Anyone planning on taking the *new* Hasson and Wong liposomal topical fin?

[mowingdown]

If you do we would be forever grateful for your part in getting bloodwork done BEFORE you start the cream. I would love to get it but alas, I am in the US. If you do plan on using this please please please get your serum DHT checked prior to use so we can see if their claims are substantiated or just another farce!

Also a log would be great!

[RU58841]

Almost certainly going to be trying this in 2-3 months. I got a call from them the other day saying I'll probably still have to visit Vancouver for the prescription but I'm willing to do that if it's the only way.

Specifically, what should I be asking for with the blood test? Just serum DHT levels? I'll be coming off oral finasteride, so should I try to be off that for a few weeks, get the blood test, then start the topical?

[TooMuchHairWontKillYou]

Hey,

I'm interested in topical fin. Is it already available? Where can I buy it? Price?

[mowingdown]

Almost certainly going to be trying this in 2-3 months. I got a call from them the other day saying I'll probably still have to visit Vancouver for the prescription but I'm willing to do that if it's the only way.

Specifically, what should I be asking for with the blood test? Just serum DHT levels? I'll be coming off oral finasteride, so should I try to be off that for a few weeks, get the blood test, then start the topical?

DHT is the big one of course, as that should tell us if H&W are telling the truth. Also if cost is an issue (which it sounds like it is not.), serum DHT would be the only one we really need to look at.

Otherwise testing Testosterone, FREE Testosterone, Estrogen, PSA, Prolactin, FSH, are all major ones if you are someone prone to side effects.

[mowingdown]

Check out Hasson & Wong's website with their new liposomal topical fin.

[TooMuchHairWontKillYou]

Check out Hasson & Wong's website with their new liposomal topical fin.

Thanks

I found this link

https://hassonandwong.com/topical-finasteride-solution-prescription/

But there is nothing about price and where to buy. Am I missing something?


aand... I know that there are some other topical fins (polichem?) Do you have any info on that? Which one is better?

[mowingdown]

Are you in the US? If so, you may have to wait. Or convince a European on these boards to buy and ship to you!

[cardib]

I'm already on topical fin from murray avenue apothecary. frankly i think they are all bullshit

[NeedHairASAP]

Fin can't work without going systematic.

https://en.wikipedia.org/wiki/Antiandrogen

you can alter the pathway by (1) stopping production of androgens or (2) blocking the receptors that receive androgens

aka

you can either (1) tackle the quarterback, or (2) you can try to intercept the ball from a wide receiver.

fin is for tackling the quarterback....it's for stopping the ball before it's been thrown (aka stopping the production of DHT before it goes into the blood stream). Which means intercepting the ball after it's been thrown is blocking the receptor from receiving androgens (or stopping the circulating DHT from acting on the receptors in your scalp).

You can't tackle the quarterback after he's thrown the ball. In other words, fin doesn't really do anything after the ball has been thrown (or the DHT has been produced and let into the bloodstream). Thus applying it locally is like thinking you can sack the QB after he threw the ball.

The only topicals that will work are ones that shut down the AR receptor. This is ideal because you can sill have high DHT (and not be a womanly man tit boy) and still stop the baldness.

if this topical fin is working (aka lowering circulating DHT), it's because it's gone systemic.

[stratowich]

Fin can't work without going systematic.

https://en.wikipedia.org/wiki/Antiandrogen

you can alter the pathway by (1) stopping production of androgens or (2) blocking the receptors that receive androgens

aka

you can either (1) tackle the quarterback, or (2) you can try to intercept the ball from a wide receiver.

fin is for tackling the quarterback....

It’s exactly these kinds of comments from uneducated morons like you who really make me don’t want to come back to these forums anymore. You are a disgrace to society man!

Just copy-pasting a wikipedia link without even then taking the time to further elucidate the point you are trying to make.

As you are obviously so educated on all of this, please explain to us the whole metabolic pathway of finasteride… The way liposomes pass the stratum corneum and locally release finasteride in the endoplasmic reticulum…

There is a very big chance this stuff Hasson & Wong is offering is not working, but there is all a decent chance this thing is a game changer for people who are prone or are afraid of systemic side-effects.

