OC000459? (Yes that's its name)

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  • WillhasWill
    Member
    • Mar 2012
    • 54

    I think you have been brain washed by the guys at the other forums 2020?

    Comment

    • 2020
      Senior Member
      • Jan 2012
      • 1513

      Originally posted by 25 going on 65
      Well then my body is lame.

      Another question I've thought of... how does PGD2 tie in to DHT? For a long time we thought DHT was the main culprit in genetic hair loss, and there's no doubt that reducing it stops, slows or reverses the process. What's up with that?
      not sure although I'm positive that blocking DHT would produce less inflammatory response and therefore less PGD2, so that's why it works....

      Originally posted by WillhasWill
      I think you have been brain washed by the guys at the other forums 2020?
      yeah okay I'll prove you wrong with a full regrowth in a few months

      Comment

      • WillhasWill
        Member
        • Mar 2012
        • 54

        Originally posted by 2020
        yeah okay I'll prove you wrong with a full regrowth in a few months
        I really really hope you do :-).

        But then again, I'm not saying it won't. The theory sounds brilliant. I just think it's irresponsible to go around making wild accusations that this is the cure to baldness. It is all theory at the moment after all.

        By the way what stage of loss are you at and what treatments are you using if any?

        Comment

        • 25 going on 65
          Senior Member
          • Sep 2010
          • 1476

          Originally posted by 2020
          yeah okay I'll prove you wrong with a full regrowth in a few months
          Do it! and keep us updated. The hell with those other forums.

          Comment

          • 2020
            Senior Member
            • Jan 2012
            • 1513

            Originally posted by WillhasWill
            I really really hope you do :-).

            But then again, I'm not saying it won't. The theory sounds brilliant. I just think it's irresponsible to go around making wild accusations that this is the cure to baldness. It is all theory at the moment after all.

            By the way what stage of loss are you at and what treatments are you using if any?

            not really a theory....
            We know that some prostaglandins GROW HAIR and some prostaglandins INHIBIT HAIR GROWTH.
            Bald people have more of the prostaglandin that inhibits hair growth.
            What do you think will happen once you block that protein? Why wouldn't it start growing? What's stopping it?

            ----------------
            ~ NW2

            regimen:
            toco-8
            nizoral 2%
            revivogen

            about to start OC0459 that's why I dropped fin in order to measure my real results

            Comment

            • WillhasWill
              Member
              • Mar 2012
              • 54

              Originally posted by 2020
              not really a theory....
              We know that some prostaglandins GROW HAIR and some prostaglandins INHIBIT HAIR GROWTH.
              Bald people have more of the prostaglandin that inhibits hair growth.
              What do you think will happen once you block that protein? Why wouldn't it start growing? What's stopping it?

              ----------------
              ~ NW2

              regimen:
              toco-8
              nizoral 2%
              revivogen

              about to start OC0459 that's why I dropped fin in order to measure my real results
              Please tell me you're not serious? Why wouldn't it start growing? Well, probably for a million reasons that you or I don't know because we are non-scientists. And even they don't necessarily know.

              A really relevant and recent example of how theory doesn't always support reality - REPLICEL. The theory is great but it's not as rosy in reality (hopefully they improve on their treatment in their next clinical trials).

              A reason why the Replicel boards were full of shit was because there were loads of people like you expecting a black or white answer to a black and white question - Does it work or doesn't it? But you must understand it's not as simple as that. But I see you reacting in a similar way to this finding.

              Lets slow the pace down and stop suggesting this is the cure to baldness. As far as I'm aware nothing has been found that PDG2 is an isolated cause of hair loss.

              How are you finding your regimen, what results have you had?

              Comment

              • greatjob!
                Senior Member
                • Aug 2011
                • 909

                Originally posted by 2020
                it doesn't matter. MPB is not auto-immune or anything so there is no permanent damage.
                Your body can make hair grow then shrink then grow back again. It has both of those functions
                You keep saying that it has nothing to do with the immune system, you do realize that PGD2 is intimately connected with the immune system don't you? PGD2 is produced by mast cells (involved in the immune system), it then recruits helper t cells, eosinophils and basophils (all white blood cells & part of the immune system). So saying PGD2 is the problem and at the same time saying it has nothing to do with the immune system makes you sound extremely ignorant and uninformed. PGD2 may very well be a critical component to solving hair loss, but to say that's it we have found it, NW7---> NW1 is very irresponsible. Remember how exited everyone got during the lead up to replicel's results and then the crash when their expectations where smashed to shit? There are still many unknown mechanisms and as I have learned through my studies usually when you target or eliminate one variable many unexpected outcomes arise. I like your optimism but I believe it is extremely premature.

