Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[It's2014ComeOnAlready]

Let me make this clear to anyone reading this thread: This drug will have NO sexual side effects, NONE. This drug will be more effective than propecia because PGD2 is more causal to hair loss than DHT is. Propecia doesn't even block all DHT, so some PGD2 is still elevated downstreatm in the scalps of men who are using propecia.

IF you want to understand the relationship between DHT and PGD2 look at page 8 of this presentation:http://files.shareholder.com/downloa...0Deck%209FEB15

Enough of the "is it gonna be more effective than propecia? Will it have the sides?" YES IT WILL BE MORE EFFECTIVE. NO, THERE WILL BE NO SEXUAL SIDE EFFECTS because there were none in healthy men and women taking oral doses.

[Parsia]

Let me make this clear to anyone reading this thread: This drug will have NO sexual side effects, NONE. This drug will be more effective than propecia because PGD2 is more causal to hair loss than DHT is. Propecia doesn't even block all DHT, so some PGD2 is still elevated downstreatm in the scalps of men who are using propecia.

IF you want to understand the relationship between DHT and PGD2 look at page 8 of this presentation:http://files.shareholder.com/downloa...0Deck%209FEB15

Enough of the "is it gonna be more effective than propecia? Will it have the sides?" YES IT WILL BE MORE EFFECTIVE. NO, THERE WILL BE NO SEXUAL SIDE EFFECTS because there were none in healthy men and women taking oral doses.

Ok thanks for make it clear to us , would you please tell me when do you think ( estimation ) this product would be available in market?

Should we wait at least 3 years you think?

[Jonathan]

Let me make this clear to anyone reading this thread: This drug will have NO sexual side effects, NONE. This drug will be more effective than propecia because PGD2 is more causal to hair loss than DHT is. Propecia doesn't even block all DHT, so some PGD2 is still elevated downstreatm in the scalps of men who are using propecia.

IF you want to understand the relationship between DHT and PGD2 look at page 8 of this presentation:http://files.shareholder.com/downloa...0Deck%209FEB15

Enough of the "is it gonna be more effective than propecia? Will it have the sides?" YES IT WILL BE MORE EFFECTIVE. NO, THERE WILL BE NO SEXUAL SIDE EFFECTS because there were none in healthy men and women taking oral doses.

Give the CTO at Kythera a call before they start their proof-of-concept trial. Its will be a waste of time and money since you already got all the answers.

[sdsurfin]

why are sexual side effects the only important side effects? It sounds like if a drug turned your face into a goats face but left your libido intact you would still take it happily. I think constant headaches and feeling asleep all the time are just as bad if not worse. Propecia never ****ed up my sex drive too bad, but it did make me feel braindead. your brain is really the thing that matters most.

[It's2014ComeOnAlready]

Give the CTO at Kythera a call before they start their proof-of-concept trial. Its will be a waste of time and money since you already got all the answers.

It would be extremely helpful if you just read the presentation. I'm not saying the drug works, I'm saying that if it does, it would have no sexual side effects, and would theoretically be more effective than propecia. This is also based on years or research and trials. Keep listening to sdsurfin, the fear-mongering denialist. Like the fox news of hair loss message boards.

[bigentries]

I'm not saying the drug works

You are saying that, read your posts more carefully. In your last post you affirmed the drug will work, will not have sexual side effects and will work better than propecia.

Don't you think you are getting too attached? Are you really a 2014 user? You should really read the archives to see how some guys get too attached to any treatment that brought hope

[It's2014ComeOnAlready]

You are saying that, read your posts more carefully. In your last post you affirmed the drug will work, will not have sexual side effects and will work better than propecia.

Don't you think you are getting too attached? Are you really a 2014 user? You should really read the archives to see how some guys get too attached to any treatment that brought hope

They said the drug works in vitro, because they studied it in hair chemical pathways. It does not have sexual side effects because it was tested on hundreds of healthy men and women in an oral form, and there were no reportings. Theoretically, it will be more effective than finasteride because PGD2 is further downstream of DHT. Finasteride doesn't block all DHT, and therefore doesn't block the creation of excess PGD2.

