Aderans

[Desmond84]

I saw jarjarbinx post this on another forum yesterday. I agree with him quite a fair bit! Imagine if Phase 3 ended up being 6 months, we'd definitely have ji gami availablle by Dec 2014!

"Aderans - could also be a major breakthrough. At minimum Aderans has a solid treatment better than anything on the market. I think they have a shot at being comparable to Histogen. They were producing good results and they were hoping to tweak their results in phase 2 studies. They are still working out the details and they have multiple phase 2 trials ongoing. They are almost done with phase 2 trials. We will be hearing news from them this February, and then it's onto phase 3 and then to market. I think that the results that they have already shown the world from the previous study ascertain that they will be bringing their treatment to market because their already publicized treatment results are already better than anything on the market and their treatment could be improved upon. In other words I have a hunch that their next round of results will be better than the last round of resuls. I also think that that one could use their treatment to get back a lot of hair and then add minoxidil or bimatoprost and improve on those results. Also, unless Follica shows back up in the picture Aderans will probably be the first of the new revolutionary treatments to hit the market - sometime in 2014. It's not out of the realm of possibility that Aderans could turn it's last study (Phase 3) that should start early 2013 into a 6-month study. If they do that then they could release their treatment in late 2013 somewhere in the world. Most likely their last study will be 12 months but it could be just 6 months since their early scientific work involved lengthy studies. Their phase 1 studies were almost 3 years long. The FDA can fast track Aderans treatment since Aderans has gathered a lot of data, they have a revolutionary treatment, their treatment will work on people who presently can't be treated, and people are clamoring for a treatment."

[yeahyeahyeah]

Thinning just read it brother...

if its early stages I reckon just take 0.25mg of Finasteride ONCE A WEEK and see how you tolerate it. If you feel OK after 3 months then it's all good Keep taking it ONCE A WEEK until we get our hands on one of these cutting edge treatments.

Since its early days for you... taking it ONCE A WEEK will really slow things down for you

Hope that's helpful

Do you know anyone aside from you that is doing this with good results?

[StinkySmurf]

Could this be good news for us???

http://dealbook.nytimes.com/2008/05/29/lichtensteins-steel-partners-ousts-board-of-japans-aderans/

Under NEW management, they might be forced to release their product after so many years!!!!

Nice find Desmond! No matter if it was from 2008, it was good info.

Here is the same story playing out exactly one year later in 2009, and this time they were successful in putting Joshua Schechter on the board. Joshua is now chairman of Aderans America. I guess he will be overall the person in charge of the new merged Bosley and Hair Club for Men businesses after Aderans closes the Hair Club deal next month.

[Desmond84]

Do you know anyone aside from you that is doing this with good results?

YEAHYEAHYEAH I'll be honest with you...there are 2 groups of fin users:

1) Can take and tolerate any dose of fin

2) Very sensitive to fin

Taking 1mg daily would give you 20% regrowth and halt all hairloss

Taking 0.25mg EVERY 4-7 days would probably give you 5-10% regrowth and halt/slow down your hairloss.

No one here is planning on taking fin forever! We just want to slow it down till one of these treatments come out in the next 2-3 years.

So, taking low doses would most definitely be a far better option than taking nothing at all.

That's the only reason why I'm taking it anyways. Otherwise changing your hormone profile is just ridiculous.

AND I'm the walking proof that it works! All I can do is share my experiences brother so someone else might benefit...

CHeers

[yeahyeahyeah]

YEAHYEAHYEAH I'll be honest with you...there are 2 groups of fin users:

1) Can take and tolerate any dose of fin

2) Very sensitive to fin

Taking 1mg daily would give you 20% regrowth and halt all hairloss

Taking 0.25mg EVERY 4-7 days would probably give you 5-10% regrowth and halt/slow down your hairloss.

No one here is planning on taking fin forever! We just want to slow it down till one of these treatments come out in the next 2-3 years.

So, taking low doses would most definitely be a far better option than taking nothing at all.

That's the only reason why I'm taking it anyways. Otherwise changing your hormone profile is just ridiculous.

AND I'm the walking proof that it works! All I can do is share my experiences brother so someone else might benefit...

CHeers

But doesn't fin have a short half life?

