Hasson & Wong Update on Topical Finasteride

[KO1]

Would this count? http://www.nature.com/jid/journal/v1.../5610726a.html

Also search "Topical 0.05% finasteride significantly reduced serum DHT concentration" I can't link the study but people have posted it in other forums

I've always felt it's extremely unethical to push topical finasteride without reassurance that it will not go systemic

Systemic absorption is the only reason someone might choose topical vs oral administration. What's the point of using a topical if you get the same results (and sides) that you get from a pill?

Serum DHT concentration is NOT the same thing as serum finasteride concentration. Finasteride can stay local and still reduce serum DHT.

[RU58841]

Topical finasteride will and needs to go systemic to be effective. It's that simple. There is no other way around that fact. The pharmacokinetics of finasteride are not suitable to not go systemic by topical application.

I realize that, as it inhibits production of DHT, but the issue isn't a question of "how do we make finasteride effective?" it's "why do some people get side effects when others don't?"

The answer can't simply be that reduction of DHT directly causes these side effects, or else everyone would experience them, and there wouldn't be people reporting side effects on finasteride but no side effects on dutasteride. There is apparently something more to it.

[It's2014ComeOnAlready]

Topical finasteride will and needs to go systemic to be effective. It's that simple. There is no other way around that fact. The pharmacokinetics of finasteride are not suitable to not go systemic by topical application.

Well, what's interesting is that St. John's Wort is known to reduce plasma levels of finasteride. If it's effectively used topically, and taken with St. John's Wort, you could probably reduce or eliminate side effects of this drug running through your system, while keeping the effectiveness on your scalp.

[Swooping]

Topical finasteride will and needs to go systemic to be effective. It's that simple. There is no other way around that fact. The pharmacokinetics of finasteride are not suitable to not go systemic by topical application.

[bigentries]

Would this count? http://www.nature.com/jid/journal/v1.../5610726a.html

Also search "Topical 0.05% finasteride significantly reduced serum DHT concentration" I can't link the study but people have posted it in other forums

I've always felt it's extremely unethical to push topical finasteride without reassurance that it will not go systemic

Systemic absorption is the only reason someone might choose topical vs oral administration. What's the point of using a topical if you get the same results (and sides) that you get from a pill?

[RU58841]

If you have the scientific study that showed that topical finasteride was effective and also responsible for the same side effects as the oral version, all you had to do was post the link.

[FearTheLoss]

You say it does, Hasson & Wong says it doesn't. Somebody's gotta be wrong. No need to apologize: I'll wait to be disappointed after I try it myself and see that it doesn't work. Besides, I'd prefer a topical to a pill anyway.

I say it does, science says it does..HW is the only one against that. The people who don't have sides topically are the ones who's sides were placebo. Simple as that

[RU58841]

topcal finasteride will always have sides. There is no happy-medium where you can get the treatment to work, without sides. The dose response curve for finasteride is steep, so .1mg reduced DHT by about the same as a whole 1mg.


There's no way to do this. Sorry to disappoint you guys. We need to focus on getting CB, Seti and advancing information surrounding PRP.

You say it does, Hasson & Wong says it doesn't. Somebody's gotta be wrong. No need to apologize: I'll wait to be disappointed after I try it myself and see that it doesn't work. Besides, I'd prefer a topical to a pill anyway.

[FearTheLoss]

topcal finasteride will always have sides. There is no happy-medium where you can get the treatment to work, without sides. The dose response curve for finasteride is steep, so .1mg reduced DHT by about the same as a whole 1mg.


There's no way to do this. Sorry to disappoint you guys. We need to focus on getting CB, Seti and advancing information surrounding PRP.

[efedrez]

Hey guys, I just came on to write about Topical Finasteride and came across this thread.

We have actually came up with a decent formula to make Finasteride topical foaming solution. Our pharmacy is making the first batch this week for 2 patients.

