another hope : 3D printed comb for hairloss

[lacazette]

"Thangapazham and colleagues have shown de novo hair follicle neogenesis in skin substitutes made entirely with cultured human cells.
This major advance in skin regeneration is predicted to improve skin stability, healing and ultimately lead to a viable clinical strategy for restoring hair."

So at least we know that the invention in the patent will be tried for hair treatment.
the skin tissue for soldiers will come fast, so we will know soon if they have successfull follicular neogenesis as they claimed. And if it's the case, the "cure in 5 years away" could become a reality. Cause it's speculation, but as these methods/compositions for follicular neogenesis are being tested before in FDA clinical trials for military use, doesn't it mean that when it will be for civil use, they won't have the needs to do longer and every of the 3 phases? Cause if it's approved for soldiers, that would mean cancer safety data, etc would be already solved no?

In japan they say a treatment can now have an approval after 2/3 years of clinical trials, instead of 7/10 years before, and without sacrifying safety.
I hope the 21st century cure bill could do not as much as in japan but at least take out 2 or 3 years of the old FDA approval timeline

[Renee]

I think he has the same issue of gene expression that dr christiano & dr jahoda encountered. It says in his brief bio that I posted on the other page: "In 2015 he was selected by the Dermatology Foundation to receive a Career Development Award to study genes regulating hair follicle neogenesis, growth, and development." So my hunch is he received money to study the final phase of how to get 100% gene expression.

[Renee]

Lacazette, there is absolutely no safety issue with this method here. This method can not cause cancer or tumors, these are your own cells and there are no growth factors added. The ips cells are the ones that can cause cancer or tumors.

I think the better treatment would be bioengineering hair follicles in the lab and then transplanting into the scalp. Dr lauster team claims they can create 10,000 hair from 30 biopsies and also dr tsuji was able to do this in 2012. I wish we could could know what they are up to now.

[champpy]

this thread quickly fell behind, but let me ask....

Is this "3D comb" treatment something that these students are theorizing may work, or is this an actual product they plan to take to market?

I cannot find much about this and from what I am reading I just don't know what to make of it. I don't see that it was tested and shown to be effective. Hell actually I don't know why the comb would even have to be 3D printed. Why not just fill a normal comb applicator with whatever miracle they supposedly have found?

Does anyone know if this is moving forward or if this is just a "science fair" project that these students are coming up with?

[lacazette]

The team will participate at the world igem competition in Boston in september.
Even if they don't win, they will have visibility, if they not already partenering with someone in Israel.

As I remember with their technology you can target directly the follicle with a molecule in a virus/vehicule , anthing like that, and so would mean suppress 100% dht around the follicle, or soon put SM, seti, etc directly

that could be really great, we will know more after the competition in september, or we could try to contact the team members, to ask little things, if they have a commercial plan ,etc. They are Young they will answers the mails hehe

[JayM]

The team will participate at the world igem competition in Boston in september.
Even if they don't win, they will have visibility, if they not already partenering with someone in Israel.

As I remember with their technology you can target directly the follicle with a molecule in a virus/vehicule , anthing like that, and so would mean suppress 100% dht around the follicle, or soon put SM, seti, etc directly

that could be really great, we will know more after the competition in september, or we could try to contact the team members, to ask little things, if they have a commercial plan ,etc. They are Young they will answers the mails hehe

I would be happy to email but can't find anything?

[lacazette]

Hey jay thanks, i'll do some too, here is their name, if we Google them with "mail" "contact" we will find some :

Team Roster

Instructors
Roee Amit
Beate Kaufmann
Alexey Tomsov
liron abrahami


Student Members
Josef mualem
Sigal Kroitoro
Itay Naor
Moran Shapira
May Merav
Chen Machal
Iftach Vicrobizki
Matar Rosen
naseeb saida
Fady Badar
Loai Absawy


Others
Atid Tal Neeman
Efratd Efrat ziv Duvshani

[joachim]

The team will participate at the world igem competition in Boston in september.
Even if they don't win, they will have visibility, if they not already partenering with someone in Israel.

As I remember with their technology you can target directly the follicle with a molecule in a virus/vehicule , anthing like that, and so would mean suppress 100% dht around the follicle, or soon put SM, seti, etc directly

that could be really great, we will know more after the competition in september, or we could try to contact the team members, to ask little things, if they have a commercial plan ,etc. They are Young they will answers the mails hehe

is the competition public?

[lacazette]

I don't know Joachim, they talk about guest attendance , it means the need of an invitation no?

