Sept 2012 patent: Natriuretic Peptides shows terminal hair growth in weeks

[Dees Dab]

So you think RU with BNP would be a very good combo?

Time will tell.

Frank, I'm wondering if KERATENE with BNP maybe a good combo?

[frankzukini]

Also, people should be educated about the difference between estrogenic fat deposits (pseudogynecomastia), gynecomastia (growth of glandular tissue) and plain fat. I'll let you do your own Googl'ing.

[frankzukini]

Do you think RU could be the culprit behind a drop in libido?

Of course, antiandrogens can lead to hyposexuality, this is a known fact; there's no distinction between androgen receptors in the scalp and elsewhere, AFAIK. I'm no endocrinologist, but here's a hypothesis. My understanding is that a loss of libido is caused by androgen deficiency whereas gynecomastia is caused by an excessive action of estrogens, mainly due to an increase in the estrogen to androgen ratio. The fact of the matter is that it is quite unlikely to significantly increase this ratio by using an androgen receptor antagonist (ie. there will be a slight increase in free androgens, leading to an increase in estrogen production (ratio stays similar; slightly more estrogens; slightly higher activity)). While using finasteride, conversion of testosterone to DHT (much, much higher affinity to androgen receptor; higher biologicial activity) is inhibited (drastic reduction of androgenic activity), leading to an increase in free testosterone causing 1. a decrease in testosterone production, 2. a significant increase in estrogen production and 3. a higher conversion to estrogen via the aromatase enzyme. Hence, finasteride would be much more likely than RU58841 to cause gynecomastia and other sexual side effects, since, respectively, the estrogen to androgen ratio would skyrocket, when using a 5-alpha-reductase inhibitor, and the androgenic activity would crash. I'm sure it's much more complicated than that, though, but I'm at least convinced RU58841 may cause the same side effects as finasteride, but is much less likely to do so, espcially if you occasionally take a day off to free those receptors.

This is going off topic.

[Conpecia]

You should read my post, which is 3 posts before your own.



AFAIK, the conclusion forumers made out of BNP-32's study is that BNP-32 induces the growth of vellus hair which are expected to grow into terminal hair in a "normal" time frame (approx. a year). I've never started rubbing this chemical on my scalp thinking I'd have hair transplant like results in 2 weeks, it'd be completly foolish. There's no significant progress to report on my side, at this point.



I would be so much more worried about your finasteride. Gynecomastia is caused by the action of estrogens; you would pretty much necessarily have to experiment the other side effects associated with an increased estrogens to androgens ratio in order to see any sign of gynecomastia. I have yet to hear someone reporting any sexual side effect from RU58841. Yes, at first sight, there's apparently something to be worried of : people are typically using concentrations of RU58841 up to 50 times the recommended dosage of finasteride. Since RU58841 is considered as a "stronger antiandrogen", one would be tempted to say that, while all of the applied product won't be systemically absorbed, there will certainly be plenty enough to cause drastic side effects. However, shall I remember that RU58841's biological activity is completly different than finasteride's (ie. one inhibits the 5-alpha reductase enzyme and one is a receptor antagonist), thus this kind of comparison can't be made. This being said, RU58841 might somehow degrades/decay over time, thus the need to apply it everyday, and hence androgens will be able to bind to those receptors. Then again, RU58841 is nothing but a reversible antagonist of these receptors, androgens statistically still bind from time to time to all receptors.

To clarify: my "might as well get back on fin" comment was made with the understanding that fin gave me gynecomastia. Meaning I might as well deal with gynecomastia rather than go bald. It was meant as hyperbole.

And there is a difference between transplant-like results and the slightest sign of improvement, no? Even on minox at the 1.5 month mark I could see that vellus hair was improving. There was a noticeable difference. I'm not reading anything like that on the forums, not even phg.

I may indeed try RU after a few more BTT members report back; Clandestine said he experienced gyno on RU, that's the main hesitation. But if most others do not I'll give it a try.

[hellouser]

You should read my post, which is 3 posts before your own.



AFAIK, the conclusion forumers made out of BNP-32's study is that BNP-32 induces the growth of vellus hair which are expected to grow into terminal hair in a "normal" time frame (approx. a year). I've never started rubbing this chemical on my scalp thinking I'd have hair transplant like results in 2 weeks, it'd be completly foolish. There's no significant progress to report on my side, at this point.



