Pax1/Foxa2- 1 of the primary genetic reasons why we balding men- are balding

[eldarlmario]

voiding my question? Are you not a 'layman'?

lol dude- I dont think im 1 here and I DONT have to proof anything to you.

this all sounds interesting, but complicated as hell.
pleas could you sum ALL FINDINGS IN ONE POST?
A sort of a "how-to" guide for us not-so-experienced here.

thank you

the first page is all u need to look for the small molecule experimentals.

[eldarlmario]

Simple terms(Dr Cotasarelis's findings):

Magic formula = Cd34 + CD200 +Cd49F

= hair growth

CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5%
CD200: topical Calcitirol or Calcipotriol(generic creams are available at 0.005%)
CD49f: topical Tretinoin (generic creams/gels are available at 0.01%)

+ 1.5mm once/mth soft dermarolling

= hair growth

U need to stop DHT(higher potency) and Testerone first from exerting their acitions on further expanding your balding skull and inhibiting hair growth in AGA individuals. SO- it's:

1)CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5%
2)CD200: topical Calcitirol or Calcipotriol(generic creams are available at 0.005%)
3)CD49f: topical Tretinoin (generic creams/gels are available at 0.01%)

AND

4)An androgen receptor blocker like RU58841 or Valproic acid, etc.

5)+ 1.5mm transient soft dermarolling(optional)

= hair growth

[eldarlmario]

Simple terms(Dr Cotasarelis's findings):

Magic formula = Cd34 + CD200 +Cd49F

= hair growth

CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5%
CD200: topical Calcitirol or Calcipotriol(generic creams are available at 0.005%)
CD49f: topical Tretinoin (generic creams/gels are available at 0.01%)

+ 1.5mm once/mth soft dermarolling

= hair growth

U need to stop DHT(higher potency) and Testerone first from exerting their acitions on further expanding your balding skull and inhibiting hair growth in AGA individuals. SO- it's:

1)CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5%
2)CD200: topical Calcitirol or Calcipotriol(generic creams are available at 0.005%)
3)CD49f: topical Tretinoin (generic creams/gels are available at 0.01%)

AND

4)An androgen receptor blocker like RU58841 or Valproic acid, etc.

5)+ 1.5mm transient soft dermarolling(optional)

= hair growth

adding those stated below would be an added bonus:

6)Crth2 inhibitor- stops TH2 cytokines from attacking follicles.
7)Dutasteride- stops DHt. i dont think i have to explain this.
8)Curcumin- Gsk3B inhibitor. activates SERPINA1(upregulated 5.721 folds in haired scalp) which in turn- inhibits CORIN(most downregulated gene in haired-scalp)
9)Cilnodipine- calcium channel blocker. decreases intracellular calcium levels- thereby widening blood vessels(vasodilation)

I hope this is simple enough. please google on the drugs effect and for their relationship with hair(e.g Cilnodipine is a calcium channel blocker- so google *calcium channel blockers hair*) IF you are keen to find out, Curcumin is a GSK3B inhibitor- google *Gsk3B Hair*, etc etc )

[Hairismylife]

Seti is a crth2 inhibitor?

[eldarlmario]

Seti is a crth2 inhibitor?

Yes it is.

[hellouser]

Simple terms(Dr Cotasarelis's findings):

Magic formula = Cd34 + CD200 +Cd49F

= hair growth

CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5%
CD200: topical Calcitirol or Calcipotriol(generic creams are available at 0.005%)
CD49f: topical Tretinoin (generic creams/gels are available at 0.01%)

+ 1.5mm once/mth soft dermarolling

= hair growth

U need to stop DHT(higher potency) and Testerone first from exerting their acitions on further expanding your balding skull and inhibiting hair growth in AGA individuals. SO- it's:

1)CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5%
2)CD200: topical Calcitirol or Calcipotriol(generic creams are available at 0.005%)
3)CD49f: topical Tretinoin (generic creams/gels are available at 0.01%)

AND

4)An androgen receptor blocker like RU58841 or Valproic acid, etc.