I've been posting on this forum since 2014, but have been reading for much longer.

[hellouser]

They said the drug works in vitro, because they studied it in hair chemical pathways. It does not have sexual side effects because it was tested on hundreds of healthy men and women in an oral form, and there were no reportings. Theoretically, it will be more effective than finasteride because PGD2 is further downstream of DHT. Finasteride doesn't block all DHT, and therefore doesn't block the creation of excess PGD2.

I've been posting on this forum since 2014, but have been reading for much longer.

Finasteride along with Setipiprant and Minox should yield some impressive results. I wonder what we can get in combination with Histogen/Replicel should either of them come to fruition.

[sdsurfin]

They said the drug works in vitro, because they studied it in hair chemical pathways. It does not have sexual side effects because it was tested on hundreds of healthy men and women in an oral form, and there were no reportings. Theoretically, it will be more effective than finasteride because PGD2 is further downstream of DHT. Finasteride doesn't block all DHT, and therefore doesn't block the creation of excess PGD2.

I've been posting on this forum since 2014, but have been reading for much longer.

In vitro is not the same as in vivo. Also, PGD2 is not the only cause of hairloss. You have no idea how it works compared to propecia, nor do they really. blocking DHT is actually potentially more effective BECAUSE it is upstream, and blocks any and all interactions that are downstream. By blocking PGD2, you are only blocking one of the things that DHT unleashes. My personal informed take is that this will be quite effective at stopping hair loss (basing this on trials of very similar compounds run by forum users, and by the way that this pathway works). I don't think much regrowth will occur. Combining with another drug might be very good for stopping hairloss and gaining back hair, but the question becomes how many and how severe are the side effects form one or both of these drugs. From the safety trials I'm not too optimistic, and trust me I would like to be. But 25% of people getting headaches is a lot of side effects, and if the drug is this potent an antihistamine, I'm almost positive it won't be great for you long term. Again, I could be wrong. This is going to have to be tested long term with dosing trials. I think the best thing we can take from this is that someone researched hair loss, and a company acted on it. first time in history.

[It's2014ComeOnAlready]

In vitro is not the same as in vivo. Also, PGD2 is not the only cause of hairloss. You have no idea how it works compared to propecia, nor do they really. blocking DHT is actually potentially more effective BECAUSE it is upstream, and blocks any and all interactions that are downstream. By blocking PGD2, you are only blocking one of the things that DHT unleashes. My personal informed take is that this will be quite effective at stopping hair loss (basing this on trials of very similar compounds run by forum users, and by the way that this pathway works). I don't think much regrowth will occur. Combining with another drug might be very good for stopping hairloss and gaining back hair, but the question becomes how many and how severe are the side effects form one or both of these drugs. From the safety trials I'm not too optimistic, and trust me I would like to be. But 25% of people getting headaches is a lot of side effects, and if the drug is this potent an antihistamine, I'm almost positive it won't be great for you long term. Again, I could be wrong. This is going to have to be tested long term with dosing trials. I think the best thing we can take from this is that someone researched hair loss, and a company acted on it. first time in history.

You are spewing utter nonsense. I'm done responding to you.

[sdsurfin]

You are spewing utter nonsense. I'm done responding to you.

You're a moron. People can decide for themselves if what I'm saying is nonsense. My father is a dermatologist and I'm a biology major. None of what I'm saying is anything more than informed and knowledgeable speculation. I hope I'm wrong, I really do. Even if I'm right I'm sure there will be lucky people who can use this without consequence, there always are. I've tried contacting these guys to no avail. Best bet would be for someone in cali to make an appointment to see the head of research who is a dermatologist.

[Illusion]

Meh gotta side with sdsurfin on this one I guess. I'm glad that we're moving forward and I'm not going to make any guesses/assumptions about its efficacy and sides. But IF it could give the same sides like antihistamines (sleepinness, drowsiness and headaches) then that's a pitty really. Ofcourse it's to each his own to say "I'd prefer x side over y side" but personally, I think being sleepy most of the time and having frequent headaches will drastically decrease the quality of ones life. But we will see, let's wait for the trials first.


