OC buy

[nave13579]

I would rather address the downstream problem as opposed to upstream, allowing more natural processes in my body to remain unblocked and functional.

[Hairismylife]

I would rather address the downstream problem as opposed to upstream, allowing more natural processes in my body to remain unblocked and functional.

Add some antiandrogen at very low dose.
Mpb need to be attacked in all angles!

[KO1]

Good points. I definitely think we need to add PGE2 concurrently with seti, and it will magnify pgd2 inhibition. What's more, pge2 is already available in drug form.

[sdsurfin]

I would rather address the downstream problem as opposed to upstream, allowing more natural processes in my body to remain unblocked and functional.

Exactly. Downstream means more specific. Also OC and setipip do not reduce PGD2 the way fin reduces DHT. they block a very specific receptor in the follicle, and there is still the same amount of PGD2 floating around interacting with the other receptors in your body. People don't seem to understand that. This is hands down a less invasive approach, and one that avoids ****ing with crucial hormonal balances, Which is why A billion dollar drug company is investing to bring this to market. I don't need to say anything more than that. If they did not see a superiority to finasteride then they would not be researching it and developing it.

Also swooping I don't think you understand how these drugs differ in their mechanism. Fin does not block any receptors, it inhibits an enzyme. This action is not linked to upregulation. In contrast, when you block a receptor site, this often results in the creation of more receptors on a cell. Look up beta blockers. I'm not saying RU definitely up regulates androgen receptors, but the possibility is there.

I really don't want to argue about anti-androgens. In my experience they all give me side effects, and are tied to hormonal pathways that are just too important for my health and identity as a man to **** with. If you want to roll those dice, go ahead.

My goal is to bring to market an option that has top scientists behind, it, that has PROVEN safety as opposed to RU, and that at least has very strong anecdotal evidence of success at halting loss. Breathlessness is something that every person with anxiety experiences, and neither that or insomnia really scare me, especially if they are mild. The worst that can happen is you get those sides and decide to stop. The worst that can happen on fin is that you get sides and they never go away. I personally know people who this has happened to. For me the choice is simple.

[Swooping]

Also swooping I don't think you understand how these drugs differ in their mechanism. Fin does not block any receptors, it inhibits an enzyme. This action is not linked to upregulation. In contrast, when you block a receptor site, this often results in the creation of more receptors on a cell. Look up beta blockers. I'm not saying RU definitely up regulates androgen receptors, but the possibility is there.

I really don't want to argue about anti-androgens. In my experience they all give me side effects, and are tied to hormonal pathways that are just too important for my health and identity as a man to **** with. If you want to roll those dice, go ahead.

My goal is to bring to market an option that has top scientists behind, it, that has PROVEN safety as opposed to RU, and that at least has very strong anecdotal evidence of success at halting loss. Breathlessness is something that every person with anxiety experiences, and neither that or insomnia really scare me, especially if they are mild. The worst that can happen is you get those sides and decide to stop. The worst that can happen on fin is that you get sides and they never go away. I personally know people who this has happened to. For me the choice is simple.

Nope, it can happen with enzymes too a classical example of this is upregulation of cytochrome P450 enzymes. There is zero reasoning to believe that a anti-androgen causes upregulation of AR or AR sensitivity. It could possible but would be the other way around and it would resolve on discontinuation.

Even with beta blockers you are not correct because if they would upregulate that would mean you would to continuously increase your dosage , making the medicine ineffective over a while. Yes you can't abruptly stop from a (high) dosage of them. This is called physical dependence and has nothing to do with upregulation of these receptors; http://en.wikipedia.org/wiki/Physical_dependence. GABA drugs are a primary example of this like alcohol and benzodiazepines

Drugs that cause physical dependence; blood pressure medications, including beta blockers such as propanolol and alpha-adrenergic agonists such as clonidine[18][19]

Top scientists, yeah that's true. But I only see Cotsarelis and Garza being convinced and even Garza acknowledges that many questions marks are to be solved and that possibly PGD2 isn't a major important pathway (http://www.ncbi.nlm.nih.gov/pubmed/24521203).

Nonetheless I'm interested in how everything will unfold regarding this pgd2 angle.