Cetirizine

[justeone]

is this treatment working at all?

[thechamp]

How are people getting results with cet ??

[KO1]

^Fascinating, I take that back then.

[walrus]

I don't think CET is a PGD2 blocker.

http://www.ncbi.nlm.nih.gov/pubmed/2469708

Histamine release was not altered by cetirizine treatment, but prostaglandin D2 (PGD2) production, which peaked at 3 to 5 hours, was clearly reduced by cetirizine treatment, being lower at all time points during the reaction

and http://www.ncbi.nlm.nih.gov/pubmed/7741033

Cetirizine (0.1-10 micrograms/ml) enhanced PGE2 release by resting human monocytes

[Pentarou]

The lack of success with CRTH2 blockers has been a real downer, IMO. There must be a huge vital piece in the puzzle missing. Or Cotsatelis was trolling us.

[KO1]

What has been disappointing to me is the lack of good results reported by Ramatroban users. As you know, it is a CRTH2 antagonist, so it should be better than Indo/Cromo...but people are reporting "stops shedding" on Indo but nothing on Rambo...

[KO1]

I don't think CET is a PGD2 blocker.

[thechamp]

So we just bang a few Zyrtec tablets in to minoxdil?, also does everyone get a shed on cet?

[Conpecia]

I'm bumping this because someone brought up PGD2 blockers (which CET is) on ************ forums and four or five guys immediately responded that CET has stopped their hairloss. These guys have been on CET for something like 8-9 months by now, I remember when they first started way back in October/November of last year. The PGD2 theory seems more and more legitimate. Also, for those worried about indo/chromo sides, CET may be a safer alternative. And it's MUCH cheaper.

The thread:

http://www.****************/interact...-pdg2-blockers

[eqvist]

It would be interesting if we had people on fin and minox adding this!

[Conpecia]

Thanks. That's exactly what I will do as I already have everything.

Me too. But let me caution you: one guy said he burned a whole NW off his hairline using Cet that didn't grow back (not sure if he was using the right vehicle, nor do I think he stayed with it long enough to recover what he shed). But seeing as how you're on some other stuff, I'd wait until we get some more positive reports before adding it, honestly. One or two dudes claiming regrowth is great news, but it's by no means conclusive. We need like 20 people with pics over a year long period. I'd stick with your current regimen until we get more good news. Just lookin out for you man.

[Campbell22]

Vehicle is just Cet and water. Really simple. Anyone who's on Minox should consider adding it if the good news keeps coming.

Thanks. That's exactly what I will do as I already have everything.

[Conpecia]

Sorry guys, was up late last night and just wanted to report really quick. Here is the link:

http://www.****************/interact...opecia)/page79

Casperz has been on for 6 months and is obviously regrowing his crown area. Hasn't lost hair at all since his initial shed in the first month. That's the most important point to me, as minox alone would not be slowing down his loss.

Kamikaze has been on for 4 months and looks like he's regrowing a bit but there aren't before pics so take it with a grain of salt.

Chromeo is also saying he was on Minox for a while and didn't see anything, now that he's added Cet there are results. Unfortunately he has no before or after pics but I don't think there's any incentive for him to just lie about it; not like these are guys at some snake oil company who can profit off of selling Cetirizine, which is very cheap and widely available. Vehicle is just Cet and water. Really simple. Anyone who's on Minox should consider adding it if the good news keeps coming.

[Campbell22]

I jumped on the band wagon with this a few weeks ago and bought my local pharmacy out of the antihistamine but was only using it orally.

I know most people are using it topically and I know there probably isn't any reliable evidence yet to decide which route is better, if any.

But if the general consensus is that you have to do a quick extration of the pills and then use a vehicle then I will but at the moment I'm either just taking them orally or if Im more honest, lately not at all as Im quite happy with minox/capil/duta.

I did even go the MSM Vit C route and have massive stocks of both of them but am thinking it is probably best to take an additive approach as I had great results with fin just couldnt handle the sides and so far so good with Duta just obviously no regrowth as its only just been started.

If certirizine does prove successful then that would be great as in my head there is definitely an inflammatory involvement in MPB as well as many other possible factors. the obvious being DHT of course.

[clandestine]

Links? Pics?

Seconded. Claims need proof..