another hope : 3D printed comb for hairloss

[hairbear]

Hi guys
I cannot translate this so maybe one of you would like to try ; basically its a new 3D printed hair comb designed by technicon students in israel.this new technology uses synthetic biology method to penetrate skin. It will be presnted at the igem exhibition in Boston .
Worth following progress.

http://article.yedioth.co.il/Default_mob.aspx?articleid=9733

I cannot use Google translate. Perhaps one of you can try

[lacazette]

Hey hairbear, thank you!

The fact that it's coming from Technion make it extremely interesting!!

"The students will allow the drug | Photo: Elad גרשגורן
Tired of מהקרחת? Introducing the new solution להתקרחות from the Technion. A group of students from Technion will close September world igem competition in Boston, ארצות־הברית, new drug name will show one of world's most common problems among men. Developers, students first degree from Technion, סינתטית cell users, as that explain Yael, presenting us with a visit to the drug lab. "this solution completely different than what is currently available on the market, there are a lot of drugs for which unfortunately cause beyond measure which measures among men.

Israeli group of Technion, accompanied by Roy Amit, competitor for the third contest. The group ten ingredients first degree students at Technion: Alex, Roni, liron, Yael, tal and richest - faculty of לביוטכנולוגיה ולמזון, and when spring from the Faculty of chemical engineering from a bud ושגיא power machines. "for a year we are working on developing new formula ההתקרחות problem with men", explains a fountain. "The method is based on our innovative biology סינתטית."

Technion have already made so many inventions, that thing could be really really promising

Do you live in israel dude? Please keep us update if you see more infos

[hairbear]

I am an Israeli living in Cape Town SA
I am subscribed to all Israeli health news channels and will definitely follow up and will update here.
Google translate gave an idea of what was written but didn't translate the part where they use synthetic biology for this process and as far as I understand they use the shell of a dead virus to penetrate the follicle and inside the shell they store some blocker .
This is what I pick up . on t big on science stuff.
If the are successful in Boston we will all know about it .

[JayM]

Hey hairbear, thank you!

The fact that it's coming from Technion make it extremely interesting!!

"The students will allow the drug | Photo: Elad גרשגורן
Tired of מהקרחת? Introducing the new solution להתקרחות from the Technion. A group of students from Technion will close September world igem competition in Boston, ארצות־הברית, new drug name will show one of world's most common problems among men. Developers, students first degree from Technion, סינתטית cell users, as that explain Yael, presenting us with a visit to the drug lab. "this solution completely different than what is currently available on the market, there are a lot of drugs for which unfortunately cause beyond measure which measures among men.

Israeli group of Technion, accompanied by Roy Amit, competitor for the third contest. The group ten ingredients first degree students at Technion: Alex, Roni, liron, Yael, tal and richest - faculty of לביוטכנולוגיה ולמזון, and when spring from the Faculty of chemical engineering from a bud ושגיא power machines. "for a year we are working on developing new formula ההתקרחות problem with men", explains a fountain. "The method is based on our innovative biology סינתטית."

Technion have already made so many inventions, that thing could be really really promising

Do you live in israel dude? Please keep us update if you see more infos

My head hurts after reading this haha. So like what's the difference from other useless combs?

[hairbear]

My head hurts after reading this haha. So like what's the difference from other useless combs?

According to tgr article the comb is being used as a vehicle for the medicine. It helps it get to the follicle.The medicine itself is something compldetly new. They don't reveal much info but I guess we will see more articles about this new technology in the near future .

[JayM]

Surely they must have had to do a clinical trial for it? Is there a clinical trials page for Israel?

[lacazette]

Yes sounds like a new drug, and a better vehicle to directly target the follicles. So it's sounds really interesting.

And especially when it's coming from the Technion Institute, it could be huge in my opinion

[joachim]

we're not talking about pilox, right? because pilox was said to also origin from the technion. and we all know that pilox is scam or at least a useless product so far.

so this 3d printed comb is something different?
and if it's a comb, why does it habe to be 3d printed?

hairbear, as native Israeli, wouldn't it be possible for you to reach out to those guys, to find out more details?

[lacazette]

"Technion-Israel Institute of Technology is one of the most important centres of knowledge and innovation in the world.
for Technion-Israel Institute of Technology, which is ranked among the world’s leading science and technology universities."

8 of some inventions from technion: (article: http://notable.ca/8-life-changing-in...u-should-care/ )

. Memory Sticks USB Flash Drive
You’ve lost at least 12 of these. Invented by Technion alumnus Dov Moran, M-systems

. Ziv-Lempel Data Compression Algorithm
Whether you know it or not, you use this everyday. Think: PDF, JPG, TIFF, PNG, and ZIP file formats. Oh, and this data compression algorithm has also come in handy for our friends at NASA.