                Comment

                • 2020
                  Senior Member
                  • Jan 2012
                  • 1513

                  we will know everything in a couple months! You'll see...

                  Comment

                  • clandestine
                    Senior Member
                    • Aug 2011
                    • 2002

                    Originally posted by 2020
                    not really a theory....

                    about to start OC0459 that's why I dropped fin in order to measure my real results
                    Well, you sound confident. That much is for sure!

                    Comment

                    • greatjob!
                      Senior Member
                      • Aug 2011
                      • 909

                      Originally posted by 2020
                      we will know everything in a couple months! You'll see...
                      I pray that you're right, and even though I don't share your optimism I thank you for giving this a go, whether it works or not you and the other guys trying this stuff out are doing everyone here a big favor.

                      Comment

                      • clandestine
                        Senior Member
                        • Aug 2011
                        • 2002

                        Originally posted by greatjob!
                        I pray that you're right, and even though I don't share your optimism I thank you for giving this a go, whether it works or not you and the other guys trying this stuff out are doing everyone here a big favor.
                        If it indeed works, they'll be doing themselves a big favour, too!

                        Comment

                        • gutted
                          Senior Member
                          • Jan 2011
                          • 1397

                          Originally posted by greatjob!
                          You keep saying that it has nothing to do with the immune system, you do realize that PGD2 is intimately connected with the immune system don't you? PGD2 is produced by mast cells (involved in the immune system), it then recruits helper t cells, eosinophils and basophils (all white blood cells & part of the immune system). So saying PGD2 is the problem and at the same time saying it has nothing to do with the immune system makes you sound extremely ignorant and uninformed. PGD2 may very well be a critical component to solving hair loss, but to say that's it we have found it, NW7---> NW1 is very irresponsible. Remember how exited everyone got during the lead up to replicel's results and then the crash when their expectations where smashed to shit? There are still many unknown mechanisms and as I have learned through my studies usually when you target or eliminate one variable many unexpected outcomes arise. I like your optimism but I believe it is extremely premature.
                          i think everyone is just taking 2020's enthusiasm out of proportion...besides its not the "cure" until its fda approved. There is no harm in testing this out, and if it regrows a hair on his hairline, im jumping on it straight away!

                          Comment

                          • clandestine
                            Senior Member
                            • Aug 2011
                            • 2002

                            Speculation remains speculation; patiently we all await.

                            Comment

                            • Aston
                              Member
                              • Apr 2012
                              • 82

                              It's not a cure in any case, it will probably require daily applications. Plus the patented MPB Prostaglandin treatment is a mix of growth stimulating 'glandins and PGD2 inhibitor(s) and not just the latter. I'm assuming it could be marketed as a daily use shampoo. We also know that androgenic receptors can mutate when inhibited too much, who can tell that won't happen with the PGD2 receptor as well?
                              I think the most realistic expectation is, as usual, a mix of the best and the worst: a pretty good treatment which requires daily application and can lose effectiveness after a few years, being somewhat expensive as well. Something to look forward too? Definitely, but "the cure"? I seriously doubt it.

                              Then again, i would be incredibly glad to be proven wrong.

                              Comment

                              • gutted
                                Senior Member
                                • Jan 2011
                                • 1397

                                Originally posted by Aston
                                It's not a cure in any case, it will probably require daily applications. Plus the patented MPB Prostaglandin treatment is a mix of growth stimulating 'glandins and PGD2 inhibitor(s) and not just the latter. I'm assuming it could be marketed as a daily use shampoo. We also know that androgenic receptors can mutate when inhibited too much, who can tell that won't happen with the PGD2 receptor as well?
                                I think the most realistic expectation is, as usual, a mix of the best and the worst: a pretty good treatment which requires daily application and can lose effectiveness after a few years, being somewhat expensive as well. Something to look forward too? Definitely, but "the cure"? I seriously doubt it.

                                Then again, i would be incredibly glad to be proven wrong.
                                its possible it may require daily use, but again its also possible it may not require daly use, only until the hairs have been allowed to regenerate.

                                i think minox and propecia have put a misconception into peoples heads that whatever they use for baldness needs to be used for life, which is the case for minox but possibly not the case for propecia.

                                heres a patent that explains the use of antibiotics to fight hair loss, but the intresting thing the inventor notes is that it only needs to be used for a limited time, not for life.


                                PatentStorm is a database and reference site containing information about current, pending, and expired U.S. and world patents.


                                i think the guys on the other forum trying this out also need to address their scalp health also, nizoral may suffice.


                                once MPB is finally figured out, i see products being released which will reverse baldness/thinning and will NOT neccasarily need to be used for life however maintenance sessions may be needed if you experience subsequent thinng.

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