follicept - what's this?

[Helix]

Well you ask the same question 3 times what do you want me to do?

How is it speculation? Perhaps you'll go argue that the fact that pseudohermaphrodites or AIS people don't display androgenetic alopecia is speculation or not important? I'ts totally relevant to extrapolate data of such genetic diseases to AGA. In fact we have done this and discoveries are often made through this way.

People with Acrogemaly can display AGA, don't they? Then how can the FOXO1 hypothesis occur? Please explain, I'm interested in what you have to say.

You say that I speculate but don't give argumentation of anything at all. Aside from pointing me on carrier proteins (IGFPB family). Anyone on wikipedia can read about that lol.

I was asking you the same question because I expected a reference not your personal observation.

You can't predict what effect will IGF-1 have on tissue level based on conditions with high circulating IGF-1. That is a speculation. You just don't know.

I have no idea what FOXO1 hypothesis is. I am not giving argumentation because I am not a molecular biologist and I am not pretending to be one. I'm just pointing to a logical fallacy that you committed.

[It's2014ComeOnAlready]

BS to this working. It's snakeoil until it's proven to be better than minoxidil. A guy pandering to a forum of desperate ppl, is likely to be full of crap. Just look at how many views this thread has gotten...based on what?

[Swooping]

I was asking you the same question because I expected a reference not your personal observation.

You can't predict what effect will IGF-1 have on tissue level based on conditions with high circulating IGF-1. That is a speculation. You just don't know.

I have no idea what FOXO1 hypothesis is. I am not giving argumentation because I am not a molecular biologist and I am not pretending to be one. I'm just pointing to a logical fallacy that you committed.

Oh I definitely didn't mean to imply that. Sorry English isn't my native language and I mostly type from a mobile phone. You are correct about that. Local secretion may be way different than circulating levels. In fact local secretion may have way different action on the hair follicle than circulating levels. And that's most likely the point anyway.

Then again given everything I really see no chance of this working. But I'll say it again, we'll see!

[Helix]

Oh I definitely didn't mean to imply that. Sorry English isn't my native language and I mostly type from a mobile phone. You are correct about that. Local secretion may be way different than circulating levels. In fact local secretion may have way different action on the hair follicle than circulating levels. And that's most likely the point anyway as studies show this.

Then again given everything I really see no chance of this working. But I'll say it again, we'll see!

Well, me neither (but I sure hope it will). Anyway, I'm glad we finally agree.

[FrenchNewbie]

Hi Devon, very pragmatic questions here. Please explain us your strategy about price. I understood that this product can work with 3 applications by a week during 1 month. Then, it can works for one year. So, if i compare with the price in euro of Rogaine 5% (in France), it's 70 euros for 4 months (general price). So, for a year we have a price of 210 euros.

In US, i found on Amazon.com a price of 40 dollars for 3 months. So 160 dollars a year. 1 euro=1,07 dollar (same thing).

What will be your strategy if it works? I understood that it will not be 50 dollars. So 100 dollars? 150 dollars? 200 dollars? 250 dollars? Or more?

My point of view: the better price is 150 dollars for one year. Europeans will be very happy, cause our price is 210 euros for Rogaine. And US users will be happy too, cause the price is 160 dollars for them.

I think it could be interessant to create a subscription to an offer of 2, 3 or 4 years. So the price could be cheaper by bottle. For exemple: I take a suscribtion of 3 bottle for 3 years, i have to pay 350 dollars (instead of 450 dollars, if one bottle cost 150 dollars). So, i have a price of 116 dollars by year. And each year Follicept send a new bottle. With this method you can increase you revenu generated for the first year. With that money you can better finance the developpement of Follicept (and others).

I know that you will have to adjust your strategy and you can't say more. But if it works, some people need to be prepared for the first of june (i'm thinking about young without big budgets for exemple). So we need indications.

Second question: Will you permit multiple buying via Indiegogo (at normal price)? If Follicept works i think that you will have a big buzz all over the world (you can't imagine). So, I will prefere to buy 2 or 3 packs to be sure i have it for a long term. And i could buy one more for my brother who start with allopecia but doesn't wan't to treat it.

Third question: Do you know the expiration of this product? Will it works 2 months, 6 months, 2 or 3 years after buying it (if the bottle is sealed)?

