Histogen at the ISHRS conference

[garethbale]

Party at my house in June. Everyones invited.

As long as it can prevent more hairloss or give decent regrowth that would be good. I still have most of my hair but need to fill my hairline in and I don't want to go for a HT.

If and when this does come to fruition I think we should all meet up and have a massive drinking session, the bender of all benders...London...New York...i don't mind

[hellouser]

They will definitely have something out in 2015!

What it's potentials are as a new therapy will be announced in June this year!

It's just a matter of waiting and remaining positive!

Party at my house in June. Everyones invited.

[Desmond84]

They will definitely have something out in 2015!

What it's potentials are as a new therapy will be announced in June this year!

It's just a matter of waiting and remaining positive!

[garethbale]

LOL really! yep 1984 it is

With regards to the stem cells, Dr Costralis (who is EPIC btw) did major studies on it for over 3 years and published his findings in 2010. He found that your stem cells are completely intact in balding areas! The signals to turn them on is lacking! So if they decide to go down the stem cell path there is most probably no improvement in hair density what so ever!

Really?

If Aderans were moving to stem cells that doesn't seem to make an awful lot of sense. I mean, if their results would be poor it would soon be pretty obvious that this was not a great treatment and I imagine people wouldn't pay for it.

I have read a bit on Adreans and one thing they don't seem to lack is money. Funding for lab work can't be a major problem for them.

On the one hand I want them to release a product that will give a real improvement, yet on the other I just want them to hurry up and release something!

[Desmond84]

Ahhhh ok...thanks mate

Are stem cells of lesser quality to DP cells then? Presumably they wouldn't yield as impressive a result.

I have read the Dr Nigam thread and cannot say I'm convinced at all by him, though I guess the more options available the better. I hope Aderans are pursuing the DP idea if this would make hair DHT immune, but I am getting quite impatient for a product to be launched. I first started reading about all these novel breakthroughs (HM etc) in 2008 and 5 years on, am still waiting. I might try to contact Aderans to ask what's happening.

No need to apologise for anything, you provide a lot of good info which I enjoy reading.

Btw is your username the year of your birth...if so you were born in the same year as me

LOL really! yep 1984 it is

With regards to the stem cells, Dr Costralis (who is EPIC btw) did major studies on it for over 3 years and published his findings in 2010. He found that your stem cells are completely intact in balding areas! The signals to turn them on is lacking! So if they decide to go down the stem cell path there is most probably no improvement in hair density what so ever!

[hellouser]

Ahhhh ok...thanks mate

Are stem cells of lesser quality to DP cells then? Presumably they wouldn't yield as impressive a result.

I have read the Dr Nigam thread and cannot say I'm convinced at all by him, though I guess the more options available the better. I hope Aderans are pursuing the DP idea if this would make hair DHT immune, but I am getting quite impatient for a product to be launched. I first started reading about all these novel breakthroughs (HM etc) in 2008 and 5 years on, am still waiting. I might try to contact Aderans to ask what's happening.

I'm curious about this too!

[garethbale]

Add me to the list of 1984 kids. George Orwell's book has also had an impact on my life too.... always taking everything with a grain of salt.

absolutely love that book...amazing!

[hellouser]

Btw is your username the year of your birth...if so you were born in the same year as me

Add me to the list of 1984 kids. George Orwell's book has also had an impact on my life too.... always taking everything with a grain of salt.

[garethbale]

Hey Gareth

What Aderans is said to be using is a type of cells called DP (Dermal Papillae)!

Now imagine a doorway where DHT floods into your hair and shrinks your follicles. This doorway is only found on DP cells on top of your scalp! That's right, the back of your head lacks this and therefore DHT has no impact on your donor area (hence the horse shoe pattern).

So what Aderans proposed to do back in 2002 was to grow these DP cells that are immune to DHT in the lab and then inject them into your miniaturised follicles.

This would practically make your hairs resistant to DHT and practically prevent you from having to take Propecia ever again.

Now unfortunately some how Dr. Nigam who's reputation is still on the line claimed last week he spoke to Dr Lauster and he informed him that Aderans gave up on the DP idea years ago and is only using stem cells!

This was such a SHOCK to us all that the forum kind of turned upside down (myself included). But after doing a bit more research the last few nights I think DP cells are still in Aderans and Nigam is just stirring us for some reason!

Again I'm really sorry for the breakdown yesterday! I'm just so sick of dealing with MPB just like all of you guys and hearing news like that really ripped me to shreds!

Ahhhh ok...thanks mate

Are stem cells of lesser quality to DP cells then? Presumably they wouldn't yield as impressive a result.

I have read the Dr Nigam thread and cannot say I'm convinced at all by him, though I guess the more options available the better. I hope Aderans are pursuing the DP idea if this would make hair DHT immune, but I am getting quite impatient for a product to be launched. I first started reading about all these novel breakthroughs (HM etc) in 2008 and 5 years on, am still waiting. I might try to contact Aderans to ask what's happening.

No need to apologise for anything, you provide a lot of good info which I enjoy reading.

