US government owned patent on hair follicle neogensis

[lacazette]

Omg look at that other quote dudes

[089] The invention also provides a pharmaceutical composition comprising human dermal papilla cells and human keratinocytes, optionally in combination with collagen, for use in treating a subject who is at risk for, diagnosed with, or who has hair loss or is in need of hair follicle neogenesis



!!!

And this one explains what do they mean when they used the expression "morphologically correct" :

"hair follicles that have a normal configuration with an epithelial filament coming out of the distal end of the follicle and dermal papilla sitting at the base of the follicle. The follicles also have ceils proliferating at the base of the follicle, and have concentric layers of outer and inner root sheath, cuticle and cortex.
The follicles exhibit normal differentiation of the outer root sheath, and have hair shafts and sebaceous glands. The hairs go through normal cycles, and contain an epithelial stem cell component"


Am I dreaming guys??? ))

[Sogeking]

Yeah this is military first patent was filed in 2011. And this is just a patent not sure if the skin that is written about in the patent is actually that functional.

However this might come to market in a few years or two decades. They are not in a hurry to commercialize it.

[lacazette]

The first patent is from 2011, and explain what they will need for functional skin graft. (made any claims)

The second patent is deposed on May 1, 2014, and they explain in details how their compositions/methods fills these needs

[JayM]

Plus they said that they are in clinical trials using this patented technology.

[Renee]

Sogeking, how do you know they are not in a hurry to commercialize it? Or did you just make that up? There are thousands of soldiers that need this cure for quality of life.

[JayM]

The lead scientists email is: rajesh.thangapazham@usuhs.edu I have no idea what I'm really asking haha. Does anyone with a better understanding want to see if we can get anything?

[lacazette]

From articles about army skin regenerative developpment

"This type of technology is particularly pertinent for the US military, as burns account for 30 percent of injuries endured by soldiers on the battlefield. Add to this, the number of soldiers who are surviving previously fatal injuries; there is now a renewed effort to develop innovative treatments to improve the care of injured service personnel.

"“One of the most urgent requests from both burn patients and their care providers is to eliminate the need for (previous) skin grafts.”

"“Severe burns can ruin a life, so there is a desperate need.”

Yes renee I think also it will go fast for burned disfigured soldiers, and then for civil ones.
Their methods for hair loss sufferers will come later, but not that much, since the major issues about FDA things will be already resolved.

We are really Lucky, cause as they said, the most crucial point that was missing for a new functional skin was the hair follicle neogenesis that induce normal HF.
So US army research worked exactly on the point that we, hair loss sufferers, needed

@Sogeking just read again and keep cool

[089] The invention also provides a pharmaceutical composition comprising human dermal papilla cells and human keratinocytes, optionally in combination with collagen, for use in treating a subject who is at risk for, diagnosed with, or who has hair loss or is in need of hair follicle neogenesis

[lacazette]

The lead scientists email is: rajesh.thangapazham@usuhs.edu I have no idea what I'm really asking haha. Does anyone with a better understanding want to see if we can get anything?

good jay! we could ask him simple questions or confirmations on some details. I doubt he will answer but it costs nothing hehe I will try tomorrow

[TooMuchHairWontKillYou]

Will it be a pill or some kind of surgery?

[Sogeking]

Sogeking, how do you know they are not in a hurry to commercialize it? Or did you just make that up? There are thousands of soldiers that need this cure for quality of life.

I am not questioning the need for this for hair follicle neogenesis, or even the benefit or making new skin itself. It would be much needed not just to soldiers.
However the last patent has been filed in 2014. This is what it says:

This invention was made in part with support from the U.S. Government. Accordingly, the Government has certain rights in this invention.

We have no idea when the Government will move and allow creation of a company(startup) to commercialize this. Also I was referring to skin itself, they did move hair follicle grafts but they used skin substitutes not skin itself as noted:

Skin Substitutes: Three-dimensional in vitro constructs were prepared for grafting using established methods modified as described herein. Briefly, human dermal papilla cells were mixed with 1 mg/ml type I collagen (rat) (in other embodiments, the collagen could be bovine) in 10% FBS/DMEM, and added to 6 well transwell plates (Corning Incorporated, Coming, NY) at a density of 1 .5 X 105 cells per cm2. The dermal equivalents were cultured in 10% FBS/DMEM for 4 days before aliquoting 1 X 106 keratinocytes on top. The constructs were cultured submerged for 2 days in a mixture of DMEM and Ham's F12 (3:1) (GIBCO/lnvitrogen, Grand Island, NY) containing 0.1 % FBS, after which the keraiinocytes were brought to the air-liquid interface and cultured in a mixture of DMEM and Ham's F12 (3:1 ) containing 1 % FBS for another 2 days before grafting.

That said what we really miss, at least what I miss are tables at the end which are not visible at the link given. That said they did get some notable results:

Figs. 16A-C show that different hair follicle stages could be detected in grafts after 15 weeks. The grafts containing dermal papilla cells grown in monolayers, and those grown as spheroids, had telogen hair follicles, confirmed by club-like appearance and spiky keratin fibers (see Fig. 16A), secondary hair germ with adjacent hair papilla (see Fig. 16B, arrow), and a cornified club (see Fig. 16C, negative for toluidine blue staining, arrow). Telogen hair follicles showed no Ki-67 positive cells, consistent with telogen stage of hair follicle (Fig. 17A, arrow). An anagen hair follicle (Fig. 17B, arrow) with dermal papilla from the same section as the telogen hair follicle shows dense Ki-67 reactivity in matrix, as expected.

However they are still taking human dermal papilla cells and implanting them into bald rats. This is all early stage research. As I said 2-20 years we can't really know. If it were a commercial company they would have incentive to get the funds and rush it to be approved by FDA.Since the US government is involved we don't know in what manner or speed things will progress from lab to market.

[lacazette]

Guys!!!
they are enrolling people RIGHT NOW for a MPB trial!!!!!

Study Using a Topical Investigational Medication for the Treatment of Male Pattern Hair Loss

http://www.wakehealth.edu/BeInvolved...70&title=Study Using a Topical Investigational Medication for the Treatment of Male Pattern Hair Loss

OMFG

[Hemo]

Just curious, how do you know that's the same treatment? Pages 2 and 3 of the thread won't load for me.

[Renee]

Oh wow! Wake forest is one of the institutions that is involved with usa government in researching regenerative medicine. I wonder if this trial has to do anything with any of the patents?

[lacazette]

Oh wow! Wake forest is one of the institutions that is involved with usa government in researching regenerative medicine. I wonder if this trial has to do anything with any of the patents?

For sure in my opinion dude!!the military medical institutions are collaborating and are all under US Army research entitie. I'm sure those findings in these patents help to lead to that beginning trial !

@hemo :

"[089] The invention also provides a pharmaceutical composition comprising human dermal papilla cells and human keratinocytes, optionally in combination with collagen, for use in treating a subject who is at risk for, diagnosed with, or who has hair loss or is in need of hair follicle neogenesis"

[lacazette]

Renee
guess who was a participant of the 'Regenerative Medicine Essentials' organised by Wake Forest in 2013?
yes the answer is Rajesh Thangapazham! ^^

"Rajesh Thangapazham @RAJ_SR · 21 juil.
Started #rmessentials"

My god I wish I live near them to participate this trial! Sounds promising as hell