Fourth question: If it really works, do you need our help? I think i'm not the only person who want graciously help you here. I have some skills in website developpement and design. I can create your french and spanish version of the website, or just give you the translations texts in the best french or spanish. I can create you a forum like this (with a better design ), to give the possibility to buyers to share their photos and ask questions to create a real "Follicept community" (without troll that we have here ). And I think some members here, could be moderators with smile (and a lot of hair... i hope). I know some journalists in France too. I graciously offer my help.

Excuse my english dear Deavon. I'm so frustrated, i can't explain my ideas like i want. And i can't say clearly my gratefulness. You take a lot of time to explain. And now, you will give your hairs and your head to the science. I saw all your campaign for diabetes. You are human and very courageous Devon. And i know that it's nothing in comparison with your work everyday. So man, even if it doesn't work: THANK YOU! And THANK YOU to Dr. HSU to try!

[baldie42]

It only takes 2 weeks for finasteride to leave the system doesn't it?

Wrong.I no longer take propecia after using for several years.If your on propecia stay on it.It will take along time for your hormones to get back to normal. - I will not go into full details it will scar the sh*t out of you.Take a look at propeciahelp - I'm at the back end of it now after 12 months hopefully.
I had no side effects while using propecia.
I stopped because I'm getting older and have learned to accept going bald a little easier.quite a lot of men my age are showing hairloss or bald.I accept it easier because I shave my hair off,as this looks better than a balding look.I wouldn't mind a full hair shadow -I keep hoping.

Good luck Follicept

[FrenchNewbie]

Finasteride will leave the system in two or three weeks. The probleme is not here. Finasteride change the hormone balance in your body. It touch your male hormone (which is one of the most important for a man). So it will take a lot of time (maybe 2 or 5 years) to get back to normal. I read a lot of persons who took this sh*t. A lot have side effects that no stop after stopping Fin. So, with Follicept, some people need to be cautious.

[thejack]

Finasteride will leave the system in two or three weeks. The probleme is not here. Finasteride change the hormone balance in your body. It touch your male hormone (which is one of the most important for a man). So it will take a lot of time (maybe 2 or 5 years) to get back to normal. I read a lot of persons who took this sh*t. A lot have side effects that no stop after stopping Fin. So, with Follicept, some people need to be cautious.

This is what I am concerned about, I have been taking it for 7 years now. I have had no side effects though and have been through at least 3 weeks of no finasteride due to travelling and had no change in my body; I will probably just continue and use follicept simultaneously if it is successful.

[FrenchNewbie]

@Thejack It's your case bro'. I'm happy for you but all cases are different with hormons.

[Illusion]

Regarding the whole 'dropping everything and getting on follicept' thing, I feel that you guys should also compare follicept to finasteride (and maybe a finasteride + minoxidil combination as well). I have read about trialling follicept along with minoxidil to compare the results, but if you guys are going to claim that it's a stand alone treatment then you guys should compare it to finasteride as well. So that would mean trialling follicept along with minoxidil and finasteride.

But I guess you guys at Promotheon have already thought about that?

[GSD]

@frenchnewbie

maybe you talk about 0,01 % people who got permanent or long term side effects . please dont speak about a drug which you never tried.

[NeedHairASAP]

Regarding the whole 'dropping everything and getting on follicept' thing, I feel that you guys should also compare follicept to finasteride (and maybe a finasteride + minoxidil combination as well). I have read about trialling follicept along with minoxidil to compare the results, but if you guys are going to claim that it's a stand alone treatment then you guys should compare it to finasteride as well. So that would mean trialling follicept along with minoxidil and finasteride.

But I guess you guys at Promotheon have already thought about that?

I understand how minox (a topical) could get caught up in follicepts vehicle, thus delivering too much minox and giving you a heart attack.

But I don't understand why one would have to stop oral fin while on follicept. It's not like oral fin is going to get caught in follicepts vehicle and deliver too much.....

