Histogen at the ISHRS conference

[rdawg]

I'm a 17 year old that was born with a huge widows peak, and now I've also got some temple recession going on. So basically what I have to do is hold onto my hair for roughly 2 and a half to 3 more years via something like RU and then I'll just get Histogen Injections and my hair will become DHT resistant? I know so far they can only claim 2 years of effectiveness because they only have 2 years of data, but it seems like histogen will be a permanent solution, judging by the way it works.

edit: and aren't aderans and histogen essentially the same thing but they're tackling it via different methods? so basically now its just a race to see who gets it done first.

From what I understand. Aderans originally wanted to cause growth, but could not do so.

Aderans however is effective in one thing, immunizing the hairfollicles from DHT. Think a guarenteed attack against MPB, unlike Fin which works in varying degrees for different people. However the catch is aderans will only work for 60% of people, due to genetics. So essentially they'll test to see if you respond before hand.

Ideally, if Histogen improves the solution further, Aderans and Histogen together would make any other product useless, and would guarentee no further loss, as well as moderate regrowth.Hopefully histogen brings us up a norwood or so. Either way they should be great products to at least tide us over for an even bigger product(stem cell product for example) that will give us FULL regrowth.

From what i've seen, and not to get too optimistic, Minxodil+Aderans+Histogen should bring you from say a NW4 to a NW2-2.5. an early NW2 or so should be able to get most if not all their hair back.

[re22]

Has Aderans been shown to stop hair loss? I don't really know anything about what they've done.

[Kiwi]

From what I understand. Aderans originally wanted to cause growth, but could not do so.

Aderans however is effective in one thing, immunizing the hairfollicles from DHT. Think a guarenteed attack against MPB, unlike Fin which works in varying degrees for different people. However the catch is aderans will only work for 60% of people, due to genetics. So essentially they'll test to see if you respond before hand.

I didnt know this - so essentially you're saying Aderans could release this right now and it'd immunise people from MPB.

While that doesnt help me so much right now it would have helped me when I first noticed my balding.

rdawg - my understanding was that Aderans are growing hair follicles for us in dishes and then transplanting those into our heads. Does that mean they have a second / separate product that does the immunising?

[rdawg]

I didnt know this - so essentially you're saying Aderans could release this right now and it'd immunise people from MPB.

While that doesnt help me so much right now it would have helped me when I first noticed my balding.

rdawg - my understanding was that Aderans are growing hair follicles for us in dishes and then transplanting those into our heads. Does that mean they have a second / separate product that does the immunising?

I remember reading about what you're talking about, I thoguht that was what aderans was doing.

Desmond can clarify it better, but from what I've read recently, and someone can correct me on this if wrong, they have something to do with making the dermal papilla(hair follicles essentially) immune to DHT attacks or whatever.

The catch is the 60% success rate, which cannot go higher due to genetics. So it'll be pretty unlucky if you are of the 40% that isnt possible.

The interesting part in regards to regrowth is what this can do in combination with OTHER products, can Histogen restore the damaged hair, then Aderans re-immunise it and histogen helps to regrow it? or maybe in combination with minoxidil, or even fin on top.

I have no idea, all I know is more options are coming, and it's AWESOME.

[Kiwi]

I remember reading about what you're talking about, I thoguht that was what aderans was doing.

Desmond can clarify it better, but from what I've read recently, and someone can correct me on this if wrong, they have something to do with making the dermal papilla(hair follicles essentially) immune to DHT attacks or whatever.

The catch is the 60% success rate, which cannot go higher due to genetics. So it'll be pretty unlucky if you are of the 40% that isnt possible.

The interesting part in regards to regrowth is what this can do in combination with OTHER products, can Histogen restore the damaged hair, then Aderans re-immunise it and histogen helps to regrow it? or maybe in combination with minoxidil, or even fin on top.

I have no idea, all I know is more options are coming, and it's AWESOME.

I just need to stay strong and positive until these options come. Its damn depressing I tell you. So close yet so far away.

Out of everything I've read / seen I tend to think RU is about all people like I have at the moment.

Does RU cause shedding?

[Dan26]

I remember reading about what you're talking about, I thoguht that was what aderans was doing.

Desmond can clarify it better, but from what I've read recently, and someone can correct me on this if wrong, they have something to do with making the dermal papilla(hair follicles essentially) immune to DHT attacks or whatever.

The catch is the 60% success rate, which cannot go higher due to genetics. So it'll be pretty unlucky if you are of the 40% that isnt possible.

The interesting part in regards to regrowth is what this can do in combination with OTHER products, can Histogen restore the damaged hair, then Aderans re-immunise it and histogen helps to regrow it? or maybe in combination with minoxidil, or even fin on top.

I have no idea, all I know is more options are coming, and it's AWESOME.

You could OD on DHT as long as there are sufficient levels of growth factors in the scalp it should not matter...

[Dan26]

I just need to stay strong and positive until these options come. Its damn depressing I tell you. So close yet so far away.

Out of everything I've read / seen I tend to think RU is about all people like I have at the moment.

Does RU cause shedding?

