Approved drug that could save our dermal papilla cells! 'Troxerutin'

[noisette]

I found a product with Troxerutin for hair loss. Use this product with a dermaroller.

source : http://www.laser-ipl-brighton.co.uk/hair-table.html

"Hair ****tail Plus

Product
Toskani's specially designed composition for hair loss treatment combined with the knowledge and experience of Mesotherapy practitioners provides the ultimate formula for hair loss treatment.

Indications

Clean the surface to be treated
Divide the zone in small sub-areas
Apply the derma roller in different directions (vertical, horizontal and transverse) while dripping on the surface
Repeat the same steps in other sub-areas

Composition

Dexpanthenol
Taurine
Glutathion
Biotine
Fe-Gluconat
Thiamine
Troxerutine
Sabal serrulata (anti-androgenous action)
"

[noisette]

Hey seuxin t'es Français du coup?
c'est pas fait pour la perte de cheveux a la base, c'est un medicament deja sur le marché depuis des années, mais l'etude que j'ai posté date de ya 2 mois, et ils disent que ca serait une approche efficace pour lutter contre la chute de cheveux
donc oui c'est deja dans nos pharmacies, j'ai chercher en France ils vendent troxerutin en poudre, 3500g dans 10 sachets, a melanger dans l'eau
le probleme c'est qu'on sait pas a quel dose en prendre, j'hesite entre 50/100mg par jour ou 400/500

Hey Lacazette
I found this, on a gel form... Perhaps we can test it directly on hairs.

http://www.homeapteka.com/productdetail.asp?productid=6518

[Furious]

Can you use this? http://www.ebay.com/itm/TROXERUTIN-t...tem3aadaa7cec#

[lacazette]

Hey seuxin t'es Français du coup?
c'est pas fait pour la perte de cheveux a la base, c'est un medicament deja sur le marché depuis des années, mais l'etude que j'ai posté date de ya 2 mois, et ils disent que ca serait une approche efficace pour lutter contre la chute de cheveux
donc oui c'est deja dans nos pharmacies, j'ai chercher en France ils vendent troxerutin en poudre, 3500g dans 10 sachets, a melanger dans l'eau
le probleme c'est qu'on sait pas a quel dose en prendre, j'hesite entre 50/100mg par jour ou 400/500

[Seuxin]

I'm in france too, but, what is this product ? It's already out ? Troxerutin ?

[lacazette]

Any1 have place where can get this ?

I would like to try...

Hey man, I think you talk about legal pharma online websites,but sorry I personnaly don't know any as I never did it, others here will help you

But in France it's without prescription, so i will give it a try and buying it directly in a pharma store. I think it's without prescription in most of the countries, you could do the same, unless you prefer command on the net

[VegetaDBZ]

Any1 have place where can get this ?

I would like to try...

[Not giving up]

Yes <Dench it sounds to me like at least a good addon that won't hurt us, and that could slightly help with other treatments.
All the trial of this drug I saw is short term use, just a few ones ( with like 10 people or 50 people ) were more than 6months, etc.. and a lot were woman, as it is an effective drug for post pregnancy few problems. So there's maybe not too much balding man who tried it in a right long term use to see if there's improvment .
Hair cycling,etc take time, so even if one has had little improvment, with that few months , it couldn't be a visually difference for him to see it, and couldn't link that with the drug, and even the researchers didn't look their scalp as there were no link between hair, the clinical trials were designed for vascular, hemorroids,etc for the quasi majority in short term use (10 days/1month) and a few ones with long term use but with few participants and more women.

so that gives me little hope that with the right dosage for oral long term, or in topical aplication on a good gel, it could gives good results (at least help to reduce a little little bit the unstopable hair loss process^^ in combination with actual treatments of cpurse)

All sounds good to me! Do you think it would reduce or halt shedding?

