Neogenic by L’Oréal

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  • new bubble
    Member
    • Aug 2012
    • 98

    Originally posted by Dazza
    Which makes it seem that loreals statement saying this is just one of there upcoming hairloss products and the rescent announcement from the loreal funded DrC. Maybe there thinking of releasing a pg blocker and using this product as the booster.
    Dazza: You've hit the nail on the head. Once you connect all the dots up together the picture is clear. Why this the the reason DR.C is going commercial.
    Bio techs firms will report all ther findings in the next 3 months. It will be HUGE!!!

    Connect everything thing up. 1. Amount of research in the last 10 years.
    2.The scientific research breakthrough. 3.Real Financial investment.
    4. Amount of Bio's trying to find cure-results vary but positve in general.
    5.Real race to market suggest they know something we don't. 6.Most will report phase2 this year. 7.Allergan suggesting good news in October. L'oreal with there stuff and other points. I'm more interested in what Rogain will due, bet they bring something out early next year based on DR C reasearch. and on and on and on In my opinion

    Comment

    • gutted
      Senior Member
      • Jan 2011
      • 1397

      Originally posted by new bubble
      .

      precisely!! this is what Dr C. is supposed to have achieved. He is addressing the underline issue once that is done and the foundations layed, growing hair will be much easier to do than presently achieved by minox an Fin. Well thats the logic. Now If the drugs for PGD2 are being currently used for asthma wonder if those users have hair problems??
      Cyclooxygenase (COX)-1 and -2 catalyze the key reaction in prostaglandin biosynthesis. Whereas COX-1 is found in most tissues, COX-2, with a few exceptions, is not expressed in normal tissues but becomes transiently induced in the course of inflammatory reactions. In many neoplastic epithelia, COX-2 …


      you dont need to address dht directly, dht's role in the body is to cycle the hair and initiate telogen (hair shedding)

      mpb occurs when dht is in the excess and means more hairs are cycling away into telogen (and eventually staying there) and cox2 is over inititated via dht resulting in excess pgd2 protien.

      normalising cox2 will allow you to enjoy decent results.

      i forgot to add overexpression of cox2 in the skin results in a high amount of collagen deposition which is where the perifollicular fibrosis comes in, in late stage baldness.
      Our study demonstrated that VEGF, VEGF-R3 and COX-2 expression in psoriatic and nonlesional skin is significantly high in epidermis and dermis. Although there was significant concordance between VEGF and VEGF-R3 expressions in psoriatic lesions, there seems to be no concordance between the others.

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      • gutted
        Senior Member
        • Jan 2011
        • 1397

        Originally posted by new bubble
        Dazza: You've hit the nail on the head. Once you connect all the dots up together the picture is clear. Why this the the reason DR.C is going commercial.
        Bio techs firms will report all ther findings in the next 3 months. It will be HUGE!!!

        Connect everything thing up. 1. Amount of research in the last 10 years.
        2.The scientific research breakthrough. 3.Real Financial investment.
        4. Amount of Bio's trying to find cure-results vary but positve in general.
        5.Real race to market suggest they know something we don't. 6.Most will report phase2 this year. 7.Allergan suggesting good news in October. L'oreal with there stuff and other points. I'm more interested in what Rogain will due, bet they bring something out early next year based on DR C reasearch. and on and on and on In my opinion
        dr c for the past 2 years has given us updates 2 years in a row now, hopefully the third one, next year will be very very good.

        Comment

        • new bubble
          Member
          • Aug 2012
          • 98

          Originally posted by gutted
          dr c for the past 2 years has given us updates 2 years in a row now, hopefully the third one, next year will be very very good.
          l'OREAL obviously has the papers on the research Dr C HAD CONCLUDED AND HIS BREAKTHROUGH, his problem is he had to convince driug firms to invest and make the product whereas L'oreal is extremly well funded hence why they are coming to market first with there offering then we will see the pg2 blockers sooner than DrC can bring it. Greed will win despite the credit being Dr C's

          Comment

          • gutted
            Senior Member
            • Jan 2011
            • 1397

            Originally posted by new bubble
            l'OREAL obviously has the papers on the research Dr C HAD CONCLUDED AND HIS BREAKTHROUGH, his problem is he had to convince driug firms to invest and make the product whereas L'oreal is extremly well funded hence why they are coming to market first with there offering then we will see the pg2 blockers sooner than DrC can bring it. Greed will win despite the credit being Dr C's
            lets hope this loreal treatment works out.

            but i fear its going to be discredited for the reason i stated above...people who dont have thier hair loss under control are likeley to see 0 to little results and bring in some emotional bias and discredit the treatment.

            Comment

            • new bubble
              Member
              • Aug 2012
              • 98

              Originally posted by gutted
              lets hope this loreal treatment works out.

              but i fear its going to be discredited for the reason i stated above...people who dont have thier hair loss under control are likeley to see 0 to little results and bring in some emotional bias and discredit the treatment.
              or l'oreal know this and are keeping quiet, may even push it back in the eleventh hour until they can address the underline issue

              Comment

              • gutted
                Senior Member
                • Jan 2011
                • 1397

                Originally posted by new bubble
                or l'oreal know this and are keeping quiet, may even push it back in the eleventh hour until they can address the underline issue
                who knows..

                you could argue histogens treatment does not address dht/cox2/pgd2, yet it STILL grows hair.

                all im saying is results will not be astonishing for those that dont have thier hair loss under control.

