follicept - what's this?

[Jonathan]

Correct, lots of people have products containing IGF-1 because the science is sound. But most of these products are not actually or effectively delivering the compound. The novelty of our product is the underlying TopiconTM technology, which delivers large molecules across the skin. This allows us to actually deliver the compound to its intended definition, and at low concentrations that greatly reduces the risk of negative side effects.

How come You focus on IGF-1 and not on a drug that is already proven to work against hair loss? Finansterid is working fine, the only problem is its side effects. For a layman that sounds like the obvious selection for your delivery system. An effective micro dose of Finansteride without side effects would be a life changer for millions of men and woman. Why are you choosing IGF-1 that has none/short track record in human hair loss and has some scary sides if overdosed..?

I understand it must be a heavy pressure on you with all this interest, questions and lack of patience from us. I tried to stay quiet as long as I could not to add additional load on you, but its too hard :-) But I am certain that when you succeeded with Follicept and look back at this, you will think that it was all worth it. Good luck buddy.

[nameless]

Some people on this board are funny. When a company shares to much, to early they are critized. And when a company shares to little they are critized and are said to be MIA. Like what do you people want?

Devon/folicept have done a great job of trying to keep us in the loop as they receive information. They haven't asked for any money from us (eventhough I've offered). And They've been honest about their results and their timelines.

You right about the posters here. Most of them anyways. If the company won't share secrets the posters get angry and if the company does share secrets the posters get mad about that. Most of the posters here are like PMS women who can't make up their minds.

[Gbalding]

How come You focus on IGF-1 and not on a drug that is already proven to work against hair loss? Finansterid is working fine, the only problem is its side effects. For a layman that sounds like the obvious selection for your delivery system. An effective micro dose of Finansteride without side effects would be a life changer for millions of men and woman. Why are you choosing IGF-1 that has none/short track record in human hair loss and has some scary sides if overdosed..?

I understand it must be a heavy pressure on you with all this interest, questions and lack of patience from us. I tried to stay quiet as long as I could not to add additional load on you, but its too hard :-) But I am certain that when you succeeded with Follicept and look back at this, you will think that it was all worth it. Good luck buddy.

I had a consult with Dr Hasson in Vancouver and he told me that to bring a FDA approved drug to market with a new delivery system would cost upwards of a half a billion dollars.

These guys got lucky with their "cosmetic" designation, and can bring it to market without having to spend such an exuberant amount of money. If they decided to do the exact same thing with Minoxidil, DUT, or Fin odds are we would've never heard of them.

[nameless]

How come You focus on IGF-1 and not on a drug that is already proven to work against hair loss? Finansterid is working fine, the only problem is its side effects. For a layman that sounds like the obvious selection for your delivery system. An effective micro dose of Finansteride without side effects would be a life changer for millions of men and woman. Why are you choosing IGF-1 that has none/short track record in human hair loss and has some scary sides if overdosed..?

I understand it must be a heavy pressure on you with all this interest, questions and lack of patience from us. I tried to stay quiet as long as I could not to add additional load on you, but its too hard :-) But I am certain that when you succeeded with Follicept and look back at this, you will think that it was all worth it. Good luck buddy.

He has answered this question numerous times. He says that he may do that down the road, but doing so with those medicines will require phase 1, phase 2, and phase 3 studies because they're actual medicines.

[Jonathan]

I had a consult with Dr Hasson in Vancouver and he told me that to bring a FDA approved drug to market with a new delivery system would cost upwards of a half a billion dollars.

These guys got lucky with their "cosmetic" designation, and can bring it to market without having to spend such an exuberant amount of money. If they decided to do the exact same thing with Minoxidil, DUT, or Fin odds are we would've never heard of them.

If they could show that the delivery system can deliver Fin to where its supposed to go and nowhere else, I don't think there would have been any problems to find investors. However 500 millions to change delivery method of a well proven drug sounds like an exaggeration.

[follicept]

Yes, Most Definitely, thank you Devon very much.

Since you are openly sharing your concept here, do you have IP protection on your TopiconTM technology?

Yes, we have several patents filed.

[follicept]

Well if you are not using the human version and it doesn't work then you might think that this approach won't work but it might have worked if you had used the human version. I strongly recommend using the human version or else if it fails you will always wonder if it might have worked if you had used the human version. Also, if you don't use the human version and it doesn't work then you could give up on this treatment idea, but 5 years from now someone could try the human version, it might work, and then you will kick yourself in the behind for not trying the human version 5 years earlier.

My advice: use the human version.

Haha, yeah definitely using the human version- confirmed with the team.

[follicept]

How come You focus on IGF-1 and not on a drug that is already proven to work against hair loss? Finansterid is working fine, the only problem is its side effects. For a layman that sounds like the obvious selection for your delivery system. An effective micro dose of Finansteride without side effects would be a life changer for millions of men and woman. Why are you choosing IGF-1 that has none/short track record in human hair loss and has some scary sides if overdosed..?

