Hasson & Wong Update on Topical Finasteride

[efedrez]

Hey guys, I just came on to write about Topical Finasteride and came across this thread.

We have actually came up with a decent formula to make Finasteride topical foaming solution. Our pharmacy is making the first batch this week for 2 patients.

I can't send it overseas to anyone but I can do 2 things:
a) if you are in Australia, let me know if you'd like some and I can make it for you. We just need a prescription from an Australian prescriber.

b) if the guys overseas, the best I can do is provide everyone with the formula and ingredients necessary and you can make it yourself. Albeit it may be a tad bit didficult.

I'll keep an eye on this thread. Let me know

Cheers.

Desmond

Hello Desmond, great to gear you are working on this as well.

Do you have any indications to believe your formulation wont got systemic? are you planning to drop oral fin yourself and jump into topical?

Thanks

[FearTheLoss]

topcal finasteride will always have sides. There is no happy-medium where you can get the treatment to work, without sides. The dose response curve for finasteride is steep, so .1mg reduced DHT by about the same as a whole 1mg.


There's no way to do this. Sorry to disappoint you guys. We need to focus on getting CB, Seti and advancing information surrounding PRP.

[RU58841]

topcal finasteride will always have sides. There is no happy-medium where you can get the treatment to work, without sides. The dose response curve for finasteride is steep, so .1mg reduced DHT by about the same as a whole 1mg.


There's no way to do this. Sorry to disappoint you guys. We need to focus on getting CB, Seti and advancing information surrounding PRP.

You say it does, Hasson & Wong says it doesn't. Somebody's gotta be wrong. No need to apologize: I'll wait to be disappointed after I try it myself and see that it doesn't work. Besides, I'd prefer a topical to a pill anyway.

[FearTheLoss]

You say it does, Hasson & Wong says it doesn't. Somebody's gotta be wrong. No need to apologize: I'll wait to be disappointed after I try it myself and see that it doesn't work. Besides, I'd prefer a topical to a pill anyway.

I say it does, science says it does..HW is the only one against that. The people who don't have sides topically are the ones who's sides were placebo. Simple as that

[RU58841]

If you have the scientific study that showed that topical finasteride was effective and also responsible for the same side effects as the oral version, all you had to do was post the link.

[bigentries]

Would this count? http://www.nature.com/jid/journal/v1.../5610726a.html

Also search "Topical 0.05% finasteride significantly reduced serum DHT concentration" I can't link the study but people have posted it in other forums

I've always felt it's extremely unethical to push topical finasteride without reassurance that it will not go systemic

Systemic absorption is the only reason someone might choose topical vs oral administration. What's the point of using a topical if you get the same results (and sides) that you get from a pill?

[Swooping]

Topical finasteride will and needs to go systemic to be effective. It's that simple. There is no other way around that fact. The pharmacokinetics of finasteride are not suitable to not go systemic by topical application.

[It's2014ComeOnAlready]

Topical finasteride will and needs to go systemic to be effective. It's that simple. There is no other way around that fact. The pharmacokinetics of finasteride are not suitable to not go systemic by topical application.

Well, what's interesting is that St. John's Wort is known to reduce plasma levels of finasteride. If it's effectively used topically, and taken with St. John's Wort, you could probably reduce or eliminate side effects of this drug running through your system, while keeping the effectiveness on your scalp.

[RU58841]

Topical finasteride will and needs to go systemic to be effective. It's that simple. There is no other way around that fact. The pharmacokinetics of finasteride are not suitable to not go systemic by topical application.

I realize that, as it inhibits production of DHT, but the issue isn't a question of "how do we make finasteride effective?" it's "why do some people get side effects when others don't?"

The answer can't simply be that reduction of DHT directly causes these side effects, or else everyone would experience them, and there wouldn't be people reporting side effects on finasteride but no side effects on dutasteride. There is apparently something more to it.

[KO1]

Would this count? http://www.nature.com/jid/journal/v1.../5610726a.html

Also search "Topical 0.05% finasteride significantly reduced serum DHT concentration" I can't link the study but people have posted it in other forums

I've always felt it's extremely unethical to push topical finasteride without reassurance that it will not go systemic

Systemic absorption is the only reason someone might choose topical vs oral administration. What's the point of using a topical if you get the same results (and sides) that you get from a pill?

Serum DHT concentration is NOT the same thing as serum finasteride concentration. Finasteride can stay local and still reduce serum DHT.

[KO1]

Topical finasteride will and needs to go systemic to be effective.

Why do you say it needs to go systemic to be effective? 5AR2 is present in the scalp, so if it knocks it out locally, I don't see why we would need systemic presence of fin for it to be effective?

[Swooping]

Why do you say it needs to go systemic to be effective? 5AR2 is present in the scalp, so if it knocks it out locally, I don't see why we would need systemic presence of fin for it to be effective?

Well let me re-phrase that. It will surely be a whole lot less effective if it only stays local (it doesn't though). Let's assume you knockout all 5AR2 on the scalp you still have much DHT coming through the blood which can bind to the AR in the dermal papilla. So ideally you want to block systemic 5ar2 not only local 5ar2.

[KO1]

That's the thing though, *my understanding* is that DHT is something that is locally active in the target tissue, while the DHT that is floating around is spillover from the target tissue and in smaller amounts. If that is true then I don't think we would need systemic presence of fin.

[FearTheLoss]

You don't need systemic presence of fin, however, you can't stop it from doing so. Even if a little amount enters the blood stream, the dose-response curve is such that it will cause side effects. That's why things like CB work, without sides.

[Swooping]

That's the thing though, *my understanding* is that DHT is something that is locally active in the target tissue, while the DHT that is floating around is spillover from the target tissue and in smaller amounts. If that is true then I don't think we would need systemic presence of fin.

5AR2 is located in many tissues and so is DHT is produced in many tissue. The 5AR2 located on the scalp is only a fraction of the 5AR2 that is located somewhere else in tissue.

This would still leave much of DHT that is located in the blood serum to bind to the dermal papilla.

It would probably be effective but far less when it's going systemic, which it is going to do anyway.