                Comment

                • new bubble
                  Member
                  • Aug 2012
                  • 98

                  Originally posted by gutted
                  who knows..

                  you could argue histogens treatment does not address dht/cox2/pgd2, yet it STILL grows hair.

                  all im saying is results will not be astonishing for those that dont have thier hair loss under control.
                  By that statement about histogen being able to grow hair without addressing the dht and so on , implies theres a more profound reason to baldness thats not been talked about. Get your scalp condition to pre mpb level and you have hair in time

                  Comment

                  • Dazza
                    Senior Member
                    • Jun 2012
                    • 264

                    Originally posted by new bubble
                    By that statement about histogen being able to grow hair without addressing the dht and so on , implies theres a more profound reason to baldness thats not been talked about. Get your scalp condition to pre mpb level and you have hair in time
                    Or they are just injecting proteins/magic dust who knows that activate all your dormant DHT follicles, making The hair only last one phase. Hence you need "top ups"

                    Tho that's just a guess / speculation. I don't know

                    They might have a active ingredient that Does infact help the surrounding environment, hopefully more details in oct

                    **Typing on a iPad sucks. I had to edit this just to make sense..**
                    Last edited by Dazza; 08-25-2012, 09:34 AM. Reason: iPad is wank

                    Comment

                    • neversaynever
                      Senior Member
                      • Dec 2011
                      • 640

                      Originally posted by gutted
                      http://www.ncbi.nlm.nih.gov/pubmed/14632179

                      you dont need to address dht directly, dht's role in the body is to cycle the hair and initiate telogen (hair shedding)

                      mpb occurs when dht is in the excess and means more hairs are cycling away into telogen (and eventually staying there) and cox2 is over inititated via dht resulting in excess pgd2 protien.

                      normalising cox2 will allow you to enjoy decent results.

                      i forgot to add overexpression of cox2 in the skin results in a high amount of collagen deposition which is where the perifollicular fibrosis comes in, in late stage baldness.
                      http://www.ncbi.nlm.nih.gov/pubmed/18225391
                      When follicles in a non mpb scalp cycle, the hairs shed. But then why does mpb follicles shed and grow back thinner? Thin hairs occur when there are fewer active stem cells, so whats the connection? Or are the hairs simply not getting enough nutrients because of inflammation?

                      Comment

                      • gutted
                        Senior Member
                        • Jan 2011
                        • 1397

                        Originally posted by neversaynever
                        When follicles in a non mpb scalp cycle, the hairs shed. But then why does mpb follicles shed and grow back thinner?
                        it sheds and grows back thinner because of over expression of cox 2 during the regenerative stage that prevents full regeneration, instead half of it is regenerated.


                        Originally posted by neversaynever
                        Thin hairs occur when there are fewer active stem cells, so whats the connection? Or are the hairs simply not getting enough nutrients because of inflammation?
                        as above - the over expression of cox2->pgd2 acts as an inhibtro for full regeneration.

                        Comment

                        • Batman
                          Junior Member
                          • Aug 2012
                          • 6

                          hello everyone is there anyone who knows where you will be able to purchase this product in the US when it releases? and does this product look promising for a thinning NW3? any response would be appreciated thank you

                          Comment

                          • youngin
                            Senior Member
                            • Nov 2010
                            • 338

                            Originally posted by gutted
                            it sheds and grows back thinner because of over expression of cox 2 during the regenerative stage that prevents full regeneration, instead half of it is regenerated.
                            as above - the over expression of cox2->pgd2 acts as an inhibtro for full regeneration.
                            How do you know its an over expression? Maybe its years of pdg2 build up from being stuck in the telogen stage. Maybe the body hasn't signaled those follicles to move into anogen for whatever reason, or the follicles have become damaged and don't signal the body. Your assumptions are one sided.

                            Comment

                            • gutted
                              Senior Member
                              • Jan 2011
                              • 1397

                              Originally posted by youngin
                              How do you know its an over expression? Maybe its years of pdg2 build up from being stuck in the telogen stage. Maybe the body hasn't signaled those follicles to move into anogen for whatever reason, or the follicles have become damaged and don't signal the body. Your assumptions are one sided.
                              pretty simple



                              we also know theres reports of drug which inhibit cox2 reverse mpb in individuals.




                              mpb is pretty much a hormonal disorder and not genetic(not proven) but blocking dht is not a good pathway to use to stop mpb due to sides etc this new pathway would provide a better option for some.

                              Comment

                              • youngsufferer
                                Member
                                • Jan 2012
                                • 42

                                When (realistically) can all this knowledge be put to practice?

                                I keep hearing 2014 will be the golden year but is there anything actually backing this?

                                Thanks a ton.

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