. Azilect
For treating early-stage Parkinson’s, this medicine was developed by Profs. Moussa Youdim and John Finberg at the Rappaport Faculty of Medicine together with Teva Pharmaceuticals

. A Breath Test for Cancer Diagnosis
Yes, you read that right. Thanks to Hossam Haick this checkpoint gives a whole new meaning to the word breathalyzer. He is now taking it a step further by incorporating this technology with smartphones. That’s right, a phone that can sniff out cancer

. ReWalk Robotics
Amit Goffer, a Technion grad and CEO of ReWalk Robotics, designed a robotic suit that enables paraplegics to walk, drive, and (seriously) even run marathons.

. Instant Messaging/ICQ

. Pill Cam
This is a pill with a camera inside that can be swallowed and projected to a screen allowing doctors to see inside a patient’s intestine. Turns out you are what you eat.

. InSightec
A surgery that uses non-invasive ultrasound to replace the surgeon’s knife through the innovative determination of Technion graduate, Dr. Kobi Vortman.


Hey Joachim , it's clearly not pilox as they're talking about a new drug here and 3D printing
And as I remember the inventor of pilox was a former technion student/professor, that was not a technion program

[JayM]

Does anyone speak hebrew/arabic who can email these guys? Maybe see if we can get a proper English translation on what it actually is?

[lacazette]

Ok I find the infos, on the igem exhibition website.

Here is their team registration page for the event :

http://igem.org/Team.cgi

And when you click on "about our project form", you'll get that : http://2015.igem.org/Safety/About_Ou...t?team_id=1674

"The main goal is to degrade DHT (Dihydro-testosterone), which causes male baldness. We are planing to do this by cloning the 3-alpha-HSD gene () from Rat liver origin into E.Coli and B.Subtilis. This enzyme converts the substance into it's inactive and safe form.

We plan that the bacteria will be applied onto the scalp with a special comb.

How would your project be used in the real world?
In a consumer product that ordinary people buy

Regular lab strains: E.Coli: top10, DH5alpa, BL21
B.Subtilis: PY79


There's also on the page the names of the 5 instructors and the 10 students

[joachim]

Ok I find the infos, on the igem exhibition website.

Here is their team registration page for the event :

http://igem.org/Team.cgi

And when you click on "about our project form", you'll get that : http://2015.igem.org/Safety/About_Ou...t?team_id=1674

"The main goal is to degrade DHT (Dihydro-testosterone), which causes male baldness. We are planing to do this by cloning the 3-alpha-HSD gene () from Rat liver origin into E.Coli and B.Subtilis. This enzyme converts the substance into it's inactive and safe form.

We plan that the bacteria will be applied onto the scalp with a special comb.

How would your project be used in the real world?
In a consumer product that ordinary people buy

Regular lab strains: E.Coli: top10, DH5alpa, BL21
B.Subtilis: PY79


There's also on the page the names of the 5 instructors and the 10 students

ok, so they trick the E.coli into producing a new enzyme which degrades the DHT. this sounds exactly like what we need finally!
if this would work with a vehicle like the follicept gel this would truely be a revolution in prevention of MPB.
BUT: could it also have a positive effect on bald skin, too? if you constantly remove the DHT from the miniaturized follicles over many months or even a whole year, would they come to life again?

[JayM]

Do we know how far along they are? and yeh the E.coli has been modified so that it produces the enzyme to break down DHT. I assume the comb is needed because its an organism so I'm not sure how that will work with follicept. And who knows about the miniaturised follicles. The only time I've seen a nw5 go to nw2 is in transgenders. But I've always thought we have got to a point now where you can inhibit almost all DHT with dutasteride - And I still see people lose hair.

[lacazette]

ok, so they trick the E.coli into producing a new enzyme which degrades the DHT. this sounds exactly like what we need finally!
if this would work with a vehicle like the follicept gel this would truely be a revolution in prevention of MPB.
BUT: could it also have a positive effect on bald skin, too? if you constantly remove the DHT from the miniaturized follicles over many months or even a whole year, would they come to life again?

Yes it could sound huge, if this works, it could mean no more DHT in all our follicles. And the 3D printing they're talking is for the perfect vehicle to bring that killer anti dht bacteria into our follicles.

I hope as you questioned, that it will be capable to help miniaturized to grow back again, but even if not, it will be great also for big Norwoods who want to go the transplant route, and in the future in combination with SM/piloscopy/histogen, etc

I'm a severe Norwood 4, so if that thing work, and could really slow the baldness, It could convince me to go for a more aggressive HT, and not be scared to become a Norwood 7 in a few years. It could save a lot of us for some years, and help waiting more peacefully the neogenesis cure hehe

[joachim]

but wait, they're not going to inject the bacteria itself. the bacteria (e.coli) is used to generate the new enzyme in large amounts, so that the enzyme itself can be injected into the scalp. an enzyme is practically a cluster of different molecules, relatively large in size.
IGF1 (from follicept) is also made by e.coli. those little bacterial bastards are just used as biological work horses ;-)

would be interesting for how long these enzymes can last in the scalp, or if they are transported from the blood and going systemic. then of course, we would have the problem that the DHT dissappears from other regions in the body as well. that would be a bad sideeffect. but we don't know nothing about it yet. let's see