[Desmond84]

No! we discussed this on another thread...Here's a snapshot of what's important:

"Finasteride has a flat dose response curve meaning taking 0.05mg, 0.2mg and 1mg daily would have exactly the same impact on your scalp DHT profile (which you guys have already realised)

Now, what that means is if you're going to experience sides on 1 mg, you're most likely going to experience sides on 0.05mg. Now, that being said, it may take a bit longer to surface, since its taking a longer period of time to reach a steady state (stabilise in your body). But if its going to happen, it will eventually happen!

So if you're just scared of getting sides and think that taking such a miniscule dose is going to stop that I can promise you that is not the case.

So, my honest opinion is that if you're desperate to try it but scared of sides, break a 1mg tablet into 4 pieces using a tablet cutter and take it 3 times a week (Mon, Wed, Fri). This should give you a good picture of how your body is going to react to this drug. AND BELIEVE ME IT"S STILL VERY EFFECTIVE

Dissolving it in ethanol and all that is fine, but why do it when there's no difference in your body's response. On top of that you're ingesting industrial grade alcohol for no reason at all!

With regards to taking it every other day or 3 times per week, it's safe to do so because of Finasteride's "pharmacological half-life". Now, please note that is different to the plasma half-life which is a measure of a drug's elimination from the body. (50% of finasteride is generally eliminated from your body within 2 hours)

The biological half-life on the other hand, is the point where its pharmacological effect (DHT reduction) is reduced by half. Now, for finasteride that is about 3-7 days, which allows you to take it 2-3 times a week rather than daily.

The reason why it has such a long biological half-life is because it is an IRREVERSIBLE inhibitor of 5-alpha-reductase, meaning that any alpha-reductase it binds to is pretty much deactivated and will no longer serve any purpose. Generally your body takes approximately 3-7 days to reproduce the same amount of 5-alpha-reductase and bring your DHT levels back up to normal. So, you can definitely take advantage of that and take it less often!"

If you want to read the whole discussion, read from Page 7-9. It covers everything

http://www.baldtruthtalk.com/showthread.php?t=10013&page=7

[rdawg]

I saw jarjarbinx post this on another forum yesterday. I agree with him quite a fair bit! Imagine if Phase 3 ended up being 6 months, we'd definitely have ji gami availablle by Dec 2014!

"Aderans - could also be a major breakthrough. At minimum Aderans has a solid treatment better than anything on the market. I think they have a shot at being comparable to Histogen. They were producing good results and they were hoping to tweak their results in phase 2 studies. They are still working out the details and they have multiple phase 2 trials ongoing. They are almost done with phase 2 trials. We will be hearing news from them this February, and then it's onto phase 3 and then to market. I think that the results that they have already shown the world from the previous study ascertain that they will be bringing their treatment to market because their already publicized treatment results are already better than anything on the market and their treatment could be improved upon. In other words I have a hunch that their next round of results will be better than the last round of resuls. I also think that that one could use their treatment to get back a lot of hair and then add minoxidil or bimatoprost and improve on those results. Also, unless Follica shows back up in the picture Aderans will probably be the first of the new revolutionary treatments to hit the market - sometime in 2014. It's not out of the realm of possibility that Aderans could turn it's last study (Phase 3) that should start early 2013 into a 6-month study. If they do that then they could release their treatment in late 2013 somewhere in the world. Most likely their last study will be 12 months but it could be just 6 months since their early scientific work involved lengthy studies. Their phase 1 studies were almost 3 years long. The FDA can fast track Aderans treatment since Aderans has gathered a lot of data, they have a revolutionary treatment, their treatment will work on people who presently can't be treated, and people are clamoring for a treatment."

Wow so you're essentially telling me this could be released THIS YEAR if they fast track it?

obviously that would be europe I suppose, then by summer 2014 in NA.

wow we are close if this is true, Can't wait til we get another product to use! Just on Fin to transition me over.

[Desmond84]

Wow so you're essentially telling me this could be released THIS YEAR if they fast track it?

obviously that would be europe I suppose, then by summer 2014 in NA.

wow we are close if this is true, Can't wait til we get another product to use! Just on Fin to transition me over.

2013 is probably not realistic!

But I'd definitely think if Phase 3 is:

- 6 months --> we should have it by Dec 2014

- 12 months --> by June 2015

All Phase 2 studies will be completed in April 2013!

Uh man... the day I find out they're initiating Phase 3 I will cry

[rdawg]

2013 is probably not realistic!

But I'd definitely think if Phase 3 is:

- 6 months --> we should have it by Dec 2014

- 12 months --> by June 2015

All Phase 2 studies will be completed in April 2013!

