RepliCel Reports Progress on Shiseido Technology

[hellouser]

Could this really be available in 3 years?

3.25 years... but yeah.... it looks like the deregulation will make that possible. See chart below:

[hellouser]

*edit*

[john2399]

Could this really be available in 3 years?

[hellouser]

Does anyone know if the cell culturing really takes 5-8 weeks?

[joachim]

sounds good. and also the fact that studies/trials and some cell culturing stuff is done in western countries like germany and austria gives me a good feeling. tells me they are not messing around and have serious science behind it. in the interview they also talk about a new location in toronto... something for you hellouser =)

replicel sounds more and more promising, although at least 3 years away.

[hellouser]

Latest interview with David Hall:

http://www.replicel.com/replicel-treating-functional-cellular-deficits-an-interview-with-ceo-david-hall/

This part is interesting:

We were interested in doing a geographic license for Japan and parts of Asia for three main reasons. The first was to have a third party validation of our science and technology which is always important to a start-up company. The second was to be partnered with a large company whom had the resources (both human and financial) to conduct their own clinical program which along with our program would more than double the data being collected as we work towards establishing our dosing and other protocols for the technology in humans. Thirdly, Shiseido has committed to cell therapy in a significant manner including having commissioned and now opened a purpose-built cell processing centre in Kobe Japan, in the heart of the country’s regenerative medicine initiative.

[PrettyFly83]

English version:

http://www.shiseidogroup.com/releimg/2289-e.pdf

[hellouser]

I don't know Hellouser.

How could they have possibly had significantly better results than Aderans when researchers such as Jahoda and Christiano and Gerd and Lauster have not even figured out how to protect inductivity yet?

One thing I will say however is that since Dr. Aaron Gardner has indicated that some of the inductivity is inside the cells and some of the inductivity is inside the environment, this means that researchers do not necessarily need to preserve 100% of inductivity in cell culture since some of the inductivity is not even found in the cells. I think that Dr. Aaron Gardner said that scientists have achieved preservation of 40% inductivity in cells so that may be sufficient since for all we know the other 60% could be found inside the environment.

Now about the environment, that almost certainly includes adipose stem cells or some component thereof. And there is not even a working model yet for how to combine 3d culture of appropriate hair cells + adipose stem cells. Dr. Aaron Gardner says they are just now beginning testing that but can not say anything publicly about that yet. There is nobody who says anything publicly about it yet so Replicel and Shisheido can't possibly be using such complicated combination models like this yet.

I really don't think that either replicel or Shisheido are able to produce a breakthrough cell treatment yet. I think that it will be another year before researchers have cracked the code and until researchers crack the code I don't see how either Replicel or Aderans can commercialize a breakthrough cell treatment.

I think before we come to conclusions like this we should first find out if they're culturing the cells in 2D or 3D. If in 3D.... well then... good times may be ahead of us.

[nameless]

Jesus... commercialization? So... they had positive results? What would be the point of building the facility if the results were no better than Aderans?

I don't know Hellouser.

How could they have possibly had significantly better results than Aderans when researchers such as Jahoda and Christiano and Gerd and Lauster have not even figured out how to protect inductivity yet?

One thing I will say however is that since Dr. Aaron Gardner has indicated that some of the inductivity is inside the cells and some of the inductivity is inside the environment, this means that researchers do not necessarily need to preserve 100% of inductivity in cell culture since some of the inductivity is not even found in the cells. I think that Dr. Aaron Gardner said that scientists have achieved preservation of 40% inductivity in cells so that may be sufficient since for all we know the other 60% could be found inside the environment.

Now about the environment, that almost certainly includes adipose stem cells or some component thereof. And there is not even a working model yet for how to combine 3d culture of appropriate hair cells + adipose stem cells. Dr. Aaron Gardner says they are just now beginning testing that but can not say anything publicly about that yet. There is nobody who says anything publicly about it yet so Replicel and Shisheido can't possibly be using such complicated combination models like this yet.

I really don't think that either replicel or Shisheido are able to produce a breakthrough cell treatment yet. I think that it will be another year before researchers have cracked the code and until researchers crack the code I don't see how either Replicel or Aderans can commercialize a breakthrough cell treatment.

[hellouser]

hellouser, isn't this the same news you posted on page 2, post no. 24?

Ah yes... theres so much info that I often forget, lol.

[joachim]

Jesus... commercialization? So... they had positive results? What would be the point of building the facility if the results were no better than Aderans?

hellouser, isn't this the same news you posted on page 2, post no. 24?

[hellouser]

April 21, in the Kobe Medical Industry Development, Shiseido Co., Ltd. "(SPEC, pepper spec) Shiseido cell culture processing center" has announced it will open on May 1 a. In the facility, it is the core of research and development to commercialization of hair regenerative medicine, the culture and processing of cells.

http://www.qlifepro.com/news/2014051...er-opened.html

Jesus... commercialization? So... they had positive results? What would be the point of building the facility if the results were no better than Aderans?

[Artha]

April 21, in the Kobe Medical Industry Development, Shiseido Co., Ltd. "(SPEC, pepper spec) Shiseido cell culture processing center" has announced it will open on May 1 a. In the facility, it is the core of research and development to commercialization of hair regenerative medicine, the culture and processing of cells.

http://www.qlifepro.com/news/20140511/shiseido-kobe-do-hair-regeneration-medicine-research-and-development-cell-culture-center-opened.html

[Artha]

I assume they would want to go to commercialization ASAP

You bet!

[Sogeking]

Folks you clearly have not been paying attention if you think this is the problem.

1 replicel had results in their phase 1/2A trials that cannot be marketed

2 however, in an episode of the bald truth last year, spencer declared he had a call with Hall, replicel CEO, in which the latter declared they are moving along with different approaches. Furthermore, they had results relating to a later time point from the original trials that were promising

3 the bottom line is they are likely to be doing phase 2B with improved knowledge acquired in phase 1/2A. They will release initial results from 2B at some point in 2015 or 2016 (I can't remember but it's on the website).

4 In the meantime the Japanese will do their own trial in japan subject to Japanese regulation. This is what we have to look forward if we can find more information about it. I don't know if the Japanese of Sheiseido have to start over from phase 1 but if they are intentioned to make progress they are probably about to be starting (or have already started, more likely) their own trials. They have all tube money and research power to carry on serious efforts so I assume they would want to go to commercialization ASAP

Hope you are right man. I really do. I'm keeping my fingers crossed.