OC000459? (Yes that's its name)

[Aston]

It's not a cure in any case, it will probably require daily applications. Plus the patented MPB Prostaglandin treatment is a mix of growth stimulating 'glandins and PGD2 inhibitor(s) and not just the latter. I'm assuming it could be marketed as a daily use shampoo. We also know that androgenic receptors can mutate when inhibited too much, who can tell that won't happen with the PGD2 receptor as well?
I think the most realistic expectation is, as usual, a mix of the best and the worst: a pretty good treatment which requires daily application and can lose effectiveness after a few years, being somewhat expensive as well. Something to look forward too? Definitely, but "the cure"? I seriously doubt it.

Then again, i would be incredibly glad to be proven wrong.

[clandestine]

Speculation remains speculation; patiently we all await.

[gutted]

You keep saying that it has nothing to do with the immune system, you do realize that PGD2 is intimately connected with the immune system don't you? PGD2 is produced by mast cells (involved in the immune system), it then recruits helper t cells, eosinophils and basophils (all white blood cells & part of the immune system). So saying PGD2 is the problem and at the same time saying it has nothing to do with the immune system makes you sound extremely ignorant and uninformed. PGD2 may very well be a critical component to solving hair loss, but to say that's it we have found it, NW7---> NW1 is very irresponsible. Remember how exited everyone got during the lead up to replicel's results and then the crash when their expectations where smashed to shit? There are still many unknown mechanisms and as I have learned through my studies usually when you target or eliminate one variable many unexpected outcomes arise. I like your optimism but I believe it is extremely premature.

i think everyone is just taking 2020's enthusiasm out of proportion...besides its not the "cure" until its fda approved. There is no harm in testing this out, and if it regrows a hair on his hairline, im jumping on it straight away!

[clandestine]

I pray that you're right, and even though I don't share your optimism I thank you for giving this a go, whether it works or not you and the other guys trying this stuff out are doing everyone here a big favor.

If it indeed works, they'll be doing themselves a big favour, too!

[greatjob!]

we will know everything in a couple months! You'll see...

I pray that you're right, and even though I don't share your optimism I thank you for giving this a go, whether it works or not you and the other guys trying this stuff out are doing everyone here a big favor.

[clandestine]

not really a theory....

about to start OC0459 that's why I dropped fin in order to measure my real results

Well, you sound confident. That much is for sure!

[2020]

we will know everything in a couple months! You'll see...

[greatjob!]

it doesn't matter. MPB is not auto-immune or anything so there is no permanent damage.
Your body can make hair grow then shrink then grow back again. It has both of those functions

You keep saying that it has nothing to do with the immune system, you do realize that PGD2 is intimately connected with the immune system don't you? PGD2 is produced by mast cells (involved in the immune system), it then recruits helper t cells, eosinophils and basophils (all white blood cells & part of the immune system). So saying PGD2 is the problem and at the same time saying it has nothing to do with the immune system makes you sound extremely ignorant and uninformed. PGD2 may very well be a critical component to solving hair loss, but to say that's it we have found it, NW7---> NW1 is very irresponsible. Remember how exited everyone got during the lead up to replicel's results and then the crash when their expectations where smashed to shit? There are still many unknown mechanisms and as I have learned through my studies usually when you target or eliminate one variable many unexpected outcomes arise. I like your optimism but I believe it is extremely premature.

[WillhasWill]

not really a theory....
We know that some prostaglandins GROW HAIR and some prostaglandins INHIBIT HAIR GROWTH.
Bald people have more of the prostaglandin that inhibits hair growth.
What do you think will happen once you block that protein? Why wouldn't it start growing? What's stopping it?

----------------
~ NW2

regimen:
toco-8
nizoral 2%
revivogen

about to start OC0459 that's why I dropped fin in order to measure my real results

Please tell me you're not serious? Why wouldn't it start growing? Well, probably for a million reasons that you or I don't know because we are non-scientists. And even they don't necessarily know.

A really relevant and recent example of how theory doesn't always support reality - REPLICEL. The theory is great but it's not as rosy in reality (hopefully they improve on their treatment in their next clinical trials).

A reason why the Replicel boards were full of shit was because there were loads of people like you expecting a black or white answer to a black and white question - Does it work or doesn't it? But you must understand it's not as simple as that. But I see you reacting in a similar way to this finding.

Lets slow the pace down and stop suggesting this is the cure to baldness. As far as I'm aware nothing has been found that PDG2 is an isolated cause of hair loss.

How are you finding your regimen, what results have you had?

[2020]

I really really hope you do :-).

But then again, I'm not saying it won't. The theory sounds brilliant. I just think it's irresponsible to go around making wild accusations that this is the cure to baldness. It is all theory at the moment after all.

By the way what stage of loss are you at and what treatments are you using if any?

not really a theory....
We know that some prostaglandins GROW HAIR and some prostaglandins INHIBIT HAIR GROWTH.
Bald people have more of the prostaglandin that inhibits hair growth.
What do you think will happen once you block that protein? Why wouldn't it start growing? What's stopping it?

----------------
~ NW2

regimen:
toco-8
nizoral 2%
revivogen

about to start OC0459 that's why I dropped fin in order to measure my real results

[25 going on 65]

yeah okay I'll prove you wrong with a full regrowth in a few months

Do it! and keep us updated. The hell with those other forums.

[WillhasWill]

yeah okay I'll prove you wrong with a full regrowth in a few months

I really really hope you do :-).

But then again, I'm not saying it won't. The theory sounds brilliant. I just think it's irresponsible to go around making wild accusations that this is the cure to baldness. It is all theory at the moment after all.

By the way what stage of loss are you at and what treatments are you using if any?

[2020]

Well then my body is lame.

Another question I've thought of... how does PGD2 tie in to DHT? For a long time we thought DHT was the main culprit in genetic hair loss, and there's no doubt that reducing it stops, slows or reverses the process. What's up with that?

not sure although I'm positive that blocking DHT would produce less inflammatory response and therefore less PGD2, so that's why it works....

I think you have been brain washed by the guys at the other forums 2020?

yeah okay I'll prove you wrong with a full regrowth in a few months

[WillhasWill]

I think you have been brain washed by the guys at the other forums 2020?

[25 going on 65]

Well then my body is lame.

Another question I've thought of... how does PGD2 tie in to DHT? For a long time we thought DHT was the main culprit in genetic hair loss, and there's no doubt that reducing it stops, slows or reverses the process. What's up with that?