@sdsurfin, you were talking about the withdrawal effect of antihistamines but the withdrawal effect in itself shouldn't be that much of a problem right? I don't know how frequently we have to apply this, but if we would have to apply this every day for the rest of our lives, then we wouldn't ever have a withdrawal effect right?

But there are obv the sides, which could suck. I've read about that drowsiness caused by antihistamines before and it didn't seem like it was something you could come to terms with and live with the rest of your life

[sdsurfin]

Meh gotta side with sdsurfin on this one I guess. I'm glad that we're moving forward and I'm not going to make any guesses/assumptions about its efficacy and sides. But IF it could give the same sides like antihistamines (sleepinness, drowsiness and headaches) then that's a pitty really. Ofcourse it's to each his own to say "I'd prefer x side over y side" but personally, I think being sleepy most of the time and having frequent headaches will drastically decrease the quality of ones life. But we will see, let's wait for the trials first.


@sdsurfin, you were talking about the withdrawal effect of antihistamines but the withdrawal effect in itself shouldn't be that much of a problem right? I don't know how frequently we have to apply this, but if we would have to apply this every day for the rest of our lives, then we wouldn't ever have a withdrawal effect right?

But there are obv the sides, which could suck. I've read about that drowsiness caused by antihistamines before and it didn't seem like it was something you could come to terms with and live with the rest of your life

Well the problem is that with things like zyrtec, they often lose their effectiveness over time. To keep having the same effect you have to take more and more, and that can be damaging to your body, not to mention with higher doses you get more sides. Then when people try to quit they go through major withdrawals. The problem is that the receptor that you are blocking is not just used in your body for hair, just like 5ar enzyme has many purposes besides killing hair. The good thing is that if you can tough the withdrawal out you might not be permanently affected, as happens with some propecia users. Could maybe take this for ten years and then go through a really shitty month or so of quitting. It's less of a risk to take than permanently killing your dick. Hopefully withdrawals from this would be rare (and i think topical applications are usually less absorbed as a whole, despite naysayers), and hopefully the side effects are tolerable. Really I'm more scared that it will be a great drug but that most of us won't be able to use it. I can't even use minox because it gives me awful raccoon bags under my eyes, and if 25 percent of people are getting headaches and sleepiness from Pip (I'm officially abbreviating setipiprant to pip cause that shit is hard to type and remember) then it doesn't bode well for many of us. Keep your fingers crossed. Replicel is in phase 2, so you might have a better option by the time this comes out anyway.

[HairlossAt15]

Lmao cotsaerlis spells out in his studies how big of a impact pgd2 has on hair growth. Then the Kythera presentation translates it into laymen terms. Human hairs grows as normal when pgd2 effect is removed, simple as that.

Headaches are normal side effects in any trial... Probably just placebo effect from paranoid testers...

[Gerhard]

You are spewing utter nonsense. I'm done responding to you.

2014, we're all as hopeful and as excited as you on the development of this drug. However, you need to accept that sdsurfin has made some valid and very real points. While we may not want to hear them, they are possibilities that must be considered, weighed, and remind ourselves of. Not everything is perfect. His points on the effects of prolonged antihistamine usage is valid. Be respectful, please. We're all brothers in the hairloss boat.

You're a moron. People can decide for themselves if what I'm saying is nonsense. My father is a dermatologist and I'm a biology major. None of what I'm saying is anything more than informed and knowledgeable speculation. I hope I'm wrong, I really do. Even if I'm right I'm sure there will be lucky people who can use this without consequence, there always are. I've tried contacting these guys to no avail. Best bet would be for someone in cali to make an appointment to see the head of research who is a dermatologist.

Remember, we're all brothers in this. No need to be name calling and such. We're all old enough to avoid that. I think your points are valid and useful and I'm happy that you've presented them. Whether it's good or bad news all news is important to gauge the possible efficacy of these future treatments and if we have reason to be wary or concerned.