Seems like with MOST who have tried, RU does not cause shedding...I'm starting it soon, as well as CB...going to compare results. I believe they are both viable options especially for those choosing not to use finasteride...RU would be the somewhat 'proven' treatment, while CB is at least completely side effect free, but not proven due to difficulty in identifying the suitable vehicle.

[Kiwi]

Seems like with MOST who have tried, RU does not cause shedding...I'm starting it soon, as well as CB...going to compare results. I believe they are both viable options especially for those choosing not to use finasteride...RU would be the somewhat 'proven' treatment, while CB is at least completely side effect free, but not proven due to difficulty in identifying the suitable vehicle.

Are there any good CB posts / images?

[Dan26]

Are there any good CB posts / images?

I've seen one lol....The problem with CB is the vehicle...People used it in the same vehicles as for the acne cream...so penetration for the scalp is very low...in the trials they used iontophorisis (basically a needle-less form of injection) with good results and no sides...I am going to try it with a new vehicle, and eventually going to micro-inject it....It is a tricky molecule, very large and apparently has to maintain crystalline structure to be effective and most normal vehicles can't provide that for it

I'll keep ya posted broski

[FearTheLoss]

Bad Luck Brian...."gets permanent sides from propecia, massive shed from minox, no regrowth, he's part of the 40% that aderans doesn't work for, histogen fails and he doesn't have good donor density"

[Kiwi]

Bad Luck Brian...."gets permanent sides from propecia, massive shed from minox, no regrowth, he's part of the 40% that aderans doesn't work for, histogen fails and he doesn't have good donor density"

Huh? What you talking about?

[2020]

Aderans however is effective in one thing, immunizing the hairfollicles from DHT.

bullshit. Not going to happen. This is such a simplistic view on this that it's painful to read... your follicles were "immune" to DHT(which has been there since puberty) before you started balding, are you aware of that?

Think a guarenteed attack against MPB, unlike Fin which works in varying degrees for different people. However the catch is aderans will only work for 60% of people, due to genetics. So essentially they'll test to see if you respond before hand.

due to genetics? Which genes are those? not going to happen. Who would be their target market? Baldies willing to pay thousands of dollars for a 50:50 chance of looking exactly the same(maintaining)?

Aderans and Replicel are finished. Everything else is 10+ years away. Histogen is our only hope.

[Kiwi]

Baldies willing to pay thousands of dollars for a 50:50 chance of looking exactly the same(maintaining)?

Aderans and Replicel are finished. Everything else is 10+ years away. Histogen is our only hope.

I would be willing to pay thousands to maintain my hair and keep my dick in working order. Caus f*u*c*k Fin. So yes there is a target market. Me as well as anybody else with money will pay for that.

Second. I'm not sure Aderans are finished. I think like most businesses they will eventually launch with whatever it is that they have. Even if it is just as good as minox some people will want it because it doesnt have sides.

I pretty much agree about Histogen being our only real hope BUT I would like to say that I'm keeping an open mind about RU. Some people are posting good results... fingers crossed 2020!

[clarence]

Aderans and Replicel are finished. Everything else is 10+ years away. Histogen is our only hope.

Looking at the pictures Histogen has so far provided, and considering the amount of documentation (despite the remaining inconclusiveness) that has been done about the HST, I'm surprised you put more hope into the lab rats. Already finished with the HST, while others are busy investigating it?

[Desmond84]

bullshit. Not going to happen. This is such a simplistic view on this that it's painful to read... your follicles were "immune" to DHT(which has been there since puberty) before you started balding, are you aware of that?


Aderans and Replicel are finished. Everything else is 10+ years away. Histogen is our only hope.

Fact 1: The cure to hair loss does not have to be found. It is sitting on the back of your head.

Fact 2: DHT is by far the main culprit, hence why Finasteride is so powerful at halting hairloss.

Fact 3: Androgen receptors have only been found on TWO types of cells in the hair follicle: 1) Sebaceous glands 2) Dermal Papillae

Fact 4: Dermal Papillae play the most important role in controlling hair growth cycle and producing hair growth factors.

Fact 5: Dermal Papillae on the back of the head lack Androgen receptors whereas Dermal Papillae on the crown and temples express a large number of Androgen receptors.

Therefore, most plausible hypothesis would be:

"By transplanting Dermal Papillae that lack Androgen receptors, the remaining hairs will continue to grow indefinitely"

P.S. TWO points you didn't take into account:

a) DHT levels prior to puberty are miniscule to non-existent.

b) It is called Male PATTERN Baldness for a reason. Hair loss occurs in a pattern rather than all at once because Androgen receptors get expressed in high numbers in specific areas at a time (i.e. in the temples/crown) and then vertex, etc. Your hair follicles didn't always have so many Androgen receptors. At some point in your life specific genes switch on that tells your hair to start making more Androgen receptors. That's why some ppl bald in their 20's some in their 50's!

Aderans is definitely on the right track and ahead of everyone else in terms of releasing their product first!

Anyhow we'll know by Early May if Aderans is definitely going into Phase 3 or not...so let's be optimistic rather than sitting back and waiting for the world to end for all balding men and women!

The science is on Aderans' side...let's be positive