I understand it must be a heavy pressure on you with all this interest, questions and lack of patience from us. I tried to stay quiet as long as I could not to add additional load on you, but its too hard :-) But I am certain that when you succeeded with Follicept and look back at this, you will think that it was all worth it. Good luck buddy.

Thanks for that! I know it will. If you'd prefer, we can drop IGF-1 and go after finasteride. We'll just need to ask you guys for about $50M and we promise we'll have that product first thing in 2020.

IGF-1 has a history in studies, but the implementation has been the issue. We have a new delivery system, and a chance to get it out there quickly. We're gonna take it.

[follicept]

You right about the posters here. Most of them anyways. If the company won't share secrets the posters get angry and if the company does share secrets the posters get mad about that. Most of the posters here are like PMS women who can't make up their minds.

Blame it on the DHT?

[follicept]

I had a consult with Dr Hasson in Vancouver and he told me that to bring a FDA approved drug to market with a new delivery system would cost upwards of a half a billion dollars.

These guys got lucky with their "cosmetic" designation, and can bring it to market without having to spend such an exuberant amount of money. If they decided to do the exact same thing with Minoxidil, DUT, or Fin odds are we would've never heard of them.

Bingo.

[rhysmorgan]

I'm astonished at the amount of hope people are putting in a treatment that's only been used in a rat or mouse model. It seems people don't learn a thing.

Wait until human trial results to even begin thinking about 100 page threads on here. Jesus people.

[sdsurfin]

Thanks for that! I know it will. If you'd prefer, we can drop IGF-1 and go after finasteride. We'll just need to ask you guys for about $50M and we promise we'll have that product first thing in 2020.

IGF-1 has a history in studies, but the implementation has been the issue. We have a new delivery system, and a chance to get it out there quickly. We're gonna take it.

Wow, that's ludicrous and pretty disconcerting. Why does it cost so much money? Is that how much it costs to bring a new drug to market as well?

[DanWS]

I'm astonished at the amount of hope people are putting in a treatment that's only been used in a rat or mouse model. It seems people don't learn a thing.

Wait until human trial results to even begin thinking about 100 page threads on here. Jesus people.

Lol. You're telling people to not discuss a potential future treatment for hair loss... on a future treatment for hair loss forum. Perhaps if you allow us to continue this "100 page" thread that has you feeling perturbed, we might eventually "learn a thing" and reach your level of knowledge. Please be patient with us peon masses. Ty.

[FooFighter]

I'm astonished at the amount of hope people are putting in a treatment that's only been used in a rat or mouse model. It seems people don't learn a thing.

Wait until human trial results to even begin thinking about 100 page threads on here. Jesus people.

+1 I think the same. Until i dont see before/after pictures with 40/50 humans in trials i dont put so much hope in any treatment. We have been burned so many times. Everything works on mouses, but only on mouses, lol!

[NeedHairASAP]

2011 Oct;21(5):260-7. doi: 10.1016/j.ghir.2011.07.003. Epub 2011 Aug 11.
Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae.
Zhao J1, Harada N, Okajima K.
Author information

Abstract
We demonstrated that insulin-like growth factor-I (IGF-I) production in dermal papillae was increased and hair growth was promoted after sensory neuron stimulation in mice. Although the androgen metabolite dihydrotestosterone (DHT) inhibits hair growth by negatively modulating growth-regulatory effects of dermal papillae, relationship between androgen metabolism and IGF-I production in dermal papillae is not fully understood. We examined whether DHT inhibits IGF-I production by inhibiting sensory neuron stimulation, thereby preventing hair growth in mice. Effect of DHT on sensory neuron stimulation was examined using cultured dorsal root ganglion (DRG) neurons isolated from mice. DHT inhibits calcitonin gene-related peptide (CGRP) release from cultured DRG neurons. The non-steroidal androgen-receptor antagonist flutamide reversed DHT-induced inhibition of CGRP release. Dermal levels of IGF-I and IGF-I mRNA, and the number of IGF-I-positive fibroblasts around hair follicles were increased at 6h after CGRP administration. DHT administration for 3weeks decreased dermal levels of CGRP, IGF-I, and IGF-I mRNA in mice. Immunohistochemical expression of IGF-I and the number of proliferating cells in hair follicles were decreased and hair re-growth was inhibited in animals administered DHT. Co-administration of flutamide and CGRP reversed these changes induced by DHT administration. These observations suggest that DHT may decrease IGF-I production in dermal papillae by inhibiting sensory neuron stimulation through interaction with the androgen receptor, thereby inhibitinghair growth in mice.
Copyright © 2011 Elsevier Ltd. All rights reserved.

2014 Mar;23(3):216-8. doi: 10.1111/exd.12339.
Insulin-like growth factor-1: roles in androgenetic alopeci