CB-03-01 - new antiandrogenic

[KO1]

https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0031-1297043

Summary

The aim of this study was to investigate the antiandrogenic activity of a new monoester of cortexolone, cortexolone 17α-propionate (CAS 19608-29-8, CB-03-01). Although the compound displayed a strong local antiandrogenic activity in hamster's flank organ test, it did not exhibit antiandrogenic activity in rats after subcutaneous injection, nor did it affect gonadotropins hypersecretion when injected to parabiotic rats. As topical antiandrogen, the steroid resulted about 4 times more active than progesterone (CAS 57-83-0) and, when compared to known antiandrogen standards, it was about 3 times more potent than flutamide (CAS 13311-84-7), about 2 times more effective than finasteride (CAS 98319-26-7) and approximately as active as cyproterone acetate (CAS 427-51-0). Its pharmacological activity seemed to be primarily related to its ability to antagonistically compete at androgen receptor level; nevertheless its primary pharmacological target needs to be further investigated. Its topical activity, along with the apparent absence of systemic effects, anticipates this compound to have the potential of representing a novel and safe therapeutic approach for androgen-de-pendent skin disorders.

This paper is from 2004 btw. The key is that it should be locally antiandrogenic ONLY.

[yan]

It blocks the androgen receptors for about a week before being washed away, hence once weekly dosing

Where did you read that it blocks receptors for about a week? They applied it twice weekly in the alopecia tests and in acne tests once daily. If true, CB would be even more amazing. Wow just imagine, you spend 10 min a week and keep your hair forever. In my opinion, this is nearly a cure for low norwoods.

I guess they use it once daily for acne bcs of its anti-inflammatory properties? Wouldn't make sense to use it daily if receptors are blocked for a week.

[Hairismylife]

https://www.thieme-connect.com/ejour...s-0031-1297043



This paper is from 2004 btw. The key is that it should be locally antiandrogenic ONLY.

Then it should be unsystematic? Glad to here that if it's true

Btw, I just think of a question. Now the problem of CB is the vehicle is not so penetrating compared to Cosmo Ion method. Say, 50% less penetrating, so if I double the concentration, I should have the same amount of CB reaching my receptor achieving the same effect. Any conceptual error?

[hellouser]

Then it should be unsystematic? Glad to here that if it's true

Btw, I just think of a question. Now the problem of CB is the vehicle is not so penetrating compared to Cosmo Ion method. Say, 50% less penetrating, so if I double the concentration, I should have the same amount of CB reaching my receptor achieving the same effect. Any conceptual error?

I think doubling the dosage wouldnt give the desired results as Cosmo, probably a little more complicated than that...

[hellouser]

Ionopheresis is a device that costs $200-$300 and tbh I'm not quite sure how to use it! Has anyone actually tried the ionopheresis method btw?

P.S. No question is stupid to ask? That's why we're here brother

You can make your own ionopheresis device for much less. Check out some youtube tutorial videos.

[Scoots]

So on the iron dragon website it says they will be selling cb in 5 weeks (Cortexone 17 alpha propionate)...anybody think the vehicle they will be mixing it with will be the right one?

[Hairismylife]

So on the iron dragon website it says they will be selling cb in 5 weeks (Cortexone 17 alpha propionate)...anybody think the vehicle they will be mixing it with will be the right one?

Are u sure they are selling pre-mixed CB?

[KO1]

It is a solution, and it is going to be in either Ethanol or DMSO.....

[simba]

It is a solution, and it is going to be in either Ethanol or DMSO.....

And are these the right vehicles?

[burtandernie]

Where did you read that it blocks receptors for about a week? They applied it twice weekly in the alopecia tests and in acne tests once daily. If true, CB would be even more amazing. Wow just imagine, you spend 10 min a week and keep your hair forever. In my opinion, this is nearly a cure for low norwoods.

I guess they use it once daily for acne bcs of its anti-inflammatory properties? Wouldn't make sense to use it daily if receptors are blocked for a week.

Yeah I agree here if they find a vehicle that works well, nothing weird comes up, its priced reasonably, and its once a week then this could really be a preventative cure. A preventative cure that is safe is really important. If you cant keep hair your going to be getting expensive transplants or whatever they come up with periodically forever. We need better prevention that is safe and we dont have it now.

[burtandernie]

If your not worried taking a hormone altering drug for 20 years then you lack common sense about how internal drugs work because how they work exactly no one knows. This CB 03 01 is possibly a safe much more effective way to keep hair. Cant come soon enough. Every year we have to wait is a year too long.
I just really hope they see this through financially and its priced realistic. Im worried its going to cost a ton.

[simba]

If your not worried taking a hormone altering drug for 20 years then you lack common sense about how internal drugs work because how they work exactly no one knows. This CB 03 01 is possibly a safe much more effective way to keep hair. Cant come soon enough. Every year we have to wait is a year too long.
I just really hope they see this through financially and its priced realistic. Im worried its going to cost a ton.

Well Kane is selling non mixed cb for super cheap, I doubt the vehicle would cost all that much. It just needs to be our NOW

[Conpecia]

we have to get the dosage and vehicle down pat. this is the savior for guys like me and clandestine.

[thechamp]

Are you forgetting thechamp also is cb safe ?

[Cob984]

well iv been on CB form 3 in kb solution at around 15 mg daily for a few weeks,
it doesnt seem to be doing much,
im also on RU 10-15 mg daily but thats too low a dose,
I tried I/C indo is bs, it makes my scalp itch like mad, chromo is v good in that my hair looks better immediately unfortunately i get huge dark circles under my eyes, it fks my face up so i had to drop it,
I am on ramotraban and topical cet daily which do a little but not much,

So thats my update, hairloss not stopped, temples still receding, FML