ACell, a Current Review of Applications in Hair Transplant Surgery

[RichardDawkins]

Dr Cole no one is attacking you but i personally think that you will be one of the first docs to get something with hair cloning done for the patoents and even if its some form of Ghos HST.

The reason for this is simple, you keep on learning therefore i dont attack you for changing your opinions from time to time. I think those changes of mind are much more important then the same old clinic statements " Hair multiplication is impossible and will maybe available in 10 to 20 years"

I would really prefer your clinic to get in touch with Gho and if the evidence is good, to offer HST done by yourself, because i like your work and i think that your reaults with an way expanded donor will be more then just amazing, but thats my opinion

[UK_]

The last post was a general post to the rest of the community - Wesley Sneijder had a HST procedure with Gho, his results look great, I have also seen pictures of his donor, granted from a distance but I see no thinning as he keeps his hair shaved grade 2.

[John P. Cole, MD]

UK, what is this link to?

I don't think it is impossible to clone hair. i just think it is more difficult than our present state of research can manage.

I've not seen any of Dr. Gho's patients in many years. I honestly can't comment on the work he is doing today. We spoken by phone in the past. He's a nice man. I know that his donor areas looked good and the grafts had a good yield though the grafts were not placed at a high density yeas ago.

I'm not familiar with Dr. Bernstein's comments on follicle growth. i do know that he forms opinions and once formed, they are difficult to modify.

You could well be correct about Aderans. They are an enormously successful company. There is no doubt that it will be in their best interest financially to find a solution to inducing follicle growth. The same can be said for Histogen. My primary point is that I don't expect the breakthrough to come from Aderans, ever though i wish them all the success in the world. My other point was that the example Histogen gave did not appear to be the same place on the scalp. That made me skeptical about Histogen. It seems they have other results that look more impressive, however. You guys are giving me some good information and I'm processing it. I really appreciate the feed back. It is helping me to better formulate my opinions. Thanks.

[UK_]

Dr Gho's procedure pwns all FUE clinics.

http://www.6park.com/news/messages/33777.html

[UK_]

Dr Cole don't you think it is just typical that Dr Bernstein/Rassman have both stated it is near impossible for a follicle to be grown in vitro - and a year later German scientists totally proved them wrong? lol.

Rassman has also been attacking Gho's procedure - sorry but as a consumer if I had £10,000 to spend on a surgical procedure what would I spend it on? regular FUE or HST (or head tattoo lmfao)? Bear in mind I personally have never seen an FUE doc produce donor results/pictures similar to the ones seen by Dr Gho.

[UK_]

I'm not attacking Bosely commercials or suggesting that their research is not real. Why wouldn't someone want to find a cure for hair loss with medication? you'd make even more millions. what i'm saying is that while they might have a financial inducement to produce clinical results, their total marketing package might be to include a hair research center that is not properly funded in an effort to add credibility to their brand. How else do you get over the hurdle of 30 years of bad work? You add credibility in other ways. Aderans is Bosley. Why did they hire Ken Wieshnik? He added credibility; he certainly knew very little about hair transplants. He knows alot about Propecia and other hair loss drugs, but that's his strength. Aderans is not trying to clone hair. They are trying to create cell multiplication. No one has found a solution to this yet, either.

If your theory is true, then why has Aderans been acquiring past small biotech companies that were working with primarily DP cells? (I.e. Intercytex).

Why bother if it's just a marketing scam?

I am sure there are better ways to overcome bad press than spending millions on adulterated clinical trials... McDonalds found a great way - buy out Subway sandwiches and sell to the health conscious that way.

By the way Dr Cole - I doubt if [for arguments sake] Aderans were to be found out about this proposed marketing scam, it wouldn't be the consumers that would be angry due to being fooled into believing Bosley are better than they are (rolf), you would see a massive investor backlash, lawsuits would run riot - sorry, but I can't see it.

Dr Bernstein is a great guy - and so is Dr Rassman... but here is another individual who proposed the utter impossibility of growing a hair follicle outside the lab... low and behold a year later our friends in Germany grew a fully functioning hair follicle (Lauster et al).

[John P. Cole, MD]

Hair Talk, we will try to do a better job in the future to satisfy your photographic needs. In the meantime, we are promoting hair transplant surgery, a proven entity. We are not trying to raise speculative dollars selling a technology like Histogen. Histogen is held to a higher standard because their technology is not proven. They need perceived results to fund a round of speculation from their investors. Most of their investors do not have the experience that someone like myself has to analyze their photographs and recognize that the photos are inconsistent with the pre-operateive photos. Maybe you would give them a million dollars to further investigate these unimpressive photos, but I would not and i would not encourage any of my friends to invest in a unproven technology.

In general, we have far more results than we post. We don't post as many as we have simply because we have always felt that patients hold us to a higher standard. If it looks good, but does not meet our standard, we will not post it. If there are obstructing things like hair clips hiding the results, we will not post them. With over 10,000 hair transplant procedures, I can assure you that I have many more results than i post. Of course only a limited number of patients allow their photographs to be posted, but even then we allow only those patient results that are fair and balanced to be depicted on our website over the course of time. Anyone can change the lighting to make a result look better. That's not our modus operandi.

Having said all this, i would put our results up against what I've seen from Histogen 7 days a week.

