Dr Claire Higgins video ( new from three weeks ago)

[Renee]

https://m.youtube.com/watch?v=hNRanJ7FhtY

In the Q & A session (33:18) she mentions that somebody Is developing a roller where you can roll the dermal papilla cells onto your scalp. I could not clearly understand because of the recording, if somebody can understand what she is saying please explain

[Renee]

She says "people are developing rollers with spikes to be able to role dermal papilla on scalps."

Dr Higgins was part of christiano/jahoda team that cultured dermal papilla cells in 3d spheroids and when grafted onto human skin hair was induced.

Looks like she knows clearly some type of product is being developed, hopefully she is at the congress so we know more soon.

[hellouser]

AWESOME video. Everyone should watch this.

[nameless]

She says "people are developing rollers with spikes to be able to role dermal papilla on scalps."

Dr Higgins was part of christiano/jahoda team that cultured dermal papilla cells in 3d spheroids and when grafted onto human skin hair was induced.

Looks like she knows clearly some type of product is being developed, hopefully she is at the congress so we know more soon.

Will the dermal papilla have sufficient hair inductivity? I really doubt it.

[Swooping]

Just watched the presentation interesting, thanks. It's confirmed now also by several people that a hair follicle can regenerate.

[Swooping]

She says "people are developing rollers with spikes to be able to role dermal papilla on scalps."

Dr Higgins was part of christiano/jahoda team that cultured dermal papilla cells in 3d spheroids and when grafted onto human skin hair was induced.

Looks like she knows clearly some type of product is being developed, hopefully she is at the congress so we know more soon.

I find that to be interesting because if someone is thinking that far to develop a roller already, does that mean that someone has fixed the problem of culturing DP without losing signature expression and obtaining full inductivity or at least has come a far way with such obstacles?

How genius would that be a roller which would literally deliver DP between your dermis/epidermis and de-novo androgen insensitive hair follicles would start sprouting over your head.

[nameless]

I find that to be interesting because if someone is thinking that far to develop a roller already, does that mean that someone has fixed the problem of culturing DP without losing signature expression and obtaining full inductivity or at least has come a far way with such obstacles?

How genius would that be a roller which would literally deliver DP between your dermis/epidermis and de-novo androgen insensitive hair follicles would start sprouting over your head.

That would be very genius but I don't think they've figured out the inductivity problem for culturing DP cells.

[baldybald]

Is this the same as cotsarales technique and wounding stuff or something else ?

[hellouser]

Is this the same as cotsarales technique and wounding stuff or something else ?

Completely different.

[Swooping]

Is this the same as cotsarales technique and wounding stuff or something else ?

The roller stuff she talks about? No that wouldn't be wounding. The hair follicle consists of many types of cells. One of them at the base of the hair follicle are called "dermal papilla cells". Incredibly important cells for the hair follicle.

In 2013 Higgins (the lady in the presentation) released a paper together with some top elite hair loss researchers where they cultured these dermal papilla cells (to grow them, multiply them). However there is a problem with culturing dermal papilla cells. When you multiple these cells in culture they begin to lose their "characteristics". So when you would initially start from fresh dermal papilla cells taken from your hair follicle and you culture them they will be different and lose their signature. So in that paper they explain that they could partially restore the dermal papilla signature when cultured in a high-tech method. They even did transplant these dermal papilla cells onto human skin and it did induce a hair follicle. However because they weren't able to fully restore the signature the hair follicle was retarded. Not like you would expect to see a normal hair follicle.

So she talks about a roller with dermal papilla cells on them. In theory when someone would fix the problems with culturing dermal papilla cells they could take a hair follicle from the back of your head. After that dissect your hair follicle, take the dermal papilla cells and grow them in culture in a lab. Then they could probably with some sort of roller deliver them to your skin and these cells would instruct to make a whole hair follicle. Leaving you with a full head of hair with androgen insensitive hair follicles pretty much. All theory off course, but nonetheless interesting that she is going as far as mentioning a "roller".

[joachim]

can't we just concact her to ask about that roller she mentioned?
is anybody in touch with her via email or so?

[Killmenow]

can't we just concact her to ask about that roller she mentioned?
is anybody in touch with her via email or so?

Here is her email if anyone wants to try and get more info.....:

c.higgins@imperial.ac.uk

[baldybald]

The roller stuff she talks about? No that wouldn't be wounding. The hair follicle consists of many types of cells. One of them at the base of the hair follicle are called "dermal papilla cells". Incredibly important cells for the hair follicle.
In 2013 Higgins (the lady in the presentation) released a paper together with some top elite hair loss researchers where they cultured these dermal papilla cells (to grow them, multiply them). However there is a problem with culturing dermal papilla cells. When you multiple these cells in culture they begin to lose their "characteristics". So when you would initially start from fresh dermal papilla cells taken from your hair follicle and you culture them they will be different and lose their signature. So in that paper they explain that they could partially restore the dermal papilla signature when cultured in a high-tech method. They even did transplant these dermal papilla cells onto human skin and it did induce a hair follicle. However because they weren't able to fully restore the signature the hair follicle was retarded. Not like you would expect to see a normal hair follicle.

So she talks about a roller with dermal papilla cells on them. In theory when someone would fix the problems with culturing dermal papilla cells they could take a hair follicle from the back of your head. After that dissect your hair follicle, take the dermal papilla cells and grow them in culture in a lab. Then they could probably with some sort of roller deliver them to your skin and these cells would instruct to make a whole hair follicle. Leaving you with a full head of hair with androgen insensitive hair follicles pretty much. All theory off course, but nonetheless interesting that she is going as far as mentioning a "roller".

That's a very good explanation. I wonder if she is in trouble mentioning about the roller and giving too much info.

[Keeper]

Ask her !

[ShookOnes]

Can't wait until this is viable in 15 years!