I think devon mean that trialists shouldn't be on either med--- for the purpose of evaluating follicept. Not so much that you can't stay on fin and use follicept. But you should be weary for sure of any topical (e.g. minox or topical fin)

[follicept]

Regarding the whole 'dropping everything and getting on follicept' thing, I feel that you guys should also compare follicept to finasteride (and maybe a finasteride + minoxidil combination as well). I have read about trialling follicept along with minoxidil to compare the results, but if you guys are going to claim that it's a stand alone treatment then you guys should compare it to finasteride as well. So that would mean trialling follicept along with minoxidil and finasteride.

But I guess you guys at Promotheon have already thought about that?

We have and we will, once funding allows. First, we will just test the efficacy of Follicept in treatment-naive patients.

[follicept]

Hi Devon, very pragmatic questions here. Please explain us your strategy about price. I understood that this product can work with 3 applications by a week during 1 month. Then, it can works for one year. So, if i compare with the price in euro of Rogaine 5% (in France), it's 70 euros for 4 months (general price). So, for a year we have a price of 210 euros.

In US, i found on Amazon.com a price of 40 dollars for 3 months. So 160 dollars a year. 1 euro=1,07 dollar (same thing).

What will be your strategy if it works? I understood that it will not be 50 dollars. So 100 dollars? 150 dollars? 200 dollars? 250 dollars? Or more?

My point of view: the better price is 150 dollars for one year. Europeans will be very happy, cause our price is 210 euros for Rogaine. And US users will be happy too, cause the price is 160 dollars for them.

I think it could be interessant to create a subscription to an offer of 2, 3 or 4 years. So the price could be cheaper by bottle. For exemple: I take a suscribtion of 3 bottle for 3 years, i have to pay 350 dollars (instead of 450 dollars, if one bottle cost 150 dollars). So, i have a price of 116 dollars by year. And each year Follicept send a new bottle. With this method you can increase you revenu generated for the first year. With that money you can better finance the developpement of Follicept (and others).

I know that you will have to adjust your strategy and you can't say more. But if it works, some people need to be prepared for the first of june (i'm thinking about young without big budgets for exemple). So we need indications.

Second question: Will you permit multiple buying via Indiegogo (at normal price)? If Follicept works i think that you will have a big buzz all over the world (you can't imagine). So, I will prefere to buy 2 or 3 packs to be sure i have it for a long term. And i could buy one more for my brother who start with allopecia but doesn't wan't to treat it.

Third question: Do you know the expiration of this product? Will it works 2 months, 6 months, 2 or 3 years after buying it (if the bottle is sealed)?

Fourth question: If it really works, do you need our help? I think i'm not the only person who want graciously help you here. I have some skills in website developpement and design. I can create your french and spanish version of the website, or just give you the translations texts in the best french or spanish. I can create you a forum like this (with a better design ), to give the possibility to buyers to share their photos and ask questions to create a real "Follicept community" (without troll that we have here ). And I think some members here, could be moderators with smile (and a lot of hair... i hope). I know some journalists in France too. I graciously offer my help.

Excuse my english dear Deavon. I'm so frustrated, i can't explain my ideas like i want. And i can't say clearly my gratefulness. You take a lot of time to explain. And now, you will give your hairs and your head to the science. I saw all your campaign for diabetes. You are human and very courageous Devon. And i know that it's nothing in comparison with your work everyday. So man, even if it doesn't work: THANK YOU! And THANK YOU to Dr. HSU to try!

All of this is to be determined, but we are thinking along the same lines. We will test expiration but it is very stable at room temperature, and especially in the freezer.

Thanks so much for the offer to help, we will reach out if/when we need it! Don't call us heroes yet, we are just trying something new.

[FrenchNewbie]

@GSD I speak about it because I have a friend who had a lot of side effects during and after taking it during 5 years. He took 25 kilos. He was depressive during 5 years and now he take Seroplex 20mg since 7 years (he told me it's a big dose). He wanted many times suicide himself. He lost his libido and he divorced (for a lot of things, but Fin was the trigger). He lost a lot of his friends. And you want to know the best? He has now no hair on the top of his head. And now he has so much problems that hair is not a priority at all for him.

It's the reason why I don't want take Fin and I will never take it.

I know that a lot of persons don't have any problem with Fin. But i don't think it's 99,99% of the people who take it. I have no statistics but by viewing forums i can imagine 50% have side effects with Fin and 20% are serious, 5% are very serious. Even if it was 1%, the risk is too big. Trust me, you don't want to live what he lives.