Setipiprant

[awdtnr91]

What vendor did the group buy go through? How are these guys administering seti? Vehicle? Oral, topical? How much?

[baldybald]

So what is the recommended daily dosage ?

[hellouser]

What vendor did the group buy go through? How are these guys administering seti? Vehicle? Oral, topical? How much?

40mg per 1ml.

[baldybald]

So if I want to take it as a tablet per day, what is the dosage ?

[hellouser]

So if I want to take it as a tablet per day, what is the dosage ?

Nobody knows yet.

[chongmet]

I also like the idea of taking a pill of Seti better.

[hellouser]

I also like the idea of taking a pill of Seti better.

Don't expect shortcuts.

[Dench57]

So if I want to take it as a tablet per day, what is the dosage ?

Since we don't know the effective dose, whatever your wallet will allow. Safety looks excellent on doses of 1000mg daily. Most people are using 100mg-200mg oral daily from what I've seen.

[chongmet]

Don't expect shortcuts.

Well, yep. It is a shortcut. But if Im not mistaken, they took it orally in the trials?

[baldybald]

Yes, 1000nm daily. I think oraly is more effective.

[Dench57]

Yes, 1000nm daily. I think oraly is more effective.

It's unlikely that oral would be more effective considering around 53% gets excreted (wasted) when taken orally. I imagine Kythera are producing it as an oral because it's proven safe and for marketing purposes; everyone would rather pop a pill than pour a topical on their head.

[JayM]

Where are kythera with Seti right now? I've been hearing all about bim but Seti?

[Dench57]

Where are kythera with Seti right now? I've been hearing all about bim but Seti?

http://investors.kythera.com/releasedetail.cfm?ReleaseID=932602

http://www.kythera.com/products/overview/

That top link was published today. I think this means they'll be moving to Phase II trials for efficacy in men with AGA. The safety profile is already well established.

[JayM]

Let's hope that they can move to phase 2 straight away. Thats good news though and it's actually confirmed!

[Swooping]

Yeah phase 2. It has a very good safety profile AFAIK. However what I was wondering is how long the trial is going to take? I mean it's supposed to be a preventative treatment not a regrowth treatment as per the hypothesis of Kythera et al hypothesizing that PGD2 functions upstream after AR activation.



Does anyone know how long the trial is going to be?