Setipiprant

[Dench57]

That's massive for millions and millions of people if it can be relied upon to work though. You could confidently commit to a hair transplant if you could count on not losing more.

Yes. This "cure" will be something that's guaranteed to stop hairloss dead in its tracks. I don't understand people starting to treat their hairloss when they're NW4 and whine about there not being hair multiplication or whatever..

[diffuseloser]

Thanks Swoop. Very informative as always. I'd definitely be happy if we had a treatment that stopped further loss hairloss at least as well as fin. I'd go for the HT then and only then. I can't afford to suffer from shock loss and lose more hair. I'm hanging on for dear life right now. I've tried pretty much everything and to be honest, I would probably be in the same position if I hadn't been on RU, minoxidil etc. Nothing has really done anything worth talking about. Recently, my hairloss appears to have stabilised completely. Diffuse as hell all over but it's kind of hit a standstill. The only thing I'm using now is cheap minoxidil from India. I have high hopes for a decent treatment before the end of the decade. If it doesn't happen, I won't be too butt hurt about it. Acceptance is a great thing. Takes a while, but hang in there. Worse things could happen.

[Sogeking]

So we don't know when they start the phase trial or how long it will last?

[hellouser]

So we don't know when they start the phase trial or how long it will last?

Expect delays, as per usual.

[champpy]

Setipiprant doesn't really handle PGD2 down. It binds to the DP2 receptor (other names CRTH2, GPR44) so that PGD2 can't bind as well to the receptor.



Watch the above picture a few times and you will understand. Please do understand that this isn't confirmed whatsoever, it's just a hypothesis waiting to be tested now.

PGE2 itself is just a prostaglandin just like PGD2. It's already on the market under brand name dinoprostone, a vaginal gel. PGE2 itself also has it's receptor it binds to and activates EP1, EP2, EP3 and EP4.




The pictures should help you understand.

That does help, thanks a lot swoop. Always good info.

But what I don't understand is whats the best way to possible get PGE2 up right now? Is it dinoprostone? Does Latisse or any other bim product increase PGE2?

We can use seti as the receptor blocker (in theory), whats the best option for upping PGE2?

I too would be happy just maintaining what I have then going for a transplant to fill in the rest. I cannot afford to wait 5-10 yrs though.
I need help now. Now. NOW! NNNNNOOOOOOOWWWWWW!!!! haha sorry bout that

[chongmet]

That does help, thanks a lot swoop. Always good info.

But what I don't understand is whats the best way to possible get PGE2 up right now? Is it dinoprostone? Does Latisse or any other bim product increase PGE2?

We can use seti as the receptor blocker (in theory), whats the best option for upping PGE2?

I too would be happy just maintaining what I have then going for a transplant to fill in the rest. I cannot afford to wait 5-10 yrs though.
I need help now. Now. NOW! NNNNNOOOOOOOWWWWWW!!!! haha sorry bout that

Yeah we all want it now, but with all that good news lately, we should not forgot that nothing actually happened. And we don't even know if any of these nice stuff works.
I want a new treatment in 2016, since I counted on having a HT in summer 2016. But chances that it will really happen = close to 0% :[

[Dench57]

But what I don't understand is whats the best way to possible get PGE2 up right now? Is it dinoprostone? Does Latisse or any other bim product increase PGE2?

We can use seti as the receptor blocker (in theory), whats the best option for upping PGE2?

The best option would be exogenous PGE2 - dinoprostone. To the best of my understanding, PGE2 is much stronger than PGF2a to begin with, and actually partly degrades into PGF2a after it's done it's job (see the chart above), so you're getting maximum effect. BIM is just straight PGF2a and is weaker, and much more expensive!

[chongmet]

The best option would be exogenous PGE2 - dinoprostone. To the best of my understanding, PGE2 is much stronger than PGF2a to begin with, and actually partly degrades into PGF2a after it's done it's job (see the chart above), so you're getting maximum effect. BIM is just straight PGF2a and is weaker, and much more expensive!

Are you guys sure that messing with pge2 levels is safe? No clinical trials were made on this issue, and nobody knows how safe is to just add pge2, and dosages etc...

[Dench57]

Are you guys sure that messing with pge2 levels is safe? No clinical trials were made on this issue, and nobody knows how safe is to just add pge2, and dosages etc...

It's used in much higher doses as a vaginal suppository to help women during childbirth. The doses needed for our purposes are miniscule and are applied topically.

[chongmet]

It's used in much higher doses as a vaginal suppository to help women during childbirth. The doses needed for our purposes are miniscule and are applied topically.

Comparing our bodies to women bodies when testing safety of different drugs is a critical mistake.
For example: We(men) can take 1mg of Fin daily. If a woman takes only 0.1mg of Fin, she will die or something.

[Dench57]

If a woman takes only 0.1mg of Fin, she will die or something.

Wow. Not sure if you're being serious or not.

"Finasteride 5 mg/day is effective and safe for the treatment of female AGA in postmenopausal women in the absence of clinical or laboratory signs of hyper-androgenism."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746222/

The only danger Finasteride poses to women is during pregnancy, because of it's effects on the foetus.

[Keki]

Comparing our bodies to women bodies when testing safety of different drugs is a critical mistake.
For example: We(men) can take 1mg of Fin daily. If a woman takes only 0.1mg of Fin, she will die or something.

And where did you read this bullshit? Finasteride is safe for women but not for fetus, and anyway is much less effective for their hairloss

[JayM]

Comparing our bodies to women bodies when testing safety of different drugs is a critical mistake.
For example: We(men) can take 1mg of Fin daily. If a woman takes only 0.1mg of Fin, she will die or something.

Has to be a troll post?

[chongmet]

Ok, I didn't realize that you guys are too serious. Anyway, my point was that we can't count on dosages women take in their vaginas in order to estimate dosage we should take ourselves.

AND WHAT ABOUT AN UPDATE FROM GUYS THAT USING SETI?

[bibi]

Don't forget that there is more than 10 Crth2 inhibitor(like OC459) in trial already for asthma.
Asthma is the reason that Crth2 inhibitors will come onto market pretty quickly so I would not be worried that much about pipeline etc.