Uh man... the day I find out they're initiating Phase 3 I will cry

haha for sure, as in this case, it essentially guarentees a new product on the market within 2 years!

Any info you have on Bim's results? I swear they are very close to phase III as well.

I'd expect 2-3 companies to give us updates around Feb/march.

[Desmond84]

Also, like Jarjarbinx says, Histogen's showing very strong results and is due to be released in 2015 so Aderans is feeling the heat!

They'll be pushing to get their product on the market first big time!

Here's Jarjarbinx's comments:

"Aderans is in phase 2 right now and their phase 2 will be finished in February this year. We're talking about one month here. In their first study they got a 60% success rate and I'm sure they tweaked their treatment and so they will have a better success rate. I thought their pics looked good given the difficulty of reversing hair loss. At any rate, given that they have at least a 60% success rate that means they have a better mouse trap than what is already available. They don't want to sit on it forever. They know Histogen is coming up right behind them. I'm very confident that Aderans will go straight from phase 2 to phase 3 and their phase 3 will likely be one year long, but could be just 6 months long. We will find out in a month or two how long their phase 3 will be. I read that they are already screening for phase 3 patients/subjects. They are almost in phase 3 man. I don't care what people say about 10 years. Their phase 3 will start in a few months and it's not possible to drag phase 3 out for 10 years. Phase 3 will be 6 months to 1 year and that is all. Phase 3 is the last study unless they find a problem with their treatment. People likely say 10 years because they don't want to be accused of over-hyping their treatment."

I love this guy...so positive

[Kiwi]

Wow so you're essentially telling me this could be released THIS YEAR if they fast track it?

obviously that would be europe I suppose, then by summer 2014 in NA.

wow we are close if this is true, Can't wait til we get another product to use! Just on Fin to transition me over.

Desmond84 -- I'm tempted to try .25mg once per week.

HOWEVER as somebody that did experience side effects I'm really ****ing scared. Are you saying that once you got your mojo back you tried 0.25mg per week and havent experienced sides?

I want to keep my mojo forever!!!

[Desmond84]

haha for sure, as in this case, it essentially guarentees a new product on the market within 2 years!

Any info you have on Bim's results? I swear they are very close to phase III as well.

I'd expect 2-3 companies to give us updates around Feb/march.

I know dude 2013 is the year we find out if there's a light at the end of this dark tunnel!

There are so many companies releasing major updates. We're talking:

- Histogen (Feb update re: final 12 month results)

- Aderans (April update re: Final Phase 2 results and Initiation of Phase 3)

- Replicel (November update re: Final 24 month results on Phase 1/2)

- Bimatoprost (Might be launched end of this year!)

- OC (June-July: Phase 2 trials start for baldness)

It's gonna be an epic year! I think the cutting edge section of BTT is gonna be going nuts

[StinkySmurf]

Also, like Jarjarbinx says, Histogen's showing very strong results and is due to be released in 2015 so Aderans is feeling the heat!

They'll be pushing to get their product on the market first big time!

Here's Jarjarbinx's comments:

"Aderans is in phase 2 right now and their phase 2 will be finished in February this year."

I love this guy...so positive

Me Too!

Hey Desmond, I hate to hold you to the fire, but wasn't it your comment or clinical trial link that previously put the completion time at April. Do you really think it will be February?

[rdawg]

Agreed this is probably the biggest year ever in hairloss! The potential to know that 2 or even 3 new products will launch by the end of 2015(2016 at the latest)!

Histogen, Aderans and even Bim excite me alot! And we may find out if all them fully work this year(although Histogen/Aderans have both already shown that IMO!)

[Desmond84]

Desmond84 -- I'm tempted to try .25mg once per week.

HOWEVER as somebody that did experience side effects I'm really ****ing scared. Are you saying that once you got your mojo back you tried 0.25mg per week and havent experienced sides?

I want to keep my mojo forever!!!

Kiwi if you really wanna give it a shot and have had issues b4 try:

0.25mg EVERY 10 days for the first month, then

0.25mg EVERY 9 days for the second month, then

0.25mg EVERY 8 days for the third month, then

0.25mg EVERY 7 days for the fourth month, then

0.25mg EVERY 6 days for the fifth month.

Then just continue taking it every 6 days. This allows your body to produce some DHT between days 4-6 which should hopefully keep you mojo intact.

ATM, instead of every 4 days I'm trying every 6 days for the past 2 weeks see what happens. I'll keep you posted