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exactly! But that mechanism is broken in balding people and I don't think Histogen will be able to TRULY reverse it. Yeah it will be able to mimic those growth factors to simulate another hair phase but that growth is "fake" since your follicle is still "broken" and won't be able to repeat that anagen phase again...
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well to really prove it they would have to do long term studies since anagen hair usually lasts about 2-3 years... a good study to prove their permanent growth effects would be to do this on castrates with NW2 or NW3. Regrow their hairlines with HSC and then come back in 5 years to see if it lastedComment
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LOL!
sorry dude, I have respect for you because I think you are one of the best contributors here, but you think you know better than them at Histogen?
If you think so, I think you should make some phone calls to them and explain the problem.
It'll save a lot of time and the product will be out early.Comment
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and I then proposed: hm... bald scalp == hairs in telogen phase. I wonder if all follicles that are in telogen phase have excess PGD2 and maybe that's what the purpose of PGD2 is: put hair into telogen phase.
Bald scalp === all hairs in telogen phase.
PGD2 === moves hair in telogen phase
And yes, prostaglandins are involved in hair cycling I know that
and I said: Prostaglandins such as PGD2 have DIFFERENT FUNCTIONS throughout the body depending where are they put in.
Just because PGD2 is responsible for inflammation in asthma, doesn't mean that it will be responsible for inflammation in MPB.Comment
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well if that's the truth then we're all ****ed... what makes you think that inflammation won't persist after HSC injections?
I don't think the mechanism is so dumb. PGD2 is simply signaling hair to stop growing and move into telogen phase. I bet if you tested a bald scalp on a castrated person, you would find 3x more PGD2 as well due to his hair being in telogen phase....Comment
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hmm, I thought that theory was that because of inflammation pgd2 is elevated and inhibits hair growth. So if you lower pgd2 hair starts to grow, but inflammation is still presentComment
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well... I think that, unfortunately, this balding process is too complex to be solved just by taking random studies from the internet and doing a lot of guess-work to connect the dots.
It's actually sad that we have to turn ourselves into scientists to figure this shit out just because the real scientists can't solve shit/don't give a shit about us.
but, keep up the good work guys.
About Histogen, we don't even know what they are putting inside the product so how can we speculate what effects it will have and for how long etc ...?
I think they are aware of the fact that if you don't solve the underlaying cause, the new hair won't last long.
Maybe they will put some anti-inflammatory mediators in the product? we have no way to know.
I also think we shouldn't go from excess optimism to except 'we are all ****ed' pessimism. Just let's keep it balanced.Comment
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