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Head donor is immune to MPB. No need to resort to beard.NW7 can find 75 mpb resisten grafts.
Nigam took this NW7 guy and he will cluture 3dcells, how we know he wont use beard hair and body hair to convert this guy to nw1...dr umar do this all the time.
I want Thane. Pure Nw7 dude.Comment
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I think the use of beard hair as a source of DP cells was Boldy's idea. And I think it's actually a good idea. But again, it's an experiment, nobody knows if it will work. This is what Boldy said about it:
The use of beard hair dp's (that is never been tried as far I know), could be a game changer. DHT/androgens work as a Growth stimulation in this case, and its pretty giniuse to make use of this property.
Its known that Human scalp disassociated Dp cells, or even fresh isolated intact dp, are found hard to induce Folliculogenesis, while mice disasociated dps are easier to culture, and promote Folliculogenesis even as disassociated cells when combined with epithelial cells.
To override this problem, there have been found, that aggregated dissociated cells (a sphere), restores the dp markers, and are able to induce Folliculogenesis.
My expectation is that beard dp cells, (maybe even disassociated cells) are better at promoting Folliculogenesis.
the idea is to get the mixture in the miniaturized follicles.
I do know and believe that cell therapy is the only cure.
in aga scalp, the dps over express AR's, while in safe zone not.
Beard dp's are know to reactive positive on by androgen exposure.
I expect this combo Beard dp's + the anagen expressed growth factors, could open a new door. (read well "Could").Comment
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By Dr Nigam from HS:
[div][postedby]Originally Posted by drnigam[/postedby]
kindly find below pics of Mr.Joshi , 38 yr old , a case of NW7 who has been wearing wigs since last 4-5 yrs .We intend to convert him to NW2 (implantation of about 15000 grafts,if he responds to HM too, he would be lucky )
with the following protocol in coming months :
1) day 0 - (5th October 2013)
75 grafts were extracted from his beard and sent to our biotech lab for isolation of hair stem cells and dermal papilla cells.
We will wait for minimum 30 days to have good number of above cells to be injected into the bisected grafts .We have sealed the beared holes with growth factors and extra cellular matrix hence there will not be any white dots ,we may get hair regeneration at the beard too , definitely with future injection of multiplied progenitor hair stem cells and multiplied DP cells.
2) day 1 - (5th November 2013) ,day 2 (6th November ), day 3 ( 7th November ), day 4 ( 8th November )
On day 1 to day 4 we intend to extract 80- 90 % of his donor hair .
Do an in-vitro doubling , where in we bisect the follicle under magnification and implant one bisected part and the recipient and the other at the donor scalp .
At the same time , we will inject growth factors , multiply progenitor stem cells , 3D spheroidal multiplied dermal papilla cells , extra cellular matrix and concentrated PRP .
3)day 5 (23rd December 2013 )
Repeat injection of multiplied progenitor (CD 200+ ) hair stem cells , 3D spheroidal dermal papilla cells , growth factors and ECM plus balance 20% donor left after first session will also be extracted .
4)day 6 ( 30th January 2014)
Repeat injection as mentioned in day 5 plus doubling of whatever new grafts which would have grown back
5) day 7 ( 10th March 2014 )
Repeat injection as mentioned in day 5 plus doubling of whatever new grafts which would have grown back
6) day 8 (15th april 2014)
Repeat injection as mentioned in day 5 plus doubling of whatever new grafts which would have grown back . Remember anytime if the stem cells and DP cells are exhausted in the lab , new 75 grafts will be taken from the beard for the same .
7) day 9 ( 10th May 2014)
Repeat injection as mentioned in day 5 plus doubling of whatever new grafts which would have grown back.
8) day 10 (10th June 2014)
Repeat injection as mentioned in day 5 plus doubling of whatever new grafts which would have grown back.
Remember the above protocol is chosen since the patient is a localite from Mumbai , if someone is from outside Mumbai we would have called him for four days per session, 6 months apart to save on number of visits for the patients who are NW7 .
The protocol and the number of visits may change if the person is ready to wait to see the results of pure hair multiplication for 7-8 months if the patient responds to HM nothing else to be done , if the patient does not respond he would have to go back to doubling .NW2/3/4 may require 2-3 visits .
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
extraction of approx 75 beard grafts for culturing stem cells and dermal papilla cells.
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
click link below to see enlarged close up of the above pic
http://drnigams.net/images/js/large/13.jpg[/div]Comment
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WE WANT THANE! WE WANT THANE! Come on everybody, chant with me! WE WANT THANE! WE WANT THANE!Comment
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We do not make the kids now, this is another good case of Nw 6-7.
Mr. Joshi would be a bad candidate for a transplant.
If - when they have finished work - will have a good combing and does not show, then it means that Nigam has a cure.
Also, by no sane person would invent all this to make some extra money, especially now that a chirugo as Mwamba (member IAHRS) and Spencer are on him.
If he wanted to cheat he could stay in India or in any case would not have consented to such testing.
Just wait, doing constructive criticism!Comment
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To be fair that guy is pretty baldComment
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Man, I don't know. These pictures are extremely blurry. What happened to his pro photograph ? This picture is just horrible: http://www.drnigams.net/images/js/large/6.JPG I can shoot a better one with my phone !
It's tough to see where his hairline ends. Yes, the picture surely gives the impression he's a NW7, but man, I don't know. We really need better pictures than this.
Also, to make the case more credible, please ask this patient to show us a few photo's he shot in the past. Preferably with longer hair and it would be really great if he could supply a few photo's from when he was a few years younger too. That would help a LOT with credibility.Comment
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Yeah perhaps. I doubt Nigam will do that though.
Even so, if he can get this guy to a (reasonably) dense nw2 I will be pretty impressed. Annoying that the treatment will continue till next summer though, so even if this guy stays for the entire duration and gets results, we won't see the full extent of them till almost a year from now.Comment
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When I went for my treatment with HASCI, I had to send them pictures in the first place, before even going there. That seems like normal procedure right ? I don't see why this guy can't supply us a few pictures of the past. These pictures show his face already, why wouldn't he do that ? And it would give the case a LOT more credibility.Comment
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It actually makes me angry. If this is the best quality photo's Nigams can make, then just please stop. Just stop man. You're not going to convince anybody with a blurry 1 megapixel photo.Comment
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Not seeing what are you talking about? That picture is the back of his head, it makes it very clear, as do others, that he is extremely bald. There is no debating that, it's made clear from the pictures. We could stand to do with a little more brightness but lets not be ridiculous, the man has no hair line, thats abundantly clear from the side view pics http://www.drnigams.net/images/js/large/3.JPGComment
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