Tsuji-lab (Team Tokyo)

[Desmond84]

desmond give me your email to send you the paper.I have access to almost every database so in the future don't hesitate to ask me.

mm05035 thank u so much brother

I actually found it on Tsuji-lab website! Very fascinating stuff...

I'll be posting about it this weekend

[Desmond84]

Just to give you guys a quick update:

Over the past week, I have read ALL scientific literature published by Tsuji Lab relating to Hair & Tooth regeneration.

Tsuji lab has most definitely found the cure! They have a 3D scaffold to grow the stem cells and just recently we have found the means to expand these stem cells in culture! (i.e. multiplying hair follicles)

However, the Tsuji team found that even though implanting hair germs worked in terms of forming hair follicles, it yielded hair follicles with different sizes and orientation which were aesthetically unacceptable!

So, they designed a second study, which involved implanting the hair germs in the "subrenal capsule" of mice (an area of kidney) and allowed the germs to grow to an acceptable maturity. They then extracted these mature hair follicles and implanted it on the back of the mouse neck using the FUT method!

Pretty much, what Tsuji is working on now is finding a method to grow the hair germs to maturity in a human to allow for FUT implantation!

Obviously, we can't grow it on our kidneys, so they're working on some vascularised tissue model to grow these seeds on!

I think that's everything I could gather! Don't hesitate to ask anything guys I'll try my best to answer it...

[Henkeh91]

Just to give you guys a quick update:

Over the past week, I have read ALL scientific literature published by Tsuji Lab relating to Hair & Tooth regeneration.

Tsuji lab has most definitely found the cure! They have a 3D scaffold to grow the stem cells and just recently we have found the means to expand these stem cells in culture! (i.e. multiplying hair follicles)

However, the Tsuji team found that even though implanting hair germs worked in terms of forming hair follicles, it yielded hair follicles with different sizes and orientation which were aesthetically unacceptable!

So, they designed a second study, which involved implanting the hair germs in the "subrenal capsule" of mice (an area of kidney) and allowed the germs to grow to an acceptable maturity. They then extracted these mature hair follicles and implanted it on the back of the mouse neck using the FUT method!

Pretty much, what Tsuji is working on now is finding a method to grow the hair germs to maturity in a human to allow for FUT implantation!

Obviously, we can't grow it on our kidneys, so they're working on some vascularised tissue model to grow these seeds on!

I think that's everything I could gather! Don't hesitate to ask anything guys I'll try my best to answer it...

Looks really promising. When do you think this will be available (if it goes well)?

[Desmond84]

Looks really promising. When do you think this will be available (if it goes well)?

Henkeh,

This is the real cure that everyone is talking about brother

But we have to be patient! Realistically speaking it won't be available worldwide at least till 2020...

What's important is that we have a working solution. That is the first step to happiness

[clarence]

Tsuji Labs on the other hand is actively trying to regenerate hair follicles for transplantation! If you read their paper in detail, they are literally creating "hair germs"; hair germs are formed in the embryo and turn into hair follicles when you are born! They implant 20 of these in a 1cm2 area (which is possible with our current technology and was done in their previous study) and that would give you over 100-120 hairs/cm2!

That is far more than a cure! You literally get the hair density that you had when you were 12!

I'm just curious how they are going to get anywhere near this density, if they are using the FUT method, with its limitations and risk of necrosis whatnot. I'm sorry, if is this is a didi question.

However, the Tsuji team found that even though implanting hair germs worked in terms of forming hair follicles, it yielded hair follicles with different sizes and orientation which were aesthetically unacceptable!

So, they designed a second study, which involved implanting the hair germs in the "subrenal capsule" of mice (an area of kidney) and allowed the germs to grow to an acceptable maturity. They then extracted these mature hair follicles and implanted it on the back of the mouse neck using the FUT method!

Pretty much, what Tsuji is working on now is finding a method to grow the hair germs to maturity in a human to allow for FUT implantation!

[Desmond84]

I'm just curious how they are going to get anywhere near this density, if they are using the FUT method, with its limitations and risk of necrosis whatnot. I'm sorry, if is this is a didi question.

You know what Clarence, I read all 5 articles Tsuji team has published and non of them mention anything about the hair density they achieved!

I'm not sure where these articles had found these claims!

On a side note though, I'm not very familiar with hair transplants. What kind of hair density can you achieve these days with a densely packed FUT?

[Henkeh91]

Henkeh,

This is the real cure that everyone is talking about brother

But we have to be patient! Realistically speaking it won't be available worldwide at least till 2020...

What's important is that we have a working solution. That is the first step to happiness

Alright, yea.. it feels hopefull when we get these kind of news although it's couple of years away.

I'll probably be slick bald NW6 by then so I hope it won't cost a fortune.

[Desmond84]

LOL they can probably fix up a NW6 in just one day

On a serious note though, 7 years is a longgg time! U should look into some kind of preventative measure if u can

[Henkeh91]

LOL they can probably fix up a NW6 in just one day

On a serious note though, 7 years is a longgg time! U should look into some kind of preventative measure if u can

I'm on minox, keto, fin, msm, vitamines, omega 3, revita.Started with fin for about a month ago though. We'll see how it works out (got pretty aggressive MPB in my family).

[Desmond84]

Henkeh if u keep up this regimen, I can promise you, you'll be hanging on to 90% of your hair till 2020!

Aggressive hairloss has nothing to do with efficacy of fin! They found a genetic mutation in 10% of population that affects responsiveness to Finasteride! You'll know soon enough

If by the sixth month you notice stabilisation and slight thickening then you're gonna be fine for a long time to come

[Henkeh91]

Henkeh if u keep up this regimen, I can promise you, you'll be hanging on to 90% of the hair you have today by 2020!

Aggressive hairloss has nothing to do with efficacy of fin! They found a genetic mutation in 10% of population that affects responsiveness to Finasteride! You'll know soon enough

If by the sixth month you notice stabilisation and slight thickening then you're gonna be fine for a long time to come

Wow thanks Desmond! Im glad that you are on this forum. Spreading hope and happines!

[hellouser]

I'm on minox, keto, fin, msm, vitamines, omega 3, revita.Started with fin for about a month ago though. We'll see how it works out (got pretty aggressive MPB in my family).

Add a little RU and you'll BALLIN'

[Thinning87]

Henkeh,

This is the real cure that everyone is talking about brother

But we have to be patient! Realistically speaking it won't be available worldwide at least till 2020...

What's important is that we have a working solution. That is the first step to happiness

2020 to me sounds like a very acceptable point in time to have a cure - I can shave for seven years - but I'm afraid this stuff would take longer.

[The Alchemist]

2020 to me sounds like a very acceptable point in time to have a cure - I can shave for seven years - but I'm afraid this stuff would take longer.

Great news is that this is probably the cure. Bad news is...

If these guys are still in the basic research phase, there is no way this will be available anywhere near 2020. If they started clinical trials tomorrow, then I *might* say 2020 is a realistic timeframe. But, they are a long way from clinical trials. Give them another 3-5 years (and it could be much longer than that) to figure it out, apply for clinical trials, recruit patients and then go through 3 or more phases, get approval, partnerships and then commercialize.... you're looking at 15-20 or more years.

[Thinning87]

Indeed....