September 24 - 28 -- Hynes Convention Center -- Boston
With no regionals, all participants are invited to the Giant Jamboree to present their accomplishments and compete in front of a global audience.
See details about the event, including information on guest attendance, at 2015.igem.org/Giant_Jamboree.

[burtandernie]

This thing feels to me like one of those things invented in the lab that will never make it to the public and might or might not ever amount to anything. Lots of new things just dont turn out for various reasons even if they do work better than existing things.

[champpy]

But i still dont understand the competition aspect of this. Have they already tested it and will show results in boston? I mean theres been lots of theories on hair loss but not alot of actual treatments. They would have to show this actually works to win a competition wouldnt they?

[lacazette]

But i still dont understand the competition aspect of this. Have they already tested it and will show results in boston? I mean theres been lots of theories on hair loss but not alot of actual treatments. They would have to show this actually works to win a competition wouldnt they?

You're right, it would sound weird to try to win a competition with just a "theory method".
I really think they successed with their method to suppress 100% of the DTH in hair follicle, but in mouse lol or maybe in human we don't know, maybe some of the students could answer us.

If it really work , it is sure that it will go for commercialization ( the problem is how many years). In the team page registration , they say their invention is "for large public daily use"

and those quotes from them confirm for me that they work with a commercial vision

""for a year we are working on developing new formula ההתקרחות problem with men", explains a fountain. "The method is based on our innovative biology סינתטית."
""this solution completely different than what is currently available on the market, there are a lot of drugs for which unfortunately cause beyond measure which measures among men."

Technion has made great inventions, this one could be useful for us

[dutchguyhanging]

ok guys i think i need to step in as a supply chain analyst working in one of the big 3 pharmas. All these years, one thing i learned is that funding is the LAST thing you should worry about. if you can demonstrate what you are saying, I guarantee you that a hour later ur phone will ring and 10M offer will be on the table. all you have to do is just show what you are saying. I swear 10M eur is nothing for this

[youngin]

All this time and everyone here is still so convinced its all about DHT. Its silly really.

1) You cannot CONSTANTLY destroy all localized DHT to your hair follicle. The chemical will get into your blood stream, and will spread.
2) You cannot destroy all DHT without destroying 5AR, which Finasteride can already do at high doses. And guess what happens when you destroy all 5AR+DHT for an extended period of time? I'm sure the thousands of negative testimonies online will qualify as evidence.
3) Destroying DHT will only slow down the process, it will not reverse baldness. You can cut your balls off and still not reverse it completely, because it is not the destructive force.
4) The best REGROWTH agent we have (minoxidil) has nothing to do with DHT!!!

Most people here are looking at the wrong medication type for a cure... its not going to happen as time has told. We CAN destroy nearly all DHT in your body already, guess what... its not going to cure you. Then you have people with some of the best regrowth results I HAVE EVER SEEN (PrettyFly83) growing tons of hair with Minox and a roller. That has absolutely nothing to do with DHT!! It has everything to do with resurfacing his skin and getting rid of fibrosis.

GET OVER IT PEOPLE

[baldybald]

All this time and everyone here is still so convinced its all about DHT. Its silly really.

1) You cannot CONSTANTLY destroy all localized DHT to your hair follicle. The chemical will get into your blood stream, and will spread.
2) You cannot destroy all DHT without destroying 5AR, which Finasteride can already do at high doses. And guess what happens when you destroy all 5AR+DHT for an extended period of time? I'm sure the thousands of negative testimonies online will qualify as evidence.
3) Destroying DHT will only slow down the process, it will not reverse baldness. You can cut your balls off and still not reverse it completely, because it is not the destructive force.
4) The best REGROWTH agent we have (minoxidil) has nothing to do with DHT!!!

Most people here are looking at the wrong medication type for a cure... its not going to happen as time has told. We CAN destroy nearly all DHT in your body already, guess what... its not going to cure you. Then you have people with some of the best regrowth results I HAVE EVER SEEN (PrettyFly83) growing tons of hair with Minox and a roller. That has absolutely nothing to do with DHT!! It has everything to do with resurfacing his skin and getting rid of fibrosis.

GET OVER IT PEOPLE

Exactly. The sad part is that some people in this forum are so excited about silly stuff like dermarolling and bimatoprost and other stuff that will not be a game changer. This is hairloss and that means it needs something tricky to solve it. Human body is so complicated and so far nobody understand the reason of hairloss even though we are close to 2016. The truth is always painful and sad