Histogen show "cosmetic" results oct 2012 update

[UK_]

All we need is something that is capable of growing hair on a slick bald scalp - once it's developed and released you wont even need to worry about being a NW2 or 3.. because even if you wait until you're a NW7 you'll still have the OPTION of treating the hair loss.

Finasteride and Minox can arrest the hair loss in the majority of its users, but for people who have been suffering for years - 'arresting' the hair loss would be useless.

What I would like to see is some kind of cell therapy combined with traditional hair transplants, so you pay per graft and an extra circa £3,000 for the cell therapy that guarantees you better density.

[Dan26]

Two things I can say to you guys with confidence.

1) Histogen's formula works very well. It is not a 'cure', but it beats the hell out of anything currently available, and anything else that will be available in the near future (CB, OC etc,.)

2) It wont be cheap.

You don't have to take my word for it, as both are true and will be proven to you in a matter of time.

[Smiley]

This is the BIG point:



And you boys need to be realistic, there WILL be no cure. Just an improved treatment using stemcells, overtime as the treatment is perfected than a cure will be created.

Stemcell research is in its infancy.

Yes I agree. It's slightly disappointing that we probably won't see a true 'cure' withing the next 10 years. But at the same time I'm excited to see these new treatments and what they may become.

A "cure" would be great. But, honestly, i would be happy if they came out with something that could arrest the balding process and provide some mild regrowth - maybe upgrade you a norwood level. That, plus what we have available with hair transplant technology and Gho's HST would be enough to save most from having to suffer the fate of the everlasting horsehoe.

For guys NW4 or lower, that would practically be a cure. Use the treatment to get to a NW3 and stop further loss. Then you could go to Rahal/Feller/H&W or whomever and feel perfectly ok saying lower that mother-f'er and make it straight and dense.

I don't think this type of approach is out of reach, and could be available within next 5 years from Histogen. Maybe Aderans is having luck - they certainly are putting a lot of money into it and that they're moving to phase III is very, very encouraging.

This post is right on point! cheers!

[Smiley]

2) It wont be cheap.

.

If it works, price won't be an issue for me. I'm not rich but I'll find the money!

[UK_]

Histogen have stated it will be available to a mass market - so dont worry about the price.

[gutted]

A "cure" would be great. But, honestly, i would be happy if they came out with something that could arrest the balding process and provide some mild regrowth - maybe upgrade you a norwood level. That, plus what we have available with hair transplant technology and Gho's HST would be enough to save most from having to suffer the fate of the everlasting horsehoe.

For guys NW4 or lower, that would practically be a cure. Use the treatment to get to a NW3 and stop further loss. Then you could go to Rahal/Feller/H&W or whomever and feel perfectly ok saying lower that mother-f'er and make it straight and dense.

I don't think this type of approach is out of reach, and could be available within next 5 years from Histogen. Maybe Aderans is having luck - they certainly are putting a lot of money into it and that they're moving to phase III is very, very encouraging.

there will be NO cure for male pattern baldness. people who think this will happen are living in a dream world.

trying to cure mpb through genetic therapy will almost be a death sentance. Since the genes that cause baldness are the genes that code for infllamatory enzymes/protiens and tumor suppressor genes, As you can imagine removing these genes will kill you.

At most we would have a super treatment, enough to make us forget about the fact we are suffering from mpb along with the identification of why mpb occurs.

For the nw7s, there would be a treatment that would reverse fibrosis at a decent/acceptable time length, so hairs can grow out from deep within the scalp.

[Dan26]

Histogen have stated it will be available to a mass market - so dont worry about the price.

Just because it will be available to a mass mo market does not mean it will be cheap. Remember it is a cosmetic treatment. I don't want to be negative man, but I don't see it as being affordable for everyone. Obviously depends on the extent of ones baldness, but it will be thousands a year.

[The Alchemist]

Just because it will be available to a mass mo market does not mean it will be cheap. Remember it is a cosmetic treatment. I don't want to be negative man, but I don't see it as being affordable for everyone. Obviously depends on the extent of ones baldness, but it will be thousands a year.

They need to keep this within easy reach of most household incomes. If they over price it, they'll end up excluding a huge chunk of the total market. Sure guys on this forum will pay any price. But that's due to the desperation that brought them to this forum in the first place. Most guys don't like their baldness but aren't as horrified by it as the people who come to forums for help. So they won't be willing to pay an exorbitant amount of money. Further, most people have bills to pay, mouths to feed and college to save for; which take precedence over hair, by a long shot. If Histogen is to be successful, they will need to mindful of that.

Plus, histogen has already demonstrated continued growth out past one year...so the frequency of treatment will probably be longer then every year.

My prediction is that this will be 1500-2500 treatment which will need to be repeated every 2-3yrs or so. If it's more then 5000/treatment it's not going to be a big seller.

[Arashi]

Stemcell research is in its infancy.

