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I mean isn't the effect of Rogaine marginal?
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I mean it seems like you are looking at this as a replacement for HT instead of as a replacement for Propecia?Comment
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There are, in fact, 2 problems involved.
Here I explained the 1st problem …
And here is THE main problem explained…
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“…having raised the prospect of being able to augment follicle size by recruitment, is balanced by Tobin's evidence of movement of dermal cells not only within the follicle, but outside to the dermis. In skin undergoing androgenetic alopecia, there is the possibility that the balance of migration is altered and incontinence of dermal sheath cells to the skin dermis leads to reduction in size of the dermal papilla, and in turn to miniaturization of the follicle structure. If this leakage is the result of signals from a dermal environment unique to this region of skin, then addition of cells by recruitment might only be postponing the inevitable.
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The paper is from 2003, sure; but Dr. Colin Jahoda, THE top scientist concernig "hair" on this planet (at least in my opinion), remains still correct today concerning this issue. With "leakage", he is talking about the whole stem cells MICROENVIRONMENT, which tells the cells, signaling dependent and -skin-region-specific- what to do and WHEN they should do something or not (anymore). That's still the problem. And the microenvironment is very difficult to understand, to analyze, and finally, to reproduce. Really so difficult to understand?
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Yes, I still don't understand because I see the picture of the guy with improved hair, and if it takes multiple rounds and postpones the inevitable, then why is it not a Propecia replacement?There are, in fact, 2 problems involved.
Here I explained the 1st problem …
And here is THE main problem explained…
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“…having raised the prospect of being able to augment follicle size by recruitment, is balanced by Tobin's evidence of movement of dermal cells not only within the follicle, but outside to the dermis. In skin undergoing androgenetic alopecia, there is the possibility that the balance of migration is altered and incontinence of dermal sheath cells to the skin dermis leads to reduction in size of the dermal papilla, and in turn to miniaturization of the follicle structure. If this leakage is the result of signals from a dermal environment unique to this region of skin, then addition of cells by recruitment might only be postponing the inevitable.
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The paper is from 2003, sure; but Dr. Colin Jahoda, THE top scientist concernig "hair" on this planet (at least in my opinion), remains still correct today concerning this issue. With "leakage", he is talking about the whole stem cells MICROENVIRONMENT, which tells the cells, signaling dependent and -skin-region-specific- what to do and WHEN they should do something or not (anymore). That's still the problem. And the microenvironment is very difficult to understand, to analyze, and finally, to reproduce. Really so difficult to understand?Comment
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Keep Calm And Carry On
Ya'll need to chill out and understand that if anything positive comes out it will be in the news or on the websites. Stop spending 5 hour a day in this thread.
I remain cautiously optimistic as there are reputable folks out there who have also been affected by MPB. They are doing a lot of work and investors are pouring good money in this research, which means someone's gotta be on to something.
I know this won't make everyone happy in here after the new wave of skepticism I just read. But I recommend everyone just take a step back and hit the bars tonight.
In the meantime, I suggest buzzing the hair really short. I did this for the first time 4 days ago to see approximately what I will look like when bald. Well, girls dig it. Seriously, I would have never imagined it. And I don't even have a fully symmetric, well shaped skull. But yeah, definitely much better than I thought, I had my hair like Ryan Gosling and I wish I could continue to have it that way but, guess what, as long as I look decent I'm good because as it's been repeated a thousand times looks are not all in a man. I got some compliments which makes me feel good and I'm gonna hit the clubs all weekend to see how many phone numbers I can get with the new look. I am optimistic!
So again chill out folks. Stay calm and carry on. If you are really depressed about the new insights on the forum, go out to the bars tonight and have an intense swim tomorrow. Get off the forum for a few days and cool off everyone. And buzz the hair really short, I feel awesome I accepted my self for what I will look like in 2 years and moved on. I don't have the thought in the back of my mind anymore! I'll take propecia twice a week just in case something will come out, and if it doesn't work **** it I already feel good about what I'll look like!Comment
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Sure, in theory YES - with multiple rounds of cell injections and such injections FOREVER. But even so (every 3 or 6 or 12 month cells injections into the balding areas), same as with Propecia:
once the time will come, when not even "postponing the inevitable" will work anymore (if Propecia worked at all for you), because mother nature will be simply stronger. It's simply her intention, so to speak, that you SHOULD be bald in these "unique regions" of the skin - same as those tiger babies I mentioned; they SHOULD have stripes and not prickles or something else instead of.Comment
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How about the following one - it's an easy to understand one (I think)...
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Abstract
Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration.
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These microenvironmental cues dictate stem cell function in both health and disease states. Early progress has been made in elucidating skin compartment-specific niches but a detailed understanding of their molecular and structural biology remains incomplete. Biomaterials will continue to play a central role in regenerative medicine by providing the framework upon which to reconstruct functional niches. Future challenges include the characterization and recapitulation of these dynamic environments using engineered constructs to maximize the therapeutic potential of stem cells.
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"compartment-specific niches" - that's the key point. These are extremely difficult to reproduce. You can them at least "duplicate" (bisectioning of hair follicles etc), but - again, difficult to get 1000s of these necessary "compartment-specific niches". Without them - cells do not really know what they should do (that's the simple version). It's like a snake without a head. With ARI's Ji Gami, the snakes even with a head is still there, but the snake's head are "wrong programmed" - they simply work site-specific (as planned by mother nature). You can feed the worms (miniaturized follicles) with lots of cells, and indeed, the worms will get fatter - but they will always be worms, and not anacondas.Comment
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Solve one problem, get another.
Well, actually I've long toyed with the idea of transplanting some of the hairs from non-permanent zones of the donor area, so that the transplanted hairs would eventually thin out similarly those surrounding them, and I'd always look perfectly au naturelle even if I went balder. No need for ji gami and histogen then, eh?Comment
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yeah, but there is just one giant freaking problem with all those papers. Go back and look at the video. The chart shows hair counts for Ji Gami increasing as the length of time from the procedure increases. In fact it doesn't even hit 60% response until week 54 with the 2011 protocol, and the hair counts are not less at 54 weeks. They are more. The only difference in the 2013 protocol is the response rate starts out much higher which indicates the use of the genetic pre-test but the numbers improve with time in both sets of data.
So when exactly does it stop working because five years sounds like a long time to have more hair to me?Comment
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Sorry for my ignorance but how does everyone know that Aderans isn't using DP cells and what are the implications of this? Has Aderans admitted as much themselves?
I've been looking at some of the comments and I'm not sure what to make of all this. Fortunately I'm still only around a Norwood 1.5/2 and have been receding quite slowly, but I can't style my hairline how I'd like to and I hate that. Hopefully this (or Histogen or Replicel) will come out and enable me to fill in my hairline.Comment
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And then why would the value proposition slide say this...
"Procedural treatment for long term personalized solution rather than ongoing maintenance therapy"Comment
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