Btw is your username the year of your birth...if so you were born in the same year as me

[Desmond84]

Hey Gareth

What Aderans is said to be using is a type of cells called DP (Dermal Papillae)!

Now imagine a doorway where DHT floods into your hair and shrinks your follicles. This doorway is only found on DP cells on top of your scalp! That's right, the back of your head lacks this and therefore DHT has no impact on your donor area (hence the horse shoe pattern).

So what Aderans proposed to do back in 2002 was to grow these DP cells that are immune to DHT in the lab and then inject them into your miniaturised follicles.

This would practically make your hairs resistant to DHT and practically prevent you from having to take Propecia ever again.

Now unfortunately some how Dr. Nigam who's reputation is still on the line claimed last week he spoke to Dr Lauster and he informed him that Aderans gave up on the DP idea years ago and is only using stem cells!

This was such a SHOCK to us all that the forum kind of turned upside down (myself included). But after doing a bit more research the last few nights I think DP cells are still in Aderans and Nigam is just stirring us for some reason!

Again I'm really sorry for the breakdown yesterday! I'm just so sick of dealing with MPB just like all of you guys and hearing news like that really ripped me to shreds!

[garethbale]

Yeah unfortunately Kiwi is right! Any novel approach to a new therapy takes around 10-15 years!

Aderans started their studies back in 2002. They are now 11 years into proof of concept and approval process! With at least 2 more years to go!

Histogen started back in 2005! So they are now just over 8 years into their approval process. They expect to release in Asia in 2015 and USA in 2017 which still falls within the 10-15 year bracket!

I personally believe we are so lucky that its 2013 right now NOT 2002! We are way closer than those poor souls waiting on it back then!

- Lets just hope Histogen & Aderans can really show what they claim by June this year!

Hi Desmond

I don't engage in a lot of activity on here but I do read a lot of your posts with interest. You seem to be quite knowledgeable on here so thanks for your input.

Can I ask why you seemed so negative on the Aderans thread yesterday? I don't really understand what's going on with that one...

[Desmond84]

15 years ? Really ?

If that's the case why are Histogen / Replicel / Aderans mentioning release dates in the next few years? I know they want to keep us interested but surely they would not give us these time frames if FDA approval took 15 years.

Yeah unfortunately Kiwi is right! Any novel approach to a new therapy takes around 10-15 years!

Aderans started their studies back in 2002. They are now 11 years into proof of concept and approval process! With at least 2 more years to go!

Histogen started back in 2005! So they are now just over 8 years into their approval process. They expect to release in Asia in 2015 and USA in 2017 which still falls within the 10-15 year bracket!

I personally believe we are so lucky that its 2013 right now NOT 2002! We are way closer than those poor souls waiting on it back then!

- Lets just hope Histogen & Aderans can really show what they claim by June this year!

[hellouser]

I'm laughing at your naïveté, I wish us mere plebs could speed it up but we can't. It's American beauroracy. Ill tell you one thing - if you guys make the mistake of electing a red neck Christian whos opposed to stem cell research we're all ****ed!!!

God bless Obama voters.

Oh yeah and for the record everything new takes about 15 years to go through FDA approval no matter what.

Completely false.

A quick look at wikipedia showed an average approval time for drugs of 7 years. Protests were done in the 80s/90s over HIV drugs to and some were given a pass only 2 years after.

Finasteride at 5mg was approved in 1992. At 1mg it was approved by 1997.

So, having said that... where did you come up with the 15 year long approval process?

More importantly:

WHY ARE YOU SO PASSIVE ON AN ISSUE THATS CLEARLY IMPORTANT TO YOU? <-- I really want an answer to that.

Its funny that some of you want a cure but will let the FDA steamroll over you and throw your arms in the air with defeat. 10 years have gone into Aderans research, I think the FDA is well stacked with enough data to prove its safety and efficacy. I'd expect this kind of passive behaviour and mentality from Canadians since they are major pussies when it comes to raising their voice against governing bodies, but I'm shocked to see this from Americans too.

[garethbale]

Oh yeah and for the record everything new takes about 15 years to go through FDA approval no matter what.

15 years ? Really ?

If that's the case why are Histogen / Replicel / Aderans mentioning release dates in the next few years? I know they want to keep us interested but surely they would not give us these time frames if FDA approval took 15 years.

[hellouser]

hey did u read my last post as to why we should push the FDA? theres a powerful group of HT docs called the HT mafia. and when they dont want to lose their profits to something like histogen, i'm sure theyll influence the FDA to "question" its safety and release.

And they are *nothing* compared to the collective group of everyone else in the balding community. After Phase III trials are over there is no reason for further delays, Phase I proved safety years ago.

Its your duty as a citizen to squash bullshit from the 'mafia' eventhough you shouldnt have to have this duty. (utopian outlook). HT docs will still have jobs, they'll just have to adjust their business and this needs to happen; out with the old, in with the new.

I would not accept any release past 2015 from Aderans should the FDA stall them. I'd raise absolute hell.