Not exactly. Huge breakthroughs were made in the last few years and we now have people walking around with generated organs made of stem cells (bladder, windpipe, but more complex organs are being developed as we speak). Did you maybe miss the news about Osiris, who got the very first FDA approved stem cell therapy this year ? And did you forget about that Japanese professor who generated hair and transplanted it onto a mouse last April ? http://www.sciencedaily.com/releases...0418095011.htm
Sure, we're still years away from this method being applicable to humans, but saying stem cell research is in its infancy really doesn't do justice to the huge breakthroughs we've seen in the last few decades and especially the last 1-2 years.

[Desmond84]

Stay positive guys

You know guys, I've been looking at old posts on TBT and other forums between 2002 and 2010 and something really stood out to me.

All ppl talked about was:
- Some study by some random doctor in the 80s that showed emu oil awakens hair follicles!!!
- Revivogen - a natural cure!!!!
- Saw palmetto
- RU
- Zinc
- Copper peptides
- Wound roller!!!!
- Aminexil by Loreal
- the list goes on and on

and ppl were trying all this sh**! everyone was so positive about it and trying to document their progress. Obviously, we now know with hines sight that most either don't work or if they work we don't know if they're safe (RU, CB, copper, etc)!!!

Ppl had no idea about how much regrowth it might give them or would it even halt their hair loss.

Now, today we have a product thats coming to the market that would hopefully give ppl back some of their hair and they're doing all the safety and efficacy testing for us. So we can use these with a peace of mind.

But instead of appreciating it, all we're doing is bagging it out and down playing it. Guys, clinical trials are there for a reason. They are to prove safety and efficacy. Every single bit of data that gets released has to get peer-reviewed and FDA-reviewed by experts in the field of hair loss, dermatology, biotechnology, etc before their results can get published and their products approved!

So plz STAY POSITIVE.

Gail, Washenik, Ziering and many more are all here to make life better for all of us. Don't downplay results and numbers and make everyone depressed! We have enough to worry about!

Cheers to all u awesome ppl

[Kirby_]

Desmond84, I think you've identified why old-timers are so negative! They've seen so many bloody worthless things come and go. I did similar to you a while back and trawled back through hairloss forum posts to 2002, it's depressing. Still, I hope that we see light at the end of the tunnel soon, whther through expensive 'super treatments' or the Prostaglandin model, hopefully both.

[Desmond84]

Desmond84, I think you've identified why old-timers are so negative! They've seen so many bloody worthless things come and go. I did similar to you a while back and trawled back through hairloss forum posts to 2002, it's depressing. Still, I hope that we see light at the end of the tunnel soon, whther through expensive 'super treatments' or the Prostaglandin model, hopefully both.

You know Kirby, right now we have TWO therapies in Phase 2 trials (Histogen & Aderans) BOTH showing very positive results, with solid financial backing and a great pool of cutting edge scientists.

On top of that we have a product called Replicel in Phase I, which showed to be even more effective than Aderans in pre-clinical trials. Now, they're lagging behind, they wont release a 12 month update, their 6 month update wasn't that great. I know all that, trust me! But, they're still moving forward, and who knows what they're seeing right now as we speak at the 12 month follow-up.

We have a great future ahead of us that looks very promising.

I mean I look back at 90's and all Merck scientists could think of was: "well this race of men in Dominican republic can't produce DHT and don't go bald! So, we should just knock this major hormone out of men to stop baldness" - I mean seriously...

Guys, we are so close to the light! be happy! go to parties! find a gf, live a happy life...science will bring you the answers you've been seeking all this time patience is a virtue.

And to all the old timers, I respect you all guys and your wise words should always be heard. But maybe this time, science has found the answer and it doesnt involve a natrual alternative!

- Peace

[gmonasco]

I mean I look back at 90's and all Merck scientists could think of was: "well this race of men in Dominican republic can't produce DHT and don't go bald! So, we should just knock this major hormone out of men to stop baldness" - I mean seriously...

Errr, no. Finasteride was developed by Merck as a treatment for enlarged prostates, not hair loss. That it also produced slight hair regrowth in some men with MPB was an unexpected and unintended side effect.

[Desmond84]

Errr, no. Finasteride was developed by Merck as a treatment for enlarged prostates, not hair loss. That it also produced slight hair regrowth in some men with MPB was an unexpected and unintended side effect.

Hey GMONASCO,

here's a bit of history I dug out of my Pharmacology book:

"In 1974, Julianne Imperato-McGinley of Cornell Medical College in New York attended a conference on birth defects. She reported on a group of hermaphroditic children in the Caribbean who appeared sexually ambiguous at birth, and were initially raised as girls, but then grew external male genitalia and other masculine characteristic post-onset of puberty. Her research group found that these children shared a genetic mutation, causing deficiency of the 5α-reductase enzyme and male hormone dihydrotestosterone (DHT), which was found to have been the aetiology behind abnormalities in male sexual development. Upon maturation, these individuals were observed to have smaller prostates which were underdeveloped, and were also observed to lack incidence of male pattern baldness.

In 1975, copies of Imperato-McGinley's presentation were seen by P. Roy Vagelos, who was then serving as Merck's basic-research chief. He was intrigued by the notion that decreased levels of DHT led to the development of smaller prostates who lacked androgenetic alopecia. This led to development of the first Type 5 alpha-reductase inhibitor known as Finasteride".

- True story

[Conpecia]

Pwned

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