Pax1/Foxa2- 1 of the primary genetic reasons why we balding men- are balding

[eldarlmario]

In what concentration would you consider using oral setipiprant then? I have not found any data about bioavailability other than 50% being uselessly metabolized in the stomach. Is an affordable amount of mass even sufficient to make it to the follicle to inhibit CRTH2?

'then'? that's what i would like to know too

[bibi]

Thank you eldarlmario for all these information.
I'm taking Montelukast for my asthma since 2 weeks and I've noticed a less itchy scalp during the past week.. I don't know if it's due to Montelukast or not, but can you tell me more precisly how it would work against mpb?
Thank you again

[eldarlmario]

Thank you eldarlmario for all these information.
I'm taking Montelukast for my asthma since 2 weeks and I've noticed a less itchy scalp during the past week.. I don't know if it's due to Montelukast or not, but can you tell me more precisly how it would work against mpb?
Thank you again

Montelukast and any other Leukotriene antagonists works by inhibiting IL-4(hence- blocking the differentiation of all TH2 cytokines) and blocking PGD2 and PGE2 synthesis. The CRTh2(Chemokine Receptor expressed on T Cell Helper 2) receptor is thus render incapable of attracting any TH2 cytokines from chemotaxing to where it's expressed in(like the mast cells in the hair) because there is none to begin with. You are going to need supplementing PGE2 to compensate for the loss of PGE2 production but then again- PGE2 production is already unexpressed(in fact- it's inversely expressed) in balding scalp.

So an comparison on the difference between a Leukotriene antagonist and a CRTh2 ihnbiitor:

CRTH2 inhibitor(TM/Seto/Rama/OC): blocks the receptor attracting TH2 cytokines to where it's expressed in by a homing mechanism called Chemotaxis. It can be expressed in any tissue in the body where PGD2 is expressed in.
Leukotriene antagonists: blocks the synthesis of TH2 cytokines in the first place by inhibiting production of IL-4(the 'master cytokine' of TH2 cytokines. Any production of other TH2 cytokines requires the upregulation of IL4 first)

[Hairismylife]

Eldarlmario in your opinion if I use Calci+pge2 only, can I expect some regrowth?

The Calci is so powerful that tackles so many genes?

What dosage to use per day?

Thanks

[bibi]

Thank you for your answer Eldarlmario.
As english is not my native langage, It was diffucult for me to undestand 100% of these 19 pages of information.
Could you please briefly tell me the relation of TH2 with PGD2 and so AGA.
Thank you my friend.

[eldarlmario]

Eldarlmario in your opinion if I use Calci+pge2 only, can I expect some regrowth?

The Calci is so powerful that tackles so many genes?

What dosage to use per day?

Thanks

U're gonna need 3 things + 1 more to even try and archive regrowth:

1)CD34 upregulator <== oral or topical PGE2 OR topical Valproic acid
2)CD200 upregulator<== topical Calcipotriol/Calcitriol
3)CD49F upregulator<== topical Tretinoin

+

4)Androgen Receptor inhibitor<== topical Valproic acid OR topical RU58841 OR any of the mainstream AR inhibitors(Spiro, etc)

just use the premade strength of 0.005% for topical Calcipotriol.

[eldarlmario]

Thank you for your answer Eldarlmario.
As english is not my native langage, It was diffucult for me to undestand 100% of these 19 pages of information.
Could you please briefly tell me the relation of TH2 with PGD2 and so AGA.
Thank you my friend.

*Lazy poster alert*

[Hairismylife]

U're gonna need 3 things + 1 more to even try and archive regrowth:

1)CD34 upregulator <== oral or topical PGE2 OR topical Valproic acid
2)CD200 upregulator<== topical Calcipotriol/Calcitriol
3)CD49F upregulator<== topical Tretinoin

+

4)Androgen Receptor inhibitor<== topical Valproic acid OR topical RU58841 OR any of the mainstream AR inhibitors(Spiro, etc)

just use the premade strength of 0.005% for topical Calcipotriol.

CB as AR inhibitor ok?

And 0.005% means how many mg in 1ml?

[eldarlmario]

CB as AR inhibitor ok?

And 0.005% means how many mg in 1ml?

50mcg. yes CB is ok

[Hairismylife]

50mcg. yes CB is ok

Calcipo safe to use?
Any systematic or sex or any other else possible sides?

And tretinoin?

Thank in advance. I'm ready to order some.

[eldarlmario]

Calcipo safe to use?
Any systematic or sex or any other else possible sides?

And tretinoin?

Thank in advance. I'm ready to order some.

Calcipotriol:

Medical uses[edit]
Chronic plaque psoriasis is the chief medical use of calcipotriol.[1] It has also been used successfully in the treatment of alopecia areata.[2]
Adverse effects[edit]
Adverse effects by frequency:[1][3][4][5]
Very common (> 10% frequency)
Burning
Itchiness
Skin irritation
Common (1–10% frequency)
Dermatitis
Dry skin
Erythema
Peeling
Worsening of psoriasis including facial/scalp
Rash
Uncommon (0.1–1% frequency)
Exacerbation of psoriasis
Rare (< 0.1% frequency)
Allergic contact dermatitis
Hypercalcaemia
Photosensitivity
Changes in pigmentation
Skin atrophy



Tretinoin:

Side effects[edit]
In dermatological use[edit]

This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2011)
When used, dryness or increased sensitivity to sunlight of the affected skin may occur.[13] More sensitive patients may also experience redness, scaling, itching, and burning.[14] A gradual increase in the frequency and amount of tretinoin application is best, as this allows one's skin to adequately adjust to the drug. Patients should be careful to follow their physician's recommendations when beginning a round of treatment.
As this product may cause irritation, it may indirectly increase sun sensitivity and fragility of the skin.[15] Patients who are using the drug should apply moisturizer and sunscreen to reduce the chance of developing sunburn while using tretinoin.[15] Additionally, patients using tretinoin should be cautious when simultaneously using other topical medications that contain salicylic acid, resorcinol, or sulfur because these medications may potentiate the drying and possibly irritating effects of tretinoin.[16] Topical tretinoin should be avoided during pregnancy because its use has been linked to birth defects in several case reports.[17]

[bibi]

*Lazy poster alert*

Oh please..
Or just tell me the page important I will try to translate it.
Thank you.

[Hairismylife]

Thanks Eldarl.
But tbh you have no sucess in regrowth, what's missing in your longlong regime!

[eldarlmario]

Thanks Eldarl.
But tbh you have no sucess in regrowth, what's missing in your longlong regime!

is this considered regrowth?

[IMG][/IMG]

[IMG][/IMG]

[awdtnr91]

is this considered regrowth?

[IMG][/IMG]

[IMG][/IMG]

Woahh....

After reading through all of this and seeing results could we obtain a quick outline. I understand you have expressed everything needed above. But for those of us who haven't been in the hair game too long, something to simplify the process. Buy these things, mix them with this, and to this daily... to acheive such results? It would be greatly appreciated.