5)+ 1.5mm transient soft dermarolling(optional)

= hair growth

Lithium Chloride for CD200 expression.

You forgot that you need to inhibit PGD2, so setipiprant is necessary.

[eldarlmario]

ok here it goes again- all in 1 single post:

you will need the following:

1)CD34: topical PGE2 or topical Valproic acid(generic PGE2 gels is availble at 0.5%- nothing higher than that)
2)CD200: topical Calcitirol or Calcipotriol(generic creams are available at 0.005%- nothing higher than that)
3)CD49f: topical Tretinoin (generic creams/gels are available at 0.01%- nothing higher than that)
4)An Androgen Receptor blocker(preferably topical) like RU58841 or Valproic acid, etc. Stops further hair growth-inhibiting androgenic actions in AGA scalps.

to provide the basics to regrow hair

AND

5)optional 1.5mm once/mth soft dermarolling protocol(Just do till the scalp turns slightly red. It is absolutely unnecessary to whip things up into a bloody mess- literally).

WITH the following as an added bonus to achieve optimal results:

6)oral/topical Crth2 inhibitor- Stops TH2 cytokines from attacking hair follicles in the balding scalp. The name of the receptor already tells us it's function- 'Chemokine Receptor Expressed On T-Cell Helper 2'.
7)oral/topical Dutasteride- Decreases DHT(Steroid with higher potency to inhibit hair growth in AGA scalp)- but increases free Testerone levels(Steroid with much lower potency to inhibit hair growth in AGA scalps). i dont think i have to explain this.
8)topical Curcumin- GSK3B inhibitor. Activates SERPINA1(upregulated 5.721 folds in haired scalp) which in turn- inhibits CORIN(most downregulated gene in haired-scalp).
9)topical Cilnodipine- Calcium channel blocker. Decreases intracellular calcium levels(High levels of it leads to pathologies like fibrosis, soft tissue mineralization, etc)- thereby widening blood vessels(vasodilation) in the balding scalp.

AND IF you want to further add in something to guarantee at least some hair growth- our good ol' 10)topical/oral Minoxidil(preferbably sulfated- its active metabolite) is the prime candidate.

9 experimental components for a full regime(10 if you add in Minoxidil sulfate as a proven chemical for regrowing hair)

[Hairismylife]

Eldar your help is very much appreciated.
I have faith in your golden formula but could you please suggest me a place to buy calcitirol/calcipotriol and tretinoin? Thanks in advance.

[eldarlmario]

Eldar your help is very much appreciated.
I have faith in your golden formula but could you please suggest me a place to buy calcitirol/calcipotriol and tretinoin? Thanks in advance.

Source B in Post 90 of this thread

[walrus]

lol dude- I dont think im 1 here and I DONT have to proof anything to you.

Considering your claim of making insightful observations from the literature, it is entirely reasonable to ask what exactly makes you qualified. Especially given your outlandish claims about Scoliosis. The best you could muster was 'trust me I am'. Bro-science at its finest.

the first page is all u need to look for the small molecule experimentals.

Or alternatively, people can view the primary literature for themselves without your added quack commentary: https://scholar.google.co.uk/scholar...ia%22&scisbd=1

[eldarlmario]

Considering your claim of making insightful observations from the literature, it is entirely reasonable to ask what exactly makes you qualified. Especially given your outlandish claims about Scoliosis. The best you could muster was 'trust me I am'. Bro-science at its finest.



Or alternatively, people can view the primary literature for themselves without your added quack commentary: https://scholar.google.co.uk/scholar...ia%22&scisbd=1

Exactly and that leads back to my very first response to you, Mr Egoist. The second quote was an repeated error that was intended to be included in the post below it- and even then- just look how you have went into details towards responding to it. Shows alot of your intention in this thread. U can always leave this thread if you find the information here 'insightful'. no1's stopping you. lol

[Hairismylife]

Source B in Post 90 of this thread

Also selling lithium chloride?

[eldarlmario]

Also selling lithium chloride?

Source A or Source D

[eldarlmario]

Also selling lithium chloride?

Source A or Source D

[eldarlmario]

.