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It's still hair transplant surgery, and while I can't speak for other people, I know that personally there's no amount of hair loss that could ever convince me to go under the knife just to satisfy my vanity. Maybe it's not rational, but the whole idea of a hair transplant just seems barbaric to me.
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But why no new information on Aderans web site?
And again, why do you think they didn't give several treatments in phase 2?Comment
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Concerning the most recent video on Aderans.. I really do not understand why there is so much negativity in re to the photo results thus far . Those photos show EFFECTIVENESS using the constrained dosages. One of the balding crown photos had shown more hair created on SLICK BALD skin, right?Comment
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If you look at the picture at 10:10 the guys vertex bald area looks pretty much slick bald, and in the after shot he has gained hair even in the very centre of the balding area.
When Washenik stated this would only be for miniaturised follicles I think he was on about that this treatment would unfortunately not work for people with scarring alopecias and burn victims in which the dermal layers have been completely destroyed. Which is disheartening beyond anything when those are the people who deserve this treatment to work for them the most.Comment
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Yeah definitely some minor terminal hair growth on slick bald scalp. And now that that scalp isn't slick bald any more, the blood vessels and fat later are building up again, would this area respond even better to a repeat application after 6 months?
It's not beyond the grounds of possibility. Could Aderans actually get more effective with subsequent treatments?
There would be a limit to the number of biopsies you can have, so hopefully they can keep culturing the original cells for subsequent injections.Comment
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If those are the norwoods they are treating then I am more than happy - because Aderans know this treatment needs to be something that can AID their existing hair transplants - theyve said this all along - you will still need to have a HT but the injections will give you natural density.Comment
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So, after seeing these promising results by Aderans in Phase 2, it is probably time to start talking about what is Ji Gami all about
Ji Gami is a culture of your:
a) Dermal papillae cells, and
b) Keratinocytes
that is extracted from the back of your scalp (1cmx1cm) and is multiplied in the laboratory to millions of cells. These cells are then injected into the balding areas to stimulate hair growth!
Now, the most important question is why are we only using these TWO cells? After all, the hair follicle is a complex organ which is made up of over 11 different types of cells (E.G. outer root sheath, inner root sheath, hair shaft, hair matrix, connective tissue sheath, dermal papilla, etc).
This can be best described by what is the role of these TWO cells:
1) DERMAL PAPILLAE (DP) CELLS
Dermal papillae are small, nipple-like extensions of the dermis into the epidermis. This is what gives you your fingerprints!
In your scalp, DP cells sit right below the hair follicle and contain blood vessels that nourish hair follicles with oxygen and nutrients.
DP cells are involved in the cycle of hair growth and shedding. Now, as most of you may know: The resting phase is known as telogen, the growth phase as anagen and the regression phase as catagen.
During catagen, the epithelial cells at the base of the follicle undergo apoptosis, but the DP remains intact and is pulled or migrates upwards, until it comes to rest next to the stem cells of the hair follicle bulge. This situation persists during telogen. In anagen, cells at the base of the follicle start to proliferate, which results in downward growth of the follicle and envelopment of the DP.
DP cells themselves are thought to not divide. However, the number of cells in the DP increases during anagen, possibly as a result of replenishment from neighbouring cells of the dermal sheath.
Now, here’s some important facts about Dermal Papillae cells:
I. Androgen receptors have only been found in dermal papillae cells of hair follicles. In vitro tests have shown that embedding DP cells (cultivated from androgen sensitive areas) in testosterone significantly shrinks their size, thereby reducing the amount of blood supply to the hair follicle and the launch of an inflammatory caspase response!
II. DP cells remain substantially unaltered (except in size) throughout life. They are formed on day 14 of embryo development and remain the same until you die! This means Aderans treatment will have a PERMANENT effect!
2) KERATINOCYTES
Keratinocytes form the hair itself. Studies in late 90’s found that DP cells can be easily cultured if they are grown on top of Keratinocytes. To my knowledge, that is the only reason Aderans is using these cells. (However, I could be wrong)Comment
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Totally agreed. Anybody going for FUT nowadays is crazy anyway. I feel sorry for everybody with such tremendously ugly scar on the back of their head, which is totally unnecessary anyway. I just uploaded a picture of my donor area shot at the HASCI clinic, right after 'surgery', barely any blood visible, see my album.
Also, surgery is in my opinion WAY safer than taking medication that has known side effects as decreased libido, impotency and depression/suidical thoughts, like Finasteride. I'm vain but not THAT vain that I want to take poison like that ...Comment
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Haha, fair enough. I'm on fin, though too late to save me from needing clever styling to hide my thin patch. That was a panicked reaction, I think - I had a lot of crap going on in my life, I wanted to at least try to control something. I haven't had any negative side effects, so I'm sticking with it, but if I had been more in my present state of mind at the time, I might have just said 'to hell with it', and shaved it all off.Comment
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I must admit, I've been playing with the idea of taking Fin myself, but after reading this article, every single hair on my head was convinced it was a VERY bad idea
http://www.sciencedaily.com/releases...0807101330.htm
44% of the people with persistent sexual sides having suicidal thoughts ? Man, really, that's SO not worth it ...Comment
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