2013

[clandestine]

Yeaaah 2013 Hurry it the ***** up, science!

Desmond; You're posts are great, and always encouraging. Thanks for your presence and positivity exuded on the forums, mate.

[DepressedByHairLoss]

Thats a LOT of good stuff to look forward to. Regardless of the advancements with Aderans/Histogen being available options in the near future, I'm still saving up as many pennies as possible for a procedure with Dr. Gho. I figure; if I'm to go completely bald, I may as well go from NW3 to NW1 right now and enjoy whatever awesome years I have left while I'm still relatively young. Whatever happens later on, cure or no cure won't matter, not much can stop this bullshit.

Writing this however, I'm *furious* with how much red tape there is and the disgustingly slow progress there has been for hair loss sufferers. I really want to rip someones head off for making all of us suffer for this long. They can clone a sheep, cure blindness with stem cells, treat and cure people from cancer..... but they cant grow a strand of f*cking hair?

You raise some pretty legitimate concerns in that last paragraph. A lot of the red tape is really unnecessary; that's why a lot of these companies conduct their trials overseas. Also, I notice the hypocrisy when plenty of treatments are unnecessarily held up before they are available to the public, while others that cause great harm are not even regulated at all. I highly doubt that bimatoprost will cause any deadly side effects, yet that gets held up for years. Yet shoddy hair transplants have scarred, disfigured, and literally maimed countless numbers of people for 40 years, yet there is barely any regulation in the HT industry. The hypocrisy here is literally staggering.

You're right in your last sentence when you say: "They can clone a sheep, cure blindness with stem cells, treat and cure people from cancer..... but they cant grow a strand of f*cking hair?" It also boggles my mind to think that they can clone an entire organism but cannot grow a strand of hair. The lack of innovation in the hair restoration industry is staggering. But as I say, the main players in the industry are making ridiculous amounts of money with today's current methods so I doubt they would want any new methods to arise and thereby make their current methods obsolete.

[rdawg]

Also....

- Allergens Bim trials

- And maybe some news about a PGD2 treatment

PGd2 blocking + histogen + aderans might equal total regrowth. Maybe its PGD2 that prevents histogen from having amazing results in regards to dormant follicles. The guys in white coats need to get together and connect the dots.

I've thought of something like that, maybe with Fin or Aderans or PGD2 or even some/all 3 on top of histogen can cause it to be more powerful so that it works much better.

I.E picture histogen fighting against aggressive MPB so much that it only partially works, but have stuff like Fin that stabalizes the MPB, so that there isnt really a defense and histogen can work to it's fullest extent.

I dont know if that's possible, but it's an idea i'd think.

[neversaynever]

I've thought of something like that, maybe with Fin or Aderans or PGD2 or even some/all 3 on top of histogen can cause it to be more powerful so that it works much better.

I.E picture histogen fighting against aggressive MPB so much that it only partially works, but have stuff like Fin that stabalizes the MPB, so that there isnt really a defense and histogen can work to it's fullest extent.

I dont know if that's possible, but it's an idea i'd think.

I was thinking about the signals. The DP (and maybe some fat cells aswell) signal the stem cells around the follicle to start growing hair. The stem cells become progenitor cells, and we become hairy. DHT disrupts the signal between the DP cells and stem cells (BMPs heavily involved here). We could add new DP cells with fewer DHT receptors, but for some reason the signals are still not returning to normal (aderans, replicel with regrowth but minor). So these cell based treatments seem to be reviving recently dormant follicles or saving shrinking follicles (vellus to terminal).

Dr cots says there are still stem cells, but they are not doing their job. So whats blocking that signal? Theres so much involved, TGFs, BMPs, Wnt, an other cell type which i cant remember the name off, PGd2, pge2 etc etc etc. Histogen look to skip the cell talk and create the signal via HSC. Thus, they are converting alot of vellus hairs to terminal. But why not follicles which are no longer producing hair that extends past the skin?

