If it were PGD2.....

[2020]

dude you cant say that, when hairs are proliferating i.e growing, growth factors are continually being secreted every single day, theres no reason to think histogen will wear off unless you have not addressed your underlying problems.

exactly! But that mechanism is broken in balding people and I don't think Histogen will be able to TRULY reverse it. Yeah it will be able to mimic those growth factors to simulate another hair phase but that growth is "fake" since your follicle is still "broken" and won't be able to repeat that anagen phase again...

[gutted]

ok let's say you get a 1000 histogen injections and now you're a thick NW1. Then you get castrated. Will Histogen's hair fall off eventually? Yes or No?

NO

10char

[gutted]

exactly! But that mechanism is broken in balding people and I don't think Histogen will be able to TRULY reverse it. Yeah it will be able to mimic those growth factors to simulate another hair phase but that growth is "fake" since your follicle is still "broken" and won't be able to repeat that anagen phase again...

NO, once stimulated the body will cycle it normally.

[2020]

NO

10char

for it to be like that, PGD2 has to be THE RESULT of MPB and not really the cause...

someone mentioned that perhaps PGD2 just puts hair into telogen phase and the actual follicle shrinkage is meaningless since follicle size goes up and down depending on the phase?

[2020]

NO, once stimulated the body will cycle it normally.

well to really prove it they would have to do long term studies since anagen hair usually lasts about 2-3 years... a good study to prove their permanent growth effects would be to do this on castrates with NW2 or NW3. Regrow their hairlines with HSC and then come back in 5 years to see if it lasted

[LPSboxing]

Histogen == +1 extra hair cycle which actually sucks really bad I'm not sure if they know it themselves

LOL!

sorry dude, I have respect for you because I think you are one of the best contributors here, but you think you know better than them at Histogen?

If you think so, I think you should make some phone calls to them and explain the problem.

It'll save a lot of time and the product will be out early.

[2020]

LOL!

sorry dude, I have respect for you because I think you are one of the best contributors here, but you think you know better than them at Histogen?

If you think so, I think you should make some phone calls to them and explain the problem.

It'll save a lot of time and the product will be out early.

read my previous posts in this thread. Doesn't my theory make perfect sense? I hope it's not true really but at the moment for me it looks like it might be true...

[gutted]

for it to be like that, PGD2 has to be THE RESULT of MPB and not really the cause...

what are you talking about????

how many times do i have to say it, pgd2 is probably involved in hair follicle cycling!!!

Excess levels are present in balding scalp due to the inflammatory sites within the follcile. Ths is why dr cots found excess pgd2.

[2020]

what are you talking about????

how many times do i have to say it, pgd2 is probably involved in hair follicle cycling!!!

and I then proposed: hm... bald scalp == hairs in telogen phase. I wonder if all follicles that are in telogen phase have excess PGD2 and maybe that's what the purpose of PGD2 is: put hair into telogen phase.

Bald scalp === all hairs in telogen phase.
PGD2 === moves hair in telogen phase

And yes, prostaglandins are involved in hair cycling I know that

Excess levels are present in balding scalp due to the inflammatory sites within the follcile. Ths is why dr cots found excess pgd2.

and I said: Prostaglandins such as PGD2 have DIFFERENT FUNCTIONS throughout the body depending where are they put in.
Just because PGD2 is responsible for inflammation in asthma, doesn't mean that it will be responsible for inflammation in MPB.

[gutted]

Prostaglandins such as PGD2 have DIFFERENT FUNCTIONS throughout the body depending where are they put in.
Just because PGD2 is responsible for inflammation in asthma, doesn't mean that it will be responsible for inflammation in MPB.

inflammation is a major factor in mpb. This has been consistently shown in studies, we also know pgd2 levels are high in inflammtory sites. connect the dots...

just concentrate on inhibiting pgd2 with the pgd2 inhibitor asap.

[2020]

inflammation is a major factor in mpb. This has been consistently shown in studies, we also know pgd2 levels are high in inflammtory sites. connect the dots...

just concentrate on inhibiting pgd2 with the pgd2 inhibitor asap.

well if that's the truth then we're all ****ed... what makes you think that inflammation won't persist after HSC injections?

I don't think the mechanism is so dumb. PGD2 is simply signaling hair to stop growing and move into telogen phase. I bet if you tested a bald scalp on a castrated person, you would find 3x more PGD2 as well due to his hair being in telogen phase....

[ovoxo]

hmm, I thought that theory was that because of inflammation pgd2 is elevated and inhibits hair growth. So if you lower pgd2 hair starts to grow, but inflammation is still present

[LPSboxing]

read my previous posts in this thread. Doesn't my theory make perfect sense? I hope it's not true really but at the moment for me it looks like it might be true...

well... I think that, unfortunately, this balding process is too complex to be solved just by taking random studies from the internet and doing a lot of guess-work to connect the dots.

It's actually sad that we have to turn ourselves into scientists to figure this shit out just because the real scientists can't solve shit/don't give a shit about us.

but, keep up the good work guys.

About Histogen, we don't even know what they are putting inside the product so how can we speculate what effects it will have and for how long etc ...?

I think they are aware of the fact that if you don't solve the underlaying cause, the new hair won't last long.
Maybe they will put some anti-inflammatory mediators in the product? we have no way to know.

I also think we shouldn't go from excess optimism to except 'we are all ****ed' pessimism. Just let's keep it balanced.

[gutted]

well if that's the truth then we're all ****ed... what makes you think that inflammation won't persist after HSC injections?

I don't think the mechanism is so dumb. PGD2 is simply signaling hair to stop growing and move into telogen phase. I bet if you tested a bald scalp on a castrated person, you would find 3x more PGD2 as well due to his hair being in telogen phase....

loooool i give up.

[2020]

loooool i give up.

bald person who was castrated after he went bald. If you measured his PGD2 levels on his bald scalp, would you find PGD2 levels elevated?