OC info+ use RU at your own risk

[JDW]

Best option is to wait for the poc trial to be completed with Kythera. Then we will have concrete data on humans seeing how effective gpr44 blockers really are. Will also know correct dosage, safety and health risks etc

When is this set to be completed? thanks

[hellouser]

Best option is to wait for the poc trial to be completed with Kythera. Then we will have concrete data on humans seeing how effective gpr44 blockers really are.

You'll be waiting 2 years for that.

[HairlossAt15]

Best option is to wait for the poc trial to be completed with Kythera. Then we will have concrete data on humans seeing how effective gpr44 blockers really are. Will also know correct dosage, safety and health risks etc

[Jasari]

OC is around 220 on Kane's site for 1 gram. What is the mixing & storage procedure & how long does this last?

A one month treatment is far from economical.

[nave13579]

Just got this email from Anagen:

"dear friend,

Our Head Manufacture kane in china is still on holiday. back at 27-2.

re setipiprant, once they're back.

1). they'll check if this chemical is patented in china.
2). they'll check if chemical is licensed by any drug distributor.
3). As if its licensed they'll,contact the company for agreement to produce and sell this research chemical strictly as for research purpose not for human use.in small quantities. there is no guarantee for grand production right at high quantity if drugs is licensed already.
4). price for small scale production for research purpose only. won't be economical.


as for OC000459, oc000459-ethanol and TM , both very selective CRTH2 antagonists, please tell them the quantity you're interested in, they'll give a great discount for volume deal. We have both products are in stock.
You can arrange a group buy if there is interest. please let me know the total quantity."

[FeelsBad]

No need for that, sdsurfin. I am with you and I will totally try OC/Setipiprant if the price comes down a little. I appreciate you putting in time on this.

[sdsurfin]

Fine, you fools can all keep burning your nuts and your brains off while there is very possibly much better option out there. I think a combo of a blocker and Bim will definitely do a lot of good, and I would appreciate the support needed to make that happen. If all you want to do is use finasterude then just keep your mouth shut. Unless you have solid scientific evidence that cotsarellis and kythera are wrong about pursuing this.

[sdsurfin]

Swooping that is all speculative, and honestly maybe it's not a holy grail, but cotsarellis did find a pharmacparner did his research very quickly and sold them the rights to all their research. These guys know things we don't know, and I can't find any reason this wouldn't maintain as well as fin. And many of us don't want to use anti androgens. So please stop bringing this down when you have really no good reason not to and very reputable people are investing in it. Any online posters have reported a stoppage in shedding on all kinds if pgd2 blockers, even Zyrtec which biscuits different receptor. Anything that can ride me over safely for a few years is golden in my book. The guy at the pharmacy is willing to work with us on SM and Bim too.

Ps forgive the typos I'm on a phone.

[sdsurfin]

Swooping that is all speculative, and honestly maybe it's not a holy grail, but cotsarellis did find a pharmacparner did his research very quickly and sold them the rights to all their research. These guys know things we don't know, and I can't find any reason this wouldn't maintain as well as fin. And many of us don't want to use anti androgens. So please stop bringing this down when you have really no good reason not to and very reputable people are investing in it. Any online posters have reported a stoppage in shedding on all kinds if pgd2 blockers, even Zyrtec which biscuits different receptor. Anything that can ride me over safely for a few years is golden in my book. The guy at the pharmacy is willing to work with us on SM and Bim too.

[KO1]

I think there is merit to the Pgd2 angle, as Garza wrote a paper that PGD2 inhibited WIHN, hitch leads me to believe it is one of the things that is inhibiting regrowth potential. But, again unclear if fin already covers this.

[Swooping]

Swooping, I know you're knowledgable but you're being pretty negative here.
The trials were all pretty short, the longest was 3 months I think. Here's one: https://www.clinicaltrials.gov/ct2/s...piprant&rank=1
That's definitely not long enough to notice maintenance, and probably not long enough to notice regrowth either since it takes around 3-4 months for new hairs to grow to a reasonable amount.

It's not only that. In my opinion the whole PGD2 angle is overrated. Literally nobody even followed up Cotsarelis his work or came with the same findings or even directs his focus to the PGD2 angle in androgenetic alopecia. Many other researchers and groups are literally paving in a whole different direction and don't even mention the whole PGD2 angle. That's just extremely odd to me.

Also what is just extremely hard argumentation is that these molecules are more selective but we have had many medicines on the market manipulating prostaglandines and still have. What about all the even (deadly) cox-2 inhibitors that have been on the market? PGD2 is mediated from this enzyme. What about the other more selective medicines? Why would setipiprant be different? How high would the chance be, that there still isn't any real evidence of them being effective?

Also the in vitro explant hair follicle model is odd. The hair follicle did elongate even when PGD2 was administered albeit less than without PGD2 just check the presentation. It's not that this is special at all or acts as a valid argument. You can stop elongation with many things like for instance tgf-b in vitro.

https://www.youtube.com/watch?v=TN5H01HGaVI&feature=youtu.be&t=19m41s

Anyways we'll see.

[Justinian]

That's hilarious. I didn't even know that it was licensed out. Good move by Actelion, they obviously wanted to get rid of it after the fails. Also, If it would have a significant impact on hair they would have noticed that in the clinical trials (8 of them were run in 1000+ patients) and would never have licensed this treatment out imo. After all the safety was pretty much established. Kythera is drunk I guess. I'll eat my shoe if this will be proven to be more effective than finasteride. But we'll see.

Swooping, I know you're knowledgable but you're being pretty negative here.
The trials were all pretty short, the longest was 3 months I think. Here's one: https://www.clinicaltrials.gov/ct2/s...piprant&rank=1
That's definitely not long enough to notice maintenance, and probably not long enough to notice regrowth either since it takes around 3-4 months for new hairs to grow to a reasonable amount.

[Swooping]

See, thing is Kythera didn't actually purchase it. They are licensing it, where they develop it as a treatment, but Actelion gets royalties from it. No cost to Actelion.

Ahh explains it, thanks.

[KO1]

See, thing is Kythera didn't actually purchase it. They are licensing it, where they develop it as a treatment, but Actelion gets royalties from it. No cost to Actelion.

[sdsurfin]

Also TM setipip and OC are all very similar. Whichever one we can get at a normal price will be good to test.