CB-03-01 - new antiandrogenic

[MindfluX]

Although in the drug's defence they are doing a dose ranging study next so a higher dose could prove to be much better.

I am familiar with research chemicals, but none of these compounds have an effect on the hair. Effects are mostly lineair, but some are logarithmic: a double amount of compound multiplies the effect eight times for instance.

You never know ;-)

Do you know the amount they used now?

[potato1987]

I was a bit hopeful it would do maintenance but the results show some people worse off? PER-PROTOCOL (N=23) (N=25) (N=25) 0.2213
CB MIN Vehicle
-1=SLIGHTLY DECREASED 5 ( 21.7%) 1 ( 4.0%) 8 ( 32.0%) .
-2=MODERATELY DECREASED 1 ( 4.3%) 2 ( 8.0%) 2 ( 8.0%) .
-3=GREATLY DECREASED 0 ( 0.0%) 1 ( 4.0%) 0 ( 0.0%)

any thoughts?

[Tenma]

This is from their recent press release:

"As for mean increase in TAHC at Month 6 (12.70 Breezula® vs. 18.8 Minoxidil®), it should be considered that the treatment per protocol was 6 months and that it is known that antiandrogens (such as Propecia®) show maximum efficacy at 12 months, while it is also known that Minoxidil® has its efficacy peak at 4 months, so the data were as expected.

Given the patients sample size (30 per group) the study was not powered to show statistical superiority at this stage.

Diana Harbort, CEO, said: “I am more than happy with these results. Our objective is to develop an efficacious topical antiandrogen product without limiting side effects and with the ability of being used by both men and women. The clinical data are in line with our hopes. Now we are very much looking forward to taking Breezula® into phase II dose ranging studies as quickly as possible”.

[Tenma]

I agree with the company. 6 months is too early for antiandrogen to display maximum effect

But we must keep in mind what cb really is: a topical androgen antagonist, nothing more, nothing less...

Even castration was unable to regrow hair on most of the eunuchs:

http://www.ncbi.nlm.nih.gov/pubmed/13711016

I think cb real value comes when combined with Dut or Fin (alpa reductase inhibition) , because it works by a complementary mechanism (receptor blockage)

[joshuk]

the fact that CB-03-01 regrew hair is impressive since anti androgens are for keeping hair not regrowth. i have just started back on CB at 40-50mg a day, so i guess i will report back in 6 months then. im not using minox but i am using chemical's wnt/b catean findings found further down on the cutting edge page.

[machi]

Joshuk , Can you explain your treatment? How long have you been with CB -03-01 ? Do any effect , less hair loss ? Can you explain what use about wnt/b catean? I was hopeful that cb worked but after yesterday's results I have doubts. I need to use any drugs to keep my hair .
Does anyone use CB some time with good results ?

[burtandernie]

An AA that helps both men and women with few probably minor sides? Sounds like a for sure winner to me. Also you have to wonder could it be used to stop or prevent body hair? Im curious if someone applied RU to their beard what happens? In theory RU or CB should do something there or prevent it from happening. RU and CB both compete with T not just DHT so you would expect it to stop or slow beard hair/body hair too

[burtandernie]

Ah they released new results? I wouldnt throw out CB just yet. The dosing might yield better results, it works on women, and it might stack with fin to combat DHT from two angles doing a much better job than fin or even dut alone. If it has any efficacy I think they should keep going with it. Hopefully the dosing will increase the results. Also like they said it might take 12 months, and once MPB starts its arguable if an AA still for sure stops it. You need to take it before it gets going, but everyone is so worried about sides from propecia they delay it until absolutely needed. This might solve that
I dont think anyone ever expected results unlike fin or dut but CB is way safer to use long term.

[Guildenstern]

The results are a huge step backwards. It was barely as efficient as Minox.

While i am always happy to see something new, it just feels too weak. A mean increase in 13 hairs over the whole period of the study?
I guess you could indeed use this in synergy with Minox to achieve a better effect. Customers will love to now smear 2 topicals on their heads for a mean increase of 25% hair density. yay.

I still don't really understand why they had to switch to a lousy 'vehicle'. The results in their POC study using iontophoresis were really strong - really, really strong. Yet again, nobody will buy a compound, a machine, and use a time consuming and expensive procedure to keep their hair. At least nobody who's right in the head. I have no dount anyone here would do it. Personally, i'd do it instantly.

And let's not forget this whole thing is still a grand mystery. Wasn't there a chemist or biologist who claimed it would be exceptionally hard to get this specific molecule into your dermis using just iontophoresis, because it had no loading site or something? Now they have encapsulated their pure-golden molecule into a super crappy cream or whatever-based vehicle that isn't working. Well done.

[Trouse5858]

lol 13 hairs. Impossible to argue its worth smearing shit on your head evryday for such an embarrassing result

[Seuxin]

Warning, they used at 5%, but maybe CB-03-01 should be used at 7-10%.
If CB is really able to inhibe AR Receptor it should work !

[Xoxo]

lol 13 hairs. Impossible to argue its worth smearing shit on your head evryday for such an embarrassing result

Well, isn't the focus on maintaining hair instead of regrowth? Then, it might be judged too quickly. Maybe you can keep your hair better with CB than with Minox in the long run. But I'm no expert. Someone with more knowledge should anser on that.

[Tenma]

Well, isn't the focus on maintaining hair instead of regrowth? Then, it might be judged too quickly. Maybe you can keep your hair better with CB than with Minox in the long run. But I'm no expert. Someone with more knowledge should anser on that.

Antiandrogens show its true benefits at the 8-12 months mark.

There is broad consensus on that.

The dose ranging study will provide good evidence about what breezula can really do for us.

That said, i think RU is at least as good as CB, so im not really that nterested about the CB

[burtandernie]

Lets see other dosage results. Lets see results at 12 month mark before condemning the stuff as worthless. Since its topical you might be able to achieve much stronger doses than would be possible going internal. I will say this I do think the vehicle plays a HUGE role in all these topical results. Topical spiro might stop MPB dead in its tracks if delivered properly. The thing is there are topical delivery systems that are very very good so I wonder if they used one of those or tried different ones to compare. That one company was delivering igf-1 with some amazing new topical delivery system why not use that?
No one has any clue if RU is safe though. Thats a pretty big issue. There are androgen receptors all over your entire body even organs maybe. Do you want receptors all over getting shut down that arent in your scalp? Could cause major issues over many years who knows, but its hard to believe it doesnt go systemic at all

[Follisket]

Well, isn't the focus on maintaining hair instead of regrowth?

In 2016? Definitely. But in 2022 ... ?