Where are the phase IIb results for Bimatoprost?

[It's2014ComeOnAlready]

Can you tell me then how they possibly managed to get away with phase 3 being a secretive test? Doesnt that have to be disclosed or am i pulling s_ out of thin air again?

and if it does have to be disclosed, then that means they haven't started phase 3 yet and it would be another year from now, right?

I have my own interpretation, and I have no interest in going back and forth over it with you.

I also never said you're pulling sh-- out of thin air. I simply said that I wasn't. I think you have some reading comprehension issues.

I'm not here to try and comfort you with explanations etc, I only post what I find. If you want my thoughts on the phase 3, you can go and look for it in this thread. I'm not going to go over it again.

[JayM]

i have my own interpretation, and i have no interest in going back and forth over it with you.

I also never said you're pulling sh-- out of thin air. I simply said that i wasn't. I think you have some reading comprehension issues.

I'm not here to try and comfort you with explanations etc, i only post what i find. If you want my thoughts on the phase 3, you can go and look for it in this thread. I'm not going to go over it again.

preach

[unbalding]

dude, i have used this http://www.scbt.com/datasheet-222336-tafluprost.html . It's WAYYYYYYYYYYYYY~~~~~ than bimatoprost. Did nothing and even accelerated shedding. On top of that- it caused nerve pain in my left arm and some tinnitus in my right ear. Furthermore, Dr Cotsarelis's PGD2 study already stated that PGF2a levels are slightly elevated in bald scalp when compared to haired-scalp. U are going to get disappointed BIGTIME if you still pin all that hope on Bimatoprost.

Rumor had it when the phase 2 trial ended that the results were superior to minoxidil. The fact that one person experimented with something similar to bimatoprost, in small doses, and had no results, is not in any way scientifically meaningful. Let's just wait for them to announce their results, ok?

[lifelonglearning]

Found this interesting

http://www.ncbi.nlm.nih.gov/pubmed/25765294

"Bimatoprost solution represents a therapeutic option for scalp AA."

[rdawg]

Found this interesting

http://www.ncbi.nlm.nih.gov/pubmed/25765294

"Bimatoprost solution represents a therapeutic option for scalp AA."

"All responding AA patches showed significant reduction in their SALT score after therapy. Area B demonstrated significantly better results regarding rapidity of response in weeks, percentage of hair re-growth and side effects compared to area A."

It clearly has an affect on hair, even at low doses, just needs a higher dose, I have no doubt that it works it's just is it to the extent that BIM can sell it over minoxidil? I think the problem here is, is it marketable? is it 10% better than min, 20%, 50% etc. if it's only 5-10% better and will cost ten times more, it may not be worth it to release.

[lifelonglearning]

Well minoxidil doesnt work for everyone and causes initial shedding so as long as bim regrows and thickens

just saying (1) works for 100% of people and (2) causes no initial shed should be enough to market it

[dutchguyhanging]

Well minoxidil doesnt work for everyone and causes initial shedding so as long as bim regrows and thickens

just saying (1) works for 100% of people and (2) causes no initial shed should be enough to market it

well u dont have to state the obvious. any treatment which comes to the market should be 100% proven works for everyone. otherwise there is no money... either cure or fin minox

[Hubris]

well u dont have to state the obvious. any treatment which comes to the market should be 100% proven works for everyone. otherwise there is no money... either cure or fin minox

I disagree. Minoxidil doesn't work for everyone and neither does finasteride. It isn't a reasonable standard to expect a drug to work for all people. It only needs to be significantly more effective than minoxidil for the majority of people in order to come to market.

[lifelonglearning]

well u dont have to state the obvious. any treatment which comes to the market should be 100% proven works for everyone. otherwise there is no money... either cure or fin minox

" While topical minoxidil exhibits a good safety profile, the efficacy in the overall population remains relatively low i.e., 30-40% re-grow hair"

https://www.clinicaltrials.gov/ct2/show/NCT02198261

[Hemo]

well u dont have to state the obvious. any treatment which comes to the market should be 100% proven works for everyone. otherwise there is no money... either cure or fin minox

No treatment works for 100% of people. Even if it only works for 60% of users, if it's easier to apply and/or more effective then it's worth bringing to market. Long term effectiveness of minox is nowhere close to 100%.

[burtandernie]

"All responding AA patches showed significant reduction in their SALT score after therapy. Area B demonstrated significantly better results regarding rapidity of response in weeks, percentage of hair re-growth and side effects compared to area A."

It clearly has an affect on hair, even at low doses, just needs a higher dose, I have no doubt that it works it's just is it to the extent that BIM can sell it over minoxidil? I think the problem here is, is it marketable? is it 10% better than min, 20%, 50% etc. if it's only 5-10% better and will cost ten times more, it may not be worth it to release.

Some men will pay that premium even for 10 percent better results though. What other choice do you have its still cheaper than other options. Something is always better than nothing and this might work for people that fail at the other treatments since really only minox regrows anything. It surely has a good market if it works at all.

[rdawg]

Some men will pay that premium even for 10 percent better results though. What other choice do you have its still cheaper than other options. Something is always better than nothing and this might work for people that fail at the other treatments since really only minox regrows anything. It surely has a good market if it works at all.

Companies wont agree with this unless they see a profit, this is the same thing that happened with that other drug RU, it definitely had efficacy on hair but the company felt it wasnt marketable enough to sell more than FIN was already(plus one is a simple pill, the other was a topical)

Companies at the end of the day obsess over profit, if they feel it's not worth putting through a 200 million dollar trial even though it works a little bit there is nothing we can do.

[Occulus]

Some men will pay that premium even for 10 percent better results though. What other choice do you have its still cheaper than other options. Something is always better than nothing and this might work for people that fail at the other treatments since really only minox regrows anything. It surely has a good market if it works at all.

Exactly. Hell, you can make millions selling a bunch of herbs that has no affect on hair growth at all just by claiming it does. You can make a hundred million dollars by selling a concoction that is simply minoxodil (it's been done before). Something that can grow 10% more than Rogain immediately takes the market from Rogain. If Rogain sells, something that is 10% more effective will sell a lot more.

[dutchguyhanging]

No treatment works for 100% of people. Even if it only works for 60% of users, if it's easier to apply and/or more effective then it's worth bringing to market. Long term effectiveness of minox is nowhere close to 100%.

thats the thing of it. we can not quantify the number and we will never be. it has to be something without doubt will work for everyone. until that day comes, minox and fin seems to be the only viable treatment.

and i dont think any big pharma will release any product unless it is the cure. lets be honest no one wants to take these drugs forever...

hairloss is a big market.. from what i see only 20-30% are actually taking these drugs... if there is a cure im sure everyone will buy it. speaking of myself I can pay up to 70 grand.. just make me NW0 without any sides and taking further drugs. and I know a lot of people who can afford that.

in other words there is a demand in the market but supply is not good enough. so buyers are not attracted and running away from the market...

[It's2014ComeOnAlready]

May not mean anything, but given what's been going on I found this tweet from Allergan CEO, Brent Saunders, interesting.

Oct 17, 2015

"Committed to expanding the aesthetics market for men."

Also posted were websites with information about botox for men, as well as a study published last week regarding men, aesthetic medicine treatments, like botox, injectables etc. and what they would be likely to use, or interested in the most. Also included what subjects they were most likely to talk about with their dermatologist. The top were hair loss and facial wrinkles. A new hair loss treatment would be expanding the aesthetics market for men. Let's hope that's what he means, but I feel good about this.