Using some fuc**** football analogy to prove your point - what a disgrace!!! Go read these papers and all references and all publications citing these and then come back and talk to all of us again:

... However, I still don't think this is all bulls**t they are planing on releasing. Dermal localized and prolonged drug-delivery systems have been around for a while now and are still subject of fundamental research. A brief glimpse into this field revealed the following:

http://onlinelibrary.wiley.com/doi/1...9.03100.x/full:
"... They also have the potential to target drugs into the pilosebaceous structures and hence they have an additional advantage for treatment of hair follicle-associated disorders. ... The similarity of lipid composition of liposomes and membranes in the epidermis enables the liposomes to penetrate into the epidermal barrier to a higher extent as compared with other application forms and so do the compounds encapsulated into the liposomes. This may result in an increased drug absorption into the epidermis and a decreased clearance of drug from the epidermis resulting in a much longer sustained drug release and reduction of drug absorption into the blood. This is why liposomes may act as drug transporters as well asdrug targeters.3 This may lead to increased effectiveness,reduction in side-effects and a higher compliance of patientsto treatment.3 Liposomes have also the potential to targetdrugs into the pilosebaceous structures and hence they canbe employed for treatment of hair follicle- and sebaceousgland-associated disorders.22–24"

http://www.sciencedirect.com/science...69409X07000403:
"Due to the lower risk of systemic side effects topical treatment of skin disease appears favourable, yet the stratum corneum counteracts the penetration of xenobiotics into viable skin. Particulate carrier systems may mean an option to improve dermal penetration. Since epidermal lipids are found in high amounts within the penetration barrier, lipid carriers attaching themselves to the skin surface and allowing lipid exchange between the outermost layers of the stratum corneum and the carrier appear promising."

Further reading:

http://www.sciencedirect.com/science/article/pii/0169409X95000194

http://www.ncbi.nlm.nih.gov/pubmed/19075893

http://www.jdsjournal.com/article/S0923-1811(96)00508-7/abstract

http://www.sciencedirect.com/science/article/pii/S0169409X0200114X

http://link.springer.com/article/10....105-003-0513-6

[nobs]

Fin can't work without going systematic.

https://en.wikipedia.org/wiki/Antiandrogen

you can alter the pathway by (1) stopping production of androgens or (2) blocking the receptors that receive androgens

aka

you can either (1) tackle the quarterback, or (2) you can try to intercept the ball from a wide receiver.

fin is for tackling the quarterback....it's for stopping the ball before it's been thrown (aka stopping the production of DHT before it goes into the blood stream). Which means intercepting the ball after it's been thrown is blocking the receptor from receiving androgens (or stopping the circulating DHT from acting on the receptors in your scalp).

You can't tackle the quarterback after he's thrown the ball. In other words, fin doesn't really do anything after the ball has been thrown (or the DHT has been produced and let into the bloodstream). Thus applying it locally is like thinking you can sack the QB after he threw the ball.

The only topicals that will work are ones that shut down the AR receptor. This is ideal because you can sill have high DHT (and not be a womanly man tit boy) and still stop the baldness.

if this topical fin is working (aka lowering circulating DHT), it's because it's gone systemic.

I'll try to be less harsh than stratowich. The argument you made would mean that topical minoxidil works by entering the bloodstream, which is not the case and why topical minoxidil can be found pretty much anywhere. To add to that, all the study participants on topical minoxidil had almost undetectable levels of the drug in their bloodstream. Finasteride is a very different drug than minoxidil from a chemical standpoint(lipophilic) and is easily absorbed through the bloodstream when applied with an ethanol carrier. I for one would be more than happy to do a before and after blood test while on Hasson and Wong's product. I live in the U.S. so I have to play the waiting game like the others unless a Canadian on here is willing to do it.

[PatientlyWaiting]

Will this be readily available in the US or reliable online pharmacies or it something I have to join some secret forum for and take chemistry 101 and buy a triple beam balance to make it myself? Is it a full finished product you just buy and use?

[nobs]

Will this be readily available in the US or reliable online pharmacies or it something I have to join some secret forum for and take chemistry 101 and buy a triple beam balance to make it myself? Is it a full finished product you just buy and use?

Finished product, already available in Canada but soon to be in United States within the next month or so. https://hassonandwong.com/topical-fi...-prescription/

[mowingdown]

It’s exactly these kinds of comments from uneducated morons like you who really make me don’t want to come back to these forums anymore. You are a disgrace to society man!

Just copy-pasting a wikipedia link without even then taking the time to further elucidate the point you are trying to make.

As you are obviously so educated on all of this, please explain to us the whole metabolic pathway of finasteride… The way liposomes pass the stratum corneum and locally release finasteride in the endoplasmic reticulum…

There is a very big chance this stuff Hasson & Wong is offering is not working, but there is all a decent chance this thing is a game changer for people who are prone or are afraid of systemic side-effects.

Using some fuc**** football analogy to prove your point - what a disgrace!!! Go read these papers and all references and all publications citing these and then come back and talk to all of us again:

Love the background you provided and sources Strat. You've really brought a lot of knowledge on this specific topic and it's helped me a great deal in understanding it.

I know it's a really frustrating topic and it's hard to constantly see misinformed people (even misinformed people who may possibly be correct), but try your best not to get too heated! We are all on the boards for the same reason and thus, in this together

[mowingdown]

I'm already on topical fin from murray avenue apothecary. frankly i think they are all bullshit

Is this the liposomal mixture? or just fin in topical form?