OC000459? (Yes that's its name)

[gutted]

explain why Propecia loses its effectiveness and then try explaining how would that even be possible with PGD2 stuff.

lol why did you leave IH forums? Yesterday they tried solving hair loss with "ocean water" and "hair brushing" and today they're saying that SHOES ARE BAD FOR YOU because it creates more heat in your body thus causing male pattern baldness it's pathetic...

loooool

at best blocking pgd2 provides an extra layer of protection from baldness in conjuction with dht blockers.

To suggest this is a stand alone treatment is not justifiable yet.

pgd2 is probably part of the natrual cycling physiology of the hair.

you want to do some experiments go and read up on benaxoprofen.

[2020]

loooool

at best blocking pgd2 provides an extra layer of protection from baldness in conjuction with dht blockers.

To suggest this is a stand alone treatment is not justifiable yet.

pgd2 is probably part of the natrual cycling physiology of the hair.

you want to do some experiments go and read up on benaxoprofen.

take that crap to IH forums...

blocking PGD2 and raising PGE2 would regrow all your hair. You'll see...

[neversaynever]

in that study they said that testosterone and probably DHT affect ptgds which actually produces PGD2.
PGD2 is known to shrink follicles so that's a fact.
When a person is using DHT blockers, it's pretty obvious to assume to his PGD2 levels also go down a bit otherwise he wouldn't get any regrowth because of PGD2

Interesting, though I feel not conclusive.

In vivo effects of prostaglandin D2 (PGD2) on rat testicular testosterone levels were studied. Testosterone levels were determined by HPLC after 6 hours of PGD2 and of hCG. The testosterone levels were decreased by dose of 500 micrograms/rat intraperitoneal injection. Testis testosterone levels were subsequently decreased by intratesticular injection with PGD2 (1.0 micrograms) into the right testis. The left testis received vehicle alone for control. The increase in testosterone levels induced by hCG (50, 100 and 500 unit/rat s.c.) were also inhibited by intraperitoneal injection of 500 micrograms of PGD2. On the other hand, intratesticular injection of hCG (0.01, 0.1 and 1.0 unit/testis) caused an increase in testosterone levels according to dose of hCG. The increase in testosterone levels by hCG was inhibited by simultaneous injection of PGD2 (1.0 micrograms/testis). These results suggest that PGD2 may play an inhibitory action on LH action in androgen synthesis in the rat testis.

another study i found.

SO PGD2 might be fending of dht...and vice versa. maybe that is the root of the MPB issue? An ancient battle in which our hair is caught in the middle? hahaha.

Im sure its more complicated than that, and ive yet to be convinced, and cant read these studies without my minding bending. So, ill just hope youre right, that DHT increases PGD2, which is the final molecule in the MPB chain that strangles our poor follicles into submission.

One thing makes sense. Fin slows balding, and maybe you'll get some regrowth. So an early to moderate stage of hairloss the PG levels might be high, but not as high as an NW6 or NW7. Therefor, when fin decreases DHT, PGd2 halt where they are. Or at least slow down in increases. If the PGd2 levels are high, but not very high...we might get regrowth.

Glimmer of hope. But just a glimmer

[neversaynever]

loooool

at best blocking pgd2 provides an extra layer of protection from baldness in conjuction with dht blockers.

To suggest this is a stand alone treatment is not justifiable yet.

pgd2 is probably part of the natrual cycling physiology of the hair.

you want to do some experiments go and read up on benaxoprofen.

Yes this is my other thought, that we do need some level of PGD2. Non balding areas do have pgd2, just in lower numbers. So surely blocking it entirely is not restoring the normal balance?

[gutted]

take that crap to IH forums...

blocking PGD2 and raising PGE2 would regrow all your hair. You'll see...

looool
im not saying it wont, but this is far from anything different that current and in development treatments can do, lantanoprost etc

This is probably no gamechanger, hence why dr cots isnt pursuing it. This is probably another potent form of minoxidil.
But anyway i guess if it does work its something to add in addition to the dht blocking.

Also whoever tries it, they need to ONLY use this drug and this drug only.

[gutted]

Yes this is my other thought, that we do need some level of PGD2. Non balding areas do have pgd2, just in lower numbers. So surely blocking it entirely is not restoring the normal balance?

that is probably exactly what it is.
Just part of the hairs normal physiology.

[2020]

OR: PGD2 is there to prevent overgrowth.

[gutted]

OR: PGD2 is there to prevent overgrowth.

what are you talking about.
it was shown in the pubmed article cox enzymes were high in a certain phase and low in another phase. this implies its part of the natrual cycling of the hair.

Minoxidil artificially sorts the prostglandin imbalance out (it puts hairs in the anagen phase permanently) yet it loses effectiveness over time. This is not going to be a permanent solution, but an addition.

something for you to read

http://www.nature.com/labinvest/journal/v82/n11/abs/3780556a.html

http://www.google.com/patents/US4912111

[2020]

what are YOU talking about? why else would PGD2 be there in non-balding people?

[gutted]

why else would PGD2 be there in non-balding people?

what do you mean? pgd2 is present in balding people and non balding people.

i think you need to do more reading into what the function of pgd2 in cells is...

[Conpecia]

Looks like this has fizzled for the time being? A check on the initial link reveals there's been yet another delay. I was really excited about this a month ago, starting to get really skeptical... Hopefully the suppliers pull through and we can hear some good news of results by winter.

[Kirby_]

^ Still possible, IMO. Although it is frustrating playing the waiting game, I agree. Got more confidence in this than anything else we currently know about.

[Davey Jones]

Yeah, I'm still excited by this. After the lab figures out exactly how to get this stuff 99% pure, I don't think the issue will arise again. If it's a methodological issue, they will just do it the right way from now on. If it's a lengthy process issue, they will be able to prepare ahead of time and give accurate dates about availability.

What I like most about reading the other forum's page about this is how skeptical 2020 was at first. Then, after doing some research, he's the internet's number 1 proponent. And after doing some reading, I've got the same good feeling about it.

[Conpecia]

What I like most about reading the other forum's page about this is how skeptical 2020 was at first. Then, after doing some research, he's the internet's number 1 proponent. And after doing some reading, I've got the same good feeling about it.

Yeah me too regarding 2020. But I'll admit that I was really, really crushed by Replicel earlier this year. I hoped that I could just maintain for two or three more years and be cured by 30. That optimism took a real blow with those poor results so now I guess I'm more guarded. It's like I'm right on the fence with a possibility to go my whole life without ever being bald, but my hair gets worse and worse each month. To compound everything I've had horrible sides from fin and unacceptable ones from minox. The clock is really ticking for me. I'd say I have 1-2 years tops before I'm obviously balding to anyone who looks. Gotta have patience but at the same time I'll get a HT before I go slick, no doubt about it. I'm giving these treatments to 2015. After that, Gho time, followed by Shapiro group for the hairline.

[lilpauly]

It's not going to be produced.