Maybe its the PGD2 buildup....

follicles can recruit many new cells, or be stimulated by minox, or hsc, or whatever. But the PGD2 which literally surrounds the follicle might be preventing the induction of new cells and signals. Therefore, a pgd2 road block, along with aderans or histogen, might be the ticket. Maybe theres too much pgd2 around the follicle fighting histogens HSC, or any new cells from sending out signals.

Thats my laymens, probably ignorant, view of it. For now...

[hellouser]

Uh it would definitely work but I'm 100% sure the side effects you'd experience are the same as oral fin!

This study I just posted though has nothing to do with fin! They're talking about gene therapy with mRNA to reverse hair loss!

Wouldnt the side effects only occur if finasteride were to enter your bloodstream when taken topically? I dont see how side effects would happen otherwise. I've been taking RU58841 for about a year and have had no known side effects. Last few weeks my sex drive has been quite low though I can only blame that on a lot of stress and pressure from work, so no time to even think or be interested in sex... although at one point my libido did go through the roof. I don't see how topical finasteride would have the same side effects.

I suppose one could buy a large cheap supply of finasteride and mix it with Rogaine (or some other minoxidil formula). Take that once daily along with RU also once day and it could prove to be a pretty awesome trifecta.

[neversaynever]

Ive yet to read any study that looks at the effect of pgd2 on stem cell differentiation to progenitor cells. If anyone knows of a study, please post it here....

[neversaynever]

Wouldnt the side effects only occur if finasteride were to enter your bloodstream when taken topically? I dont see how side effects would happen otherwise. I've been taking RU58841 for about a year and have had no known side effects. Last few weeks my sex drive has been quite low though I can only blame that on a lot of stress and pressure from work, so no time to even think or be interested in sex... although at one point my libido did go through the roof. I don't see how topical finasteride would have the same side effects.

I suppose one could buy a large cheap supply of finasteride and mix it with Rogaine (or some other minoxidil formula). Take that once daily along with RU also once day and it could prove to be a pretty awesome trifecta.

I wish we could have minox and RU in one topical.

[HARIRI]

I wish we could have minox and RU in one topical.

Thats my wish for real. If you have any idea where I can get something like this then please tell me

I still have no idea how will I use the RU58841 along with Rogaine before bedtime???

[neversaynever]

Thats my wish for real. If you have any idea where I can get something like this then please tell me

I still have no idea how will I use the RU58841 along with Rogaine before bedtime???

Ive tried a few routines but now I just apply whenever I get the chance.

I refuse to keep minox on my scalp while i sleep (sometimes get a fast heart beat).

Today I applied minox at 6pm, washed off at 8.30pm, and put RU in. Ill wash out the RU in the next hour.

I cut my hair grade 0 short, so every drop is hitting my scalp. Minox is usually touch dry inside 2 hours, RU in KB solution is touch dry in an hour.

Maybe im wasting it all, and should leave it in for longer. But because of my short hair, i cant leave the house with a topical on my skin. It is clearly visible.

So to try and absorb a bit extra, i use a dermaroller. Also, when I do wash it out i use warm to hot water and massage my scalp to aid any last minute absorbtion (probably a waste of time). Anyway, thats how I do it. But its a routine dictated by my short hair.

There are days when i simply dont have time to use both. In that case, I just use RU.

I give my scalp a 'break' once a week (usually friday night). I do that because again of my short hair. Constant use of these topicals dries my skin a bit and it becomes visible to the whole world. I think thats the vehicles, rather than the actual drug.

If anyone got a suggestion on mixing minox and RU im all ears. Ive yet to read anything about it...

Specifically if RU and minox react to each other in the same solution, and also the proportions by which they can be mixed.

[hellouser]

Ive tried a few routines but now I just apply whenever I get the chance.

I refuse to keep minox on my scalp while i sleep (sometimes get a fast heart beat).

Today I applied minox at 6pm, washed off at 8.30pm, and put RU in. Ill wash out the RU in the next hour.

I cut my hair grade 0 short, so every drop is hitting my scalp. Minox is usually touch dry inside 2 hours, RU in KB solution is touch dry in an hour.

