CB-03-01 - new antiandrogenic

[hellouser]

Guys why aren't we focusing on the fact that we HAVE CB NOW?? Meaning we need to find the correct vehicle and dosage. We also need to see how much CB is in what Iron Dragon is selling. Waiting until 2016 seems strange when it's allegedly right here...

I'm curious how much CB you actually get for $45 from Iron Dragon.

But I fully agree. I'm gonna be trialing CB with Oleyl/PG

[simba]

Even if it hits shelves for acne, the vehicle will be anhydrous for hair loss, which is 1-2 years after the acne product.

Pretty fvcking dumb of cosmo to release a product for acne when theres so much stuff for that issue and so many more men suffering from hair loss and so much more SHIT on the market that doesnt work.

Youve said itll be an "anhydrous" vehicle a few times now but I dont know what that means, could you explain? Im guessing it just means a cream instead of a liquid.

[yan]

Youve said itll be an "anhydrous" vehicle a few times now but I dont know what that means, could you explain? Im guessing it just means a cream instead of a liquid.

Its anhydrous if it contains no water. It dont have to be a cream. A cream will most probably not work on the head and it would be a big mess to apply it in your hair.

[hellouser]

Its anhydrous if it contains no water. It dont have to be a cream. A cream will most probably not work on the head and it would be a big mess to apply it in your hair.

Would be pretty fvcking AWESOME if it we're completely dry. Just apply CB and then style hair. Use Minoxidil at night and you've got an awesome one-two punch. Dermarolling once a week shold give results as well.

[yan]

Would be pretty fvcking AWESOME if it we're completely dry. Just apply CB and then style hair. Use Minoxidil at night and you've got an awesome one-two punch. Dermarolling once a week shold give results as well.

Indeed! I hope so much all goes well...

[hellouser]

Indeed! I hope so much all goes well...

There's also this which contains saw palmetto:

http://www.folica.com/hair-care/hair-protection-products/min-new-york-substance-texturizing-paste-three-five-oz

I doubt it will do much, if at all, but saw palmetto being there is better than the regular crap that we use normally.

[Conpecia]

def start a trial thread on the CB hellouser, good luck dude. when is it supposed to arrive?

[hellouser]

def start a trial thread on the CB hellouser, good luck dude. when is it supposed to arrive?

I need help ordering and paying on Kane's website. Its so confusing... nothing is explained on how to pay.

[yan]

Btw regarding the safety:

Phase 2 European Pilot study for acne: http://intrepidthera.com/wp-co...2011-Trifu-et-al-.pdf

"During the study, no concerns were raised regarding the local and systemic safety of CB-03-01."

"No serious AEs were detected through the study, no drop-outs occurred for safety reasons, and no differences among the groups were noticed concerning the nature and the incidence of AEs."

They applied 1% CB once daily for 8 weeks.

[yan]

Effectiveness of two vehicles for CB-03-01:


On human skin, in vitro:

~1% CB in Propylene Glycol has an average:

Permeation Rate of 7
Skin concentration of 36


~1% CB in Propylene Glycol and Oleyl Alcohol 9.1 has an average:

Permeation Rate of 1410
Skin Concentration of 231


http://files.investis.com/csm/presen.../RDday2010.pdf - Page 74

On page 7 you can see the timeline they had in 2010. They planned to finish the proof of concept for the alopecia formulation in H1 / 2013. Timeline slipped two years since 2010.. :/

[thechamp]

Do you think cb will be effective ?

[deuce]

Do you think cb will be effective ?

I HOPE it does work for everyones sake. Only thing is I have not seen one person report its effectiveness because no one can find the proper vehicle for it. I am not an expert on mixtures and stuff so I am not sure. What makes yall think it will work this time around?

[thechamp]

How can we find the vehicle

[simba]

Effectiveness of two vehicles for CB-03-01:


On human skin, in vitro:

~1% CB in Propylene Glycol has an average:

Permeation Rate of 7
Skin concentration of 36


~1% CB in Propylene Glycol and Oleyl Alcohol 9.1 has an average:

Permeation Rate of 1410
Skin Concentration of 231


http://files.investis.com/csm/presen.../RDday2010.pdf - Page 74

On page 7 you can see the timeline they had in 2010. They planned to finish the proof of concept for the alopecia formulation in H1 / 2013. Timeline slipped two years since 2010.. :/

Im guessing this means Propylene Glycol and Oleyl Alcohol are perfect vehicles?

[huawei]

Hey all, a few days ago Cosmo released a financial report for shareholders which is available on their site.

The two key points relating to this drug are as follows

1. Phase II trials are half done for CB-03-01 but only for acne.
2. Phase I trials for CB-03-01 for MPB are about 80% done.

Here's in only info available in the doc relating to the Phase I:

Phase I alopecia
•Completion of toxicological studies ongoing
•Phase I PK ongoing (treatment completed)

so it's safe to say that if it goes to phase 2 saftey of the product is pretty much assured for all you clandestine hair loss fighters.