Setipiprant
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Thanks Swoop. Very informative as always. I'd definitely be happy if we had a treatment that stopped further loss hairloss at least as well as fin. I'd go for the HT then and only then. I can't afford to suffer from shock loss and lose more hair. I'm hanging on for dear life right now. I've tried pretty much everything and to be honest, I would probably be in the same position if I hadn't been on RU, minoxidil etc. Nothing has really done anything worth talking about. Recently, my hairloss appears to have stabilised completely. Diffuse as hell all over but it's kind of hit a standstill. The only thing I'm using now is cheap minoxidil from India. I have high hopes for a decent treatment before the end of the decade. If it doesn't happen, I won't be too butt hurt about it. Acceptance is a great thing. Takes a while, but hang in there. Worse things could happen.Comment
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Setipiprant doesn't really handle PGD2 down. It binds to the DP2 receptor (other names CRTH2, GPR44) so that PGD2 can't bind as well to the receptor.
Watch the above picture a few times and you will understand. Please do understand that this isn't confirmed whatsoever, it's just a hypothesis waiting to be tested now.
PGE2 itself is just a prostaglandin just like PGD2. It's already on the market under brand name dinoprostone, a vaginal gel. PGE2 itself also has it's receptor it binds to and activates EP1, EP2, EP3 and EP4.
The pictures should help you understand.
But what I don't understand is whats the best way to possible get PGE2 up right now? Is it dinoprostone? Does Latisse or any other bim product increase PGE2?
We can use seti as the receptor blocker (in theory), whats the best option for upping PGE2?
I too would be happy just maintaining what I have then going for a transplant to fill in the rest. I cannot afford to wait 5-10 yrs though.
I need help now. Now. NOW! NNNNNOOOOOOOWWWWWW!!!! haha sorry bout thatComment
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That does help, thanks a lot swoop. Always good info.
But what I don't understand is whats the best way to possible get PGE2 up right now? Is it dinoprostone? Does Latisse or any other bim product increase PGE2?
We can use seti as the receptor blocker (in theory), whats the best option for upping PGE2?
I too would be happy just maintaining what I have then going for a transplant to fill in the rest. I cannot afford to wait 5-10 yrs though.
I need help now. Now. NOW! NNNNNOOOOOOOWWWWWW!!!! haha sorry bout that
I want a new treatment in 2016, since I counted on having a HT in summer 2016. But chances that it will really happen = close to 0% :[Comment
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The best option would be exogenous PGE2 - dinoprostone. To the best of my understanding, PGE2 is much stronger than PGF2a to begin with, and actually partly degrades into PGF2a after it's done it's job (see the chart above), so you're getting maximum effect. BIM is just straight PGF2a and is weaker, and much more expensive!Comment
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The best option would be exogenous PGE2 - dinoprostone. To the best of my understanding, PGE2 is much stronger than PGF2a to begin with, and actually partly degrades into PGF2a after it's done it's job (see the chart above), so you're getting maximum effect. BIM is just straight PGF2a and is weaker, and much more expensive!Comment
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It's used in much higher doses as a vaginal suppository to help women during childbirth. The doses needed for our purposes are miniscule and are applied topically.Comment
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For example: We(men) can take 1mg of Fin daily. If a woman takes only 0.1mg of Fin, she will die or something.Comment
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Wow. Not sure if you're being serious or not.
"Finasteride 5 mg/day is effective and safe for the treatment of female AGA in postmenopausal women in the absence of clinical or laboratory signs of hyper-androgenism."
The only danger Finasteride poses to women is during pregnancy, because of it's effects on the foetus.Comment
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And where did you read this bullshit? Finasteride is safe for women but not for fetus, and anyway is much less effective for their hairlossComment
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