I would be so much more worried about your finasteride. Gynecomastia is caused by the action of estrogens; you would pretty much necessarily have to experiment the other side effects associated with an increased estrogens to androgens ratio in order to see any sign of gynecomastia. I have yet to hear someone reporting any sexual side effect from RU58841. Yes, at first sight, there's apparently something to be worried of : people are typically using concentrations of RU58841 up to 50 times the recommended dosage of finasteride. Since RU58841 is considered as a "stronger antiandrogen", one would be tempted to say that, while all of the applied product won't be systemically absorbed, there will certainly be plenty enough to cause drastic side effects. However, shall I remember that RU58841's biological activity is completly different than finasteride's (ie. one inhibits the 5-alpha reductase enzyme and one is a receptor antagonist), thus this kind of comparison can't be made. This being said, RU58841 might somehow degrades/decay over time, thus the need to apply it everyday, and hence androgens will be able to bind to those receptors. Then again, RU58841 is nothing but a reversible antagonist of these receptors, androgens statistically still bind from time to time to all receptors.

Do you think RU could be the culprit behind a drop in libido?

[frankzukini]

Also how do the guys divide up the 10mg and apply it?

You should read my post, which is 3 posts before your own.

what a failure. first we hear "army of new vellus hairs" then it's no results and we have no idea why.

AFAIK, the conclusion forumers made out of BNP-32's study is that BNP-32 induces the growth of vellus hair which are expected to grow into terminal hair in a "normal" time frame (approx. a year). I've never started rubbing this chemical on my scalp thinking I'd have hair transplant like results in 2 weeks, it'd be completly foolish. There's no significant progress to report on my side, at this point.

I'm worried about gyno brother.

I would be so much more worried about your finasteride. Gynecomastia is caused by the action of estrogens; you would pretty much necessarily have to experiment the other side effects associated with an increased estrogens to androgens ratio in order to see any sign of gynecomastia. I have yet to hear someone reporting any sexual side effect from RU58841. Yes, at first sight, there's apparently something to be worried of : people are typically using concentrations of RU58841 up to 50 times the recommended dosage of finasteride. Since RU58841 is considered as a "stronger antiandrogen", one would be tempted to say that, while all of the applied product won't be systemically absorbed, there will certainly be plenty enough to cause drastic side effects. However, shall I remember that RU58841's biological activity is completly different than finasteride's (ie. one inhibits the 5-alpha reductase enzyme and one is a receptor antagonist), thus this kind of comparison can't be made. This being said, RU58841 might somehow degrades/decay over time, thus the need to apply it everyday, and hence androgens will be able to bind to those receptors. Then again, RU58841 is nothing but a reversible antagonist of these receptors, androgens statistically still bind from time to time to all receptors.

[Conpecia]

Try RU maybe con?

I'm worried about gyno brother. I am going to monitor lantern and hellouser for a couple months more. Seriously though equol looks promising and will be available soon.

[Conpecia]

Bro's if big things happen you will find out about them. Just go about your business as if this stuff doesn't exist, and then if it turns out to be a viable treatment it'll be all gravy dawg.

That's the thing we get conflicting reports man. Also if big things happen price goes up and availability goes down, I'm not trying to spend a G on BNP-32 if I can get it now for a tenth of that. But you're right it's def healthier to be off the forums

[Dan26]

Bro's if big things happen you will find out about them. Just go about your business as if this stuff doesn't exist, and then if it turns out to be a viable treatment it'll be all gravy dawg.

[clandestine]

what a failure. first we hear "army of new vellus hairs" then it's no results and we have no idea why. jesus christ i may as well just get back on fin and deal with the sides. sick of stressing about this and being letdown over and over.

on to s-equol...

Try RU maybe con?

[Conpecia]

what a failure. first we hear "army of new vellus hairs" then it's no results and we have no idea why. jesus christ i may as well just get back on fin and deal with the sides. sick of stressing about this and being letdown over and over.

on to s-equol...

[oppenheimer82]

nobody has seen results and to be honest, i really think the problem lies in the fact that persons got bnp-32 that is not 100 % legit. other people will tell you that the patent does not make sense at all. (no third party testing has been conducted).

[MrBlonde]

It's been over 21 days now. Any updates?

Also how do the guys divide up the 10mg and apply it? 10mg is 0.010000g right, or have I got my numbers wrong.

0.01g / 21 (days) = an amount impossible to measure with our digital scales or do the guys plan to use more than one order of 10mg BNP from Kane to last for a 21 day treatment?

[EDB]

^what he said.

I'm only on RU right now. Been curious what would be good to add. Won't do min due to the sides

[MrBlonde]

So you think RU with BNP would be a very good combo?