OC000459? (Yes that's its name)

[yeahyeahyeah]

After finally taking a look at the Histogen results and pictures, I let out a huge sigh of relief. Cosmetically significant regrowth without adverse sides. Hopefully the growth cycle issue can be resolved by simply receiving more injections.

I've gotten really negative ever since having to get off finasteride, but I do think we'll be ok eventually (within this decade). The question is how long. If it's 2015-16, I'm cool with that. Anything later and I may have to take more drastic measures.

I will go to gho if HSC/or a good alternative treatment is not out by then.

[yeahyeahyeah]

How long is a hair cycle?

[neversaynever]

So this "PGD2 blocking" lotion is not happening.
Histogen looks bad lately with what 2020 said about it offering only one hair cycle.
Replicel failed.
Aderans is so far away and their results look like Replicel's...

What's left? Seriously...

not long ago 2020 was saying that histogen is without doubt the cure. Now hes saying without doubt, it will give us only one cycle.

Im saying to you, even if its just one cycle (worst case) then be happy! The price should be pretty competitive. Repeat treatments...

But it is also likely that it could be more than one cycle. For all we know, HSC might be getting the cells to trigger anagen phase again, and in doing so, the cells reduce pgd2 levels. it might take a few cycles before pgd2 levels are high enough to put a follicle to sleep, just like the balding process all over again (which is certainly not just one cycle!).

A bigger concern with histogen is when they will release HSC. Again, people have been swearing blind that its 2014...i never saw this as realistic. I think it will be closer to 2016.

Ive yet to see any reason to make me believe in any of the cell treatments. Plus they will be mega expensive. Thats the big one, and the longer shot.

SO our attention comes to PGD2. Since the PGd2 issue was broadcast by Dr Cots, everyone has been obsessed with it. Dr Cots, I believe in the name of money....has said that a pgd2 blocker may work. But if you read about it, PGd2 levels are a double edged sword.

PGd2 levels seem to be high because its an anti-imflamatory, but it also seems that PGd2 is involved in a hairs telogen phase. We need it for both those reasons....

Blocking MIGHT yield some results, but there is NO proof of this so far. And there is no news of any company looking to tackle it for hairloss.

SO, where do we turn to next? PG levels seem to be a key. The final piece, even though we're missing other pieces before it. Allergen...

Allergens testing a PGf2a analog, which studies have shown has more influence on moving a hair from telegon to anagen, than pge2. PGe2 becomes more important in moving the hair through the anagen phase.

Allergen is a big hope, they will show phase 2 results very soon, and have the business and money to get it to market.

What ever people say, histogen are getting great stats from their trials. Which means their HSC must be acting on PG levels, otherwise hair will not grow! Unfortunately we have no idea how HSC is effecting pg levels. Im very curious about this, and very curious to know if they are curious about this...

Gho has potential, but hes expensive and not everyone is a suitable HST patient. All depends how your 2 and 3 hair grafts are spread out.

There are positives, but we are not scientists, so we just have to wait. By the time HSC comes, I'll be an nw5-6, unless i go onto fin. Which ive decided to do, just for a year (but if i get sides im stopping straight away). Just until I know whats happening with allergen, histogen, and the long shots...ari and replicel.

Good luck people.

[Conpecia]

you are wrong - HSC will be out in 3 years MAX.

After finally taking a look at the Histogen results and pictures, I let out a huge sigh of relief. Cosmetically significant regrowth without adverse sides. Hopefully the growth cycle issue can be resolved by simply receiving more injections.

I've gotten really negative ever since having to get off finasteride, but I do think we'll be ok eventually (within this decade). The question is how long. If it's 2015-16, I'm cool with that. Anything later and I may have to take more drastic measures.

[hellouser]

Can somebody elaborate on the Histogen cycle thing?

Sorry but I havent been on the forum in a bit and missed it.

Thanks

J

I'm curious about this as well.

Also, can anyone give us an explanation of how OC000459 fares against RU58841? Which is better for regrowing hair?

[Jairus]

Can somebody elaborate on the Histogen cycle thing?

Sorry but I havent been on the forum in a bit and missed it.

Thanks

J

[Aston]

Various PGD2 inhibitors are being researched. Even OC000459 can still happen if a less incompetent compounding service works on it. There are other already known PGD2 inhibitors as well.

[ccmethinning]

Gho is left. Yes it is expensive, and no it probably won't give you a NW0 Elvis mane, but it serious looks like Gho is the next intermediate step in hair restoration progress.

If people want hair, they need to start pressuring more surgeons to offer HST. Let's keep the HST awareness movement going.

[Gjm127]

So this "PGD2 blocking" lotion is not happening.
Histogen looks bad lately with what 2020 said about it offering only one hair cycle.
Replicel failed.
Aderans is so far away and their results look like Replicel's...

What's left? Seriously...

[BaldinLikeBaldwin]

It's not going to be produced.

had to happen

[2020]

yeah the lab couldn't produce it at 99% purity. Best they could do is 80% which is not good enough.
There are other labs but they are way too expensive....

[yeahyeahyeah]

Jesus Christ. Is there no hope for us? I am starting to think a cure won't be available for another 10-15 years. Think about it: there is still absolutely nothing on the market that works better than fin and minox, both of which have been around for decades. I just need something besides those that can preserve the hair I have left so I can get a hair transplant without losing the hair behind the transplanted hair. Apparently that's impossible...

you are wrong - HSC will be out in 3 years MAX.

[Gjm127]

It's not going to be produced.

Are you serious? Why?

[Conpecia]

It's not going to be produced.

Jesus Christ. Is there no hope for us? I am starting to think a cure won't be available for another 10-15 years. Think about it: there is still absolutely nothing on the market that works better than fin and minox, both of which have been around for decades. I just need something besides those that can preserve the hair I have left so I can get a hair transplant without losing the hair behind the transplanted hair. Apparently that's impossible...

[lilpauly]

It's not going to be produced.