I can't send it overseas to anyone but I can do 2 things:
a) if you are in Australia, let me know if you'd like some and I can make it for you. We just need a prescription from an Australian prescriber.

b) if the guys overseas, the best I can do is provide everyone with the formula and ingredients necessary and you can make it yourself. Albeit it may be a tad bit didficult.

I'll keep an eye on this thread. Let me know

Cheers.

Desmond

Hello Desmond, great to gear you are working on this as well.

Do you have any indications to believe your formulation wont got systemic? are you planning to drop oral fin yourself and jump into topical?

Thanks

[Seuxin]

Hey guys, I just came on to write about Topical Finasteride and came across this thread.

We have actually came up with a decent formula to make Finasteride topical foaming solution. Our pharmacy is making the first batch this week for 2 patients.

I can't send it overseas to anyone but I can do 2 things:
a) if you are in Australia, let me know if you'd like some and I can make it for you. We just need a prescription from an Australian prescriber.

b) if the guys overseas, the best I can do is provide everyone with the formula and ingredients necessary and you can make it yourself. Albeit it may be a tad bit didficult.

I'll keep an eye on this thread. Let me know

Cheers.

Desmond

Good to hear that Desmond,


What vehicle do you use ? Versapro ? A liposomal gel ? A liquide ?
What will be the dosage ? I know Hasson and wong is a gel @ 2.5%

Do you think we could male our own finasterid topical with fina as powder and versapro or another liposomal cream ?

Thanks

[stratowich]

Just noticed that the second link isn't working. Sorry about that.

To do the group search on this just go to: https://depatisnet.dpma.de/DepatisNe...ion=einsteiger

Type in "Transdermal treatment with 5-alpha reductase inhibitors " in the Title box... then click on "Recherche starten" on the bottom... then click on the "Suchen" button on the very right.

[RU58841]

Interesting find, stratowich, good job. Wish I knew more.

[stratowich]

Hey, I'm totally fine if somebody proves me wrong, but does Merck actually hold a valid patent for topical finasteride?

This is the patent application if I'm not mistaken: https://depatisnet.dpma.de/DepatisNe...020020042425A1

The filling number ends in "A1", meaning that they applied for the patent but it actually never became valid, as there would need to be another filling number ending in "B" for this application.

However, as you can see from the following group search, Merck does hold a few patents which utilize finasteride for other topical applications (i.e. acne):

https://depatisnet.dpma.de/DepatisNet/depatisnet?window=1&space=main&content=treffer&action=treffer&famSearchFromHitlist=1&firstdocFam1=51&so=asc&sf=vn

None of them are specifically for AA thought. And the few patents Mercks hold are basically only valid in the US. This would explain why topical finasteride is only sold by a few pharmacies in Canada (Pharmacy related to Hasson&Wong), Europe (Farmacia Parati) and (considering Desmonds posts from earlier) now in Australia.

But as I said in the beginning, I'm not totally sure if this is really the full truth behind this, please correct me if I'm wrong.

[RU58841]

It just seems very very strange that we are basically left to making this topical finasteride by ourselves!

Why isn't there a big medical company that sees the potential and wants to make money out of this?
There would be potentially millions of men around the world that would be interested in proven, effective topical finasteride with less sides compared to the pill version. If this topical version was branded and available in normal pharmacies globally!
Can somebody explain this to me, please?

Purportedly Merck considers sales of finasteride to be "disappointing" even though it (again purportedly) outsells minoxidil 10:1. Combined with a low percentage of people who actually bother to treat their hair loss, a less convenient topical that probably makes the hair look not so good with potential for some, if maybe less severe, sexual side effects probably doesn't seem like a very lucrative product for them. Besides, look how many people on here are afraid to even touch oral finasteride due to the low possibility that they might get temporary side effects.

To tell you the truth, I never even felt comfortable using Tylenol for headaches. Now I'm dousing my head with a homemade solution with unknown long-term effects, purchased over the internet from a Chinese laboratory. Guess this is a hobby only for the most dedicated enthusiasts.