, be a transplant-dependent accomplishment.

One thing about Histogen's H.S.C.: as I said, I feel this prospect could be fruitful, but, I'd much like to see before–after shots of H.S.C. treatment of a bald area. Show me a few square inches of bare scalp, then that same area with even a dozen hairs (not "vellus hairs") growing out of it — without transplantation — and I promise you I'll get excited — .

[UK_]

around 100 new hairs on 2 square centimeters of scalp with only the histogen test injection......if people consider this bad well i advise you to see a shrink immediately..

But it doesn't matter how effective the treatment is, trials do not always fail on the basis of the compound being ineffective lol.

I am not bothered at all about the effectiveness of HSC, I know it works.

Hairtalk is spot on - you have to ask yourself why companies are not pouring investment into Histogen, why isnt this company on the news? Shouldn't their phase I have been worldwide coverage?

[RichardDawkins]

around 100 new hairs on 2 square centimeters of scalp with only the histogen test injection......if people consider this bad well i advise you to see a shrink immediately.

I dont know if you guys read the story about thie PVt guy who had i belive plucked hairs injected in his scar and he said almost all of them grow and so far it looked good. And this guy is someone who is really one pessimistic and drastic son of a bitch ( in a good way, this is meant respectful by me)

It is highly likely that a cure will come in the near future, yes stem cells are present in your scalp and this is a hope bringer, if you can manipulate or kickstart them, your worrys are finally over for good.

I wasnt around during the 90s but i think most of the cure talk was utter bullcrap even compared to those 90s standards.

Btw Tricho is not gone for good they recruited some people for their studies, some user here posted a link. Strangely it seems that they are playing the under the radar thing.

[UK_]

...Optimism is nice, but hopes that scrape the heavens are likely to shatter to shit if they fall. ..

LOL exactly, Histogen is the only process ive ever held confidence about, and even that is only in Phase I Asian c/t -

The best news in a long while for me was the existence of the stem cells in bald scalps - and that they were still producing microscopic hairs, I think optimism is nice aswel, and does hold some value, no matter how negative I am about the whole baldness research field I have this inert feeling deep within that we will reach the finish line 'someday', but at a guess I would say we are well over a decade off.

However in defence of Histogen, the issue of the WNT7A and its induction of follicular neogenesis has been in the literature for well over a decade, w/ proven efficacy in animal models.

[RichardDawkins]

You see three different opinions and thats a good thing, i like it. I give it the benefit of believing because with a little bit more effort this can become somthing very good.

To me, everything involving more hair (except an transplant) is a cure.

Of course in the 90s those rumors like 10 years from now, were preset but i bet that those "cures" were real sci fi stuff and right now a lot of different research companys come up with plausible stuff which to me is believable.

You know what do i loose when iam optimistic and there wont be a cure (highly unlikely)?

- I didnt loose anything at all because in th end i can get a hairtransplant if it comes to this, but i didnt waste any time with depressions

But what did i loose when iam optimistic and there is a cure (very likely)?

- yes i gained double time

--------------------------

If iam pessimistic and no cure?

- Lost precious time to live and no cure

Pessimistic and cure? Depressions will still remain even with a cure around

----------------------

So thats just me and if you dont like it then its your problem ;-) i dont try to convice you guys to be optimistic.

Yes Dr Hitzig should blew out more well documented pictures but on the other hand its good that someone tries something to help hairloss sufferers.

So i stick with the stupid little thing called "Hope" and remain happy