[lacazette]

Yes <Dench it sounds to me like at least a good addon that won't hurt us, and that could slightly help with other treatments.
All the trial of this drug I saw is short term use, just a few ones ( with like 10 people or 50 people ) were more than 6months, etc.. and a lot were woman, as it is an effective drug for post pregnancy few problems. So there's maybe not too much balding man who tried it in a right long term use to see if there's improvment .
Hair cycling,etc take time, so even if one has had little improvment, with that few months , it couldn't be a visually difference for him to see it, and couldn't link that with the drug, and even the researchers didn't look their scalp as there were no link between hair, the clinical trials were designed for vascular, hemorroids,etc for the quasi majority in short term use (10 days/1month) and a few ones with long term use but with few participants and more women.

so that gives me little hope that with the right dosage for oral long term, or in topical aplication on a good gel, it could gives good results (at least help to reduce a little little bit the unstopable hair loss process^^ in combination with actual treatments of cpurse)

[Dench57]

Check this out:

http://www.merck-performance-materials.com/en/cosmetics/ronacare/ronacare_troxerutin/ronacare_troxerutin.html

This skincare ingredient using troxerutin is produced by - you guessed it - Merck (Propecia). Surely they would know if it had hair benefits?

Interesting attributes this drug has though...

"One of the most stable bioflavonoids, troxerutin, is known to inhibit lipoxygenase, an enzyme responsible for inflammation and allergic conditions. And RonaCare® Troxerutin dramatically inhibits the formation of prostaglandins, the well-known inflammation mediators.

In addition to its anti-inflammatory features, RonaCare® Troxerutin can improve insufficient microcirculation"

To the layman (me) these looks like nice properties in relation to MPB?
1. Inhibition of prostaglandins - implicated in hair loss, however does it inhibit the good PGE2 or the bad PGD2?
2. Reduces enzymes responsible for inflammation. Can't be a bad thing.
3. Increased micro-circulation/blood flow. Also can't be a bad thing for hair loss as far as I'm aware.

Waiting for someone more knowledgeable to come and shoot all this down.

[Dench57]

Interesting find, nice one. Encouraging that the study only came out 2 months ago...could be a genuinely new insight.

I have no idea about the science behind this though, and how significant the role of 'reactive oxygen species' is in hair tissue and dermal papilla cells in MPB sufferers. Hopefully one of the more knowledgeable guys on this board can tell us more?

However the sceptic in me thinks if this drug has been used to treat varicose veins, haemorrhoids etc since the 1960s, you would really think someone would've realised it's hair saving/growing benefits in that time. Definitely seems worth a try though!

[Not giving up]

Dude, if you can figure out a dose for this I'm all over it. I'd rather take an oral and forget about it all day than a messy annoying topical!

[lacazette]

Hey Jay yes I think it could be good with a gel like follicept to directly deliver around the follicles

Ive just search in my country France, the drug is sold without prescription, 3500mg in ten single dose packets. Powder that you put in water and drink, so easy use

Really tempted to give it a try, but still wondering if I should take 50/100mg a day or 400/500 mg a day

Ive seen clinical trial studies with patients take more than 600mg a day during a year, with no adverse effects so it seems to be safe (and even trial with high dose 5G/day for 2 months without side effect execpt gastro problems for a few of them)

[JayM]

I would maybe take orally and topically? Because then you will be getting it right to the follicles plus orally you might get more and added health Benefits?

Also for delivery there are a lot of people here who know how to make the best kind of gel.

Maybe way out there but email follicept and ask if you could use their gel? In all likelihood a no but asking never hurt anyone haha. At least something could come out of it.

[lacazette]

I've just search and found oral Troxerutin 5G for 60 euros. In the normal treatment for Chronic venous insufficiency, they tell to take for an adult 600-1200 MG per day. so maybe we could take less than that but still have benefits on our DP cells. Let's say if I take 200mg , it will last me 25 days. Or 100mg/50days. So if it has REAL benefits, it's not that expensive

There's also gel for topical application that is not expansive, but if I follow the study I think, but im not certain, it would work better with oral treatment

"It helps to stabilize cell walls, making them less permeable, so that fluids are passed between cells and blood cells at normal levels. The medication also affects the quality of the capillaries that supply oxygen to these cells by making them stronger and less brittle. The walls of the veins in the affected area also become more stable, so that platelets do not stick to them and fluids are able to pass freely through them"