Maybe im wasting it all, and should leave it in for longer. But because of my short hair, i cant leave the house with a topical on my skin. It is clearly visible.

So to try and absorb a bit extra, i use a dermaroller. Also, when I do wash it out i use warm to hot water and massage my scalp to aid any last minute absorbtion (probably a waste of time). Anyway, thats how I do it. But its a routine dictated by my short hair.

Do you like the way you look with a completely shaved head? If I looked good, or better than with my messy hair I have, I dont think I'd mind keeping it shaved. Less maintenance and more vagina.... can't complain.

But, I understand your troubles with application. I usually apply Minox in the morning, just a little and apply RU at night. OR, I apply Minox right after work (5pm) and RU at night around midnight, which gives about 7 hours absorption for Minox and all night for RU.

[neversaynever]

Do you like the way you look with a completely shaved head? If I looked good, or better than with my messy hair I have, I dont think I'd mind keeping it shaved. Less maintenance and more vagina.... can't complain.

But, I understand your troubles with application. I usually apply Minox in the morning, just a little and apply RU at night. OR, I apply Minox right after work (5pm) and RU at night around midnight, which gives about 7 hours absorption for Minox and all night for RU.

It suits me more. Actually i used to cut grade 0.5 or 1. But since balding its been grade 0. Not had longer than grade 1 hair since I was 16!

Compared to you i wash it out very quickly, though I have the benifit of it all sitting on my scalp and not getting caught in the hair. Once its touch dry, would you say its ok to wash out?

Right now my scalp is completely dry after applying RU. Im about to wash it out. I sometimes wonder if im wasting minox and RU doing this...

[neversaynever]

Even at grade 0 theres a shadow on my head, and within a day hair is clearly visible. If i ever have to wet shave my head with a razor, ill be very annoyed. Willing to try anything to avoid that.

One thing about RU, im worried about having it on when my girlfriend stays round at mine. One night she touched my head right after i applied RU, and later that night she had stomach cramps. The pain went away within a few hours and maybe it had nothing to do with RU. But thats another reason i prefer to not keep it on at night.

Really need this pgd2 stuff to come through. Zero sides, and no hormone manipulation. But I am thankful for RU. Worked very quickly for me

[hellouser]

It suits me more. Actually i used to cut grade 0.5 or 1. But since balding its been grade 0. Not had longer than grade 1 hair since I was 16!

Compared to you i wash it out very quickly, though I have the benifit of it all sitting on my scalp and not getting caught in the hair. Once its touch dry, would you say its ok to wash out?

Right now my scalp is completely dry after applying RU. Im about to wash it out. I sometimes wonder if im wasting minox and RU doing this...

Lucky bastard. I've always get a mix of comments that I look like Rivers Cuomo from Weezer, the main guy from Linkin Park and sometimes Moby..... The way I see it, is if I'm already getting comparisons to looking like Moby WITH hair.... I can only imagine what would happen if I shaved it all off.

[Pate]

Even at grade 0 theres a shadow on my head, and within a day hair is clearly visible. If i ever have to wet shave my head with a razor, ill be very annoyed. Willing to try anything to avoid that.

One thing about RU, im worried about having it on when my girlfriend stays round at mine. One night she touched my head right after i applied RU, and later that night she had stomach cramps. The pain went away within a few hours and maybe it had nothing to do with RU. But thats another reason i prefer to not keep it on at night.

Really need this pgd2 stuff to come through. Zero sides, and no hormone manipulation. But I am thankful for RU. Worked very quickly for me

What effects did RU have for you? Much regrowth? I'm about to start and wondering what to expect.

[Pate]

Also....

- Allergens Bim trials

- And maybe some news about a PGD2 treatment

PGd2 blocking + histogen + aderans might equal total regrowth. Maybe its PGD2 that prevents histogen from having amazing results in regards to dormant follicles. The guys in white coats need to get together and connect the dots.

Also don't forget CB. Should hear something this year, if only for the acne formulation. And hopefully find out who this "major multinational specialty pharmaceutical company" is who bought the marketing rights for it. You don't fork out $25 million unless you're confident you're onto something.