Regarding blurry, i don't like that. i like clean and crisp. I think you need to be able to focus on a result. i've seen far to many results that were not clean and crisp to the point that you cannot magnify them. I've always felt this was important and i will speak with my webmaster to insure that we do not deviate from my personal standards. Of course you can't always insure that patients send you the highest quality pre-op or post-op photos, but you can ensure that you post the highest quality images to your webslte. We've done this in the past. i don't micromanage my non-surgical staff, but I also don't allow anything other than perfection. In my surgery room I have my eye on everything Outside it, I can only evaluate what was done such as photographs. Sill given that our only photographs are of the highest standards and we cannot control photographs that patients send us, I honestly feel that you are maliciously over reaching in your comments, Hair Talk. There are far more clinics with obvious suboptimal photographs, but you have singled mine out. What is your objective? How could you compare my results to those of Histogen, when those of Histogen are nothing short of misleading?

[Havok]

the results look pretty good to me, but i suspect it's because the patient was a good HT candidate judging by his pre-op photo.

[HairTalk]

All i can say is that the results on their website are not impressive. If i were promoting a product, i'd put more impressive photos on my website.

Sorry, Dr. Cole, but most of the images on your own Web site are anything but impressive or revealing; often, they're blurry, shaky, low-resolution pictures. Sometimes, they're just odd and ridiculous glamor shots:

[mlao]

Not sure about the other results regarding histogen. All i can say is that the results on their website are not impressive. If i were promoting a product, i'd put more impressive photos on my website.

This is a statement I agree with 100% never before has so much hope been pinned on so little photo evidence.

that said I hope I'm 100% WRONG!

[John P. Cole, MD]

Boy, I'm getting hammered with good questions. I'll try to answer them, but may have to refer back to the questions and do a continuation.

First, i don't know what Dr. Bernstein is doing. He has a clever mind as Dr. Cooley. I'd like to know.

Second, Wnt proteins do all sorts of things. They even cause cancer. With mice, you can toss any research in the waste bin because mouse hair does not respond like human hair. Interesting, but they need to show me human results. You can rub a nude mouse and it might grow hair. You already know you can't do the same on your scalp.

Wnt has been around for some time and smart people have been studying it in relation to hair growth for a number of years. The people i know have not come up with any new revelations.

I'm not attacking Bosely commercials or suggesting that their research is not real. Why wouldn't someone want to find a cure for hair loss with medication? you'd make even more millions. what i'm saying is that while they might have a financial inducement to produce clinical results, their total marketing package might be to include a hair research center that is not properly funded in an effort to add credibility to their brand. How else do you get over the hurdle of 30 years of bad work? You add credibility in other ways. Aderans is Bosley. Why did they hire Ken Wieshnik? He added credibility; he certainly knew very little about hair transplants. He knows alot about Propecia and other hair loss drugs, but that's his strength. Aderans is not trying to clone hair. They are trying to create cell multiplication. No one has found a solution to this yet, either.

Not sure about the other results regarding histogen. All i can say is that the results on their website are not impressive. If i were promoting a product, i'd put more impressive photos on my website.

[mlao]

In my opinion, Aderans keeps their search for a cure to hair loss in progress simply to add credibility to their mass marketing TV approach. In today’s society, quite honestly, if you need to market your medical services on TV, you really don’t have a strong reputation. Having a research center helps give them credibility, but they’ve produced nothing so far. I’m not putting my money behind Aderans. I hope I’m wrong, but I just can’t get behind them.

Dr Cole are you implying that they are advertising future hair cloning in television commercials?
I doubt the layman watching a Bosley commercial would connect them with Aderans cloning research.
I have never seen Bosley ever mention hair cloning.

[UK_]

http://www.famigliacristiana.it/famiglia/news/dossier/calvizie-la-soluzione-dalle-staminali_270711152804.aspx

(Google translate).

Also... How old is this: http://www.accessexcellence.org/WN/SUA06/bald.php (?)

Although his work did not involve hair diseases, biology Prof. Robert Hoffman of the University of California-San Diego – who founded the oldest freestanding biotech company, AntiCancer, in the city 27 years ago – had fascinating things to say. He has spent years researching stem cell markers in the brain that were called Nestin. Incredibly, Hoffman discovered them in abundance in human and murine hair follicles. They can differentiate into neurons, muscle cells and others, and thus “could eventually become an easily accessible source of adult stem cells to produce new organs – even to repair spinal cord injuries.”

With hair, the sky is the limit, and it’s all in your head.

Comments on 15th Annual Meeting of the European Hair Research Society (EHRS) (2011)

From here:

http://www.jpost.com/ArtsAndCulture/Entertainment/Article.aspx?id=229673

(last paragraph)

[UK_]

What is causing the red color at the top of the before photo that is more prominent in the right upper quadrant? Where are the two follicular units inside the circle in the after photo? Either the two areas are different or Histogen had a negative affect on these two follicular units.

What happened to the red color. Could this red color indicate that something other than androgenic alopecia was causing the hair loss on the top of the photo?

Dr Cole, thank your for your opinion.

The larger pictures of the scalps of the individuals involved in the study clearly showed classic male 'pattern' hair loss.

Dr Cole, would you also suggest the results of Mayumi Ito to be equally wrong? Through the use of wnt proteins Mayumi Ito and his team were able to restore grey hairs to their original colour and also saw growth of new hairs.

http://www.telegraph.co.uk/science/science-news/8581231/Breakthrough-could-make-grey-hair-a-thing-of-the-past.html

How do you respond to this?

I personally also, simply do not believe Histogen are trying to pull the wool over our eyes here, such a contention really demands factual evidence.

Is there something you know that we dont?

[Follicle Death Row]

I'll be keeping a good eye on Wesley Sneijder's hair. It's looking damn good so far and he's certainly a good advert for Dr. Gho's HST.