Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[Hairismylife]

According to to shareholders info:
During 2015/16
- Open an IND for sepiprant
- Initiate a Proof-of-Concept study for sepiprant

...It will take time before it hits the stores so lets find a way to get hold of sepiprant and make our own proof-of-concept instead of whining about how long everything takes and that no one cares. Now we actually have a chance to do something ourselves. The product has been tested to be safe, so what are we waiting for? It could be as simple as this:

1. We find one dedicated member that can organize this (PM)
2. Every one in here helps to vacuum the internet to find the best source that can provide sepiprant.
3. When the source is validated by the most knowledgeable members in here, maybe we even can lab test the drug to make sure its legit.
4. PM is collecting money and info regarding age,sex,current regimes etc from users who want to participate in this study and buys a big stock of sepiprant.
5. PM is distributing sepiprant to the participants and collects weekly photos from them and publish them on a web page in an organized way (participants only get the drug if he/she provides photos). If we get many participants we could even try different strengths etc without telling the participant (but no placebo for sure)

...then 6 months from now we know if its working or not!. I would not mind taking the PM role if i am trusted, but I live in Sweden and that is maybe not optimal place distribution wise. I think its important that all participants use same source and that we have one guy in the middle that organizes it, so not everyone is doing it their own way and it end up as usual with 100 diverting result that you don't know what to trust.

Let me know if any one else thinks this is a good idea.

Count me in. But what means by IND?

[Jonathan]

According to to shareholders info:
During 2015/16
- Open an IND for sepiprant
- Initiate a Proof-of-Concept study for sepiprant

...It will take time before it hits the stores so lets find a way to get hold of sepiprant and make our own proof-of-concept instead of whining about how long everything takes and that no one cares. Now we actually have a chance to do something ourselves. The product has been tested to be safe, so what are we waiting for? It could be as simple as this:

1. We find one dedicated member that can organize this (PM)
2. Every one in here helps to vacuum the internet to find the best source that can provide sepiprant.
3. When the source is validated by the most knowledgeable members in here, maybe we even can lab test the drug to make sure its legit.
4. PM is collecting money and info regarding age,sex,current regimes etc from users who want to participate in this study and buys a big stock of sepiprant.
5. PM is distributing sepiprant to the participants and collects weekly photos from them and publish them on a web page in an organized way (participants only get the drug if he/she provides photos). If we get many participants we could even try different strengths etc without telling the participant (but no placebo for sure)

...then 6 months from now we know if its working or not!. I would not mind taking the PM role if i am trusted, but I live in Sweden and that is maybe not optimal place distribution wise. I think its important that all participants use same source and that we have one guy in the middle that organizes it, so not everyone is doing it their own way and it end up as usual with 100 diverting result that you don't know what to trust.

Let me know if any one else thinks this is a good idea.

[walrus]

I'm skeptical of replicel but still cautiously hopeful that it might be a long term fix.

Even if things like replicel work, you will still probably need something like this to normalise prostaglandin levels in the scalp and avoid going back to square one.

[HairlossAt15]

Most important part:




Hairs grows as normal when PGD2 blocked, this is human hair!

[sdsurfin]

This is a comment from two years ago on another forum just goes to show how crowdsourced info is always ahead of the curve these days. I'm pretty positive this drug is going to have some efficacy, especially and maintaining hair, but also pretty sure the side effects are not gonna be fun. This is not baseless speculation, look online for what people say about cetrizine or other similar compounds. Drowsiness and headaches are big time, and both came up in the clinical trials for this drug too. Still, might be worth taking until someone comes out with a cell based treatment.



"TaKeeLa

23.03.2012, 12:14

@ TaKeeLa
PGD2 RECEPTOR 2 ANTAGONIST (BLOCKER)
» These aren't the same receptors? You are saying DP2 and CRTH2 not PGD2??

I think this is what you are looking for....

Setipiprant by Actelion blocks the right PGD2 receptor implicated in MPB (PD2). Right now, setipiprant is in phase 2/3 testing. "

[sdsurfin]

http://files.shareholder.com/downloa...0Deck%209FEB15[1].pdf


that's the link. look it up yourself.

[sdsurfin]

I read it. I'm pretty sure you're not getting the context. It's saying that Setipiprant is in it's current form, a selective oral antagonist of pgd2. We know that. The press release does not mention in which form it will be delivered. Do you get the difference?

Cotsarelis' numerous suggestions that it would be delivered topically is still a possibility, because we don't know yet how it will be applied.

I meant the investors release. not the press release. The press release doesn't say anything but the other one does. It specifically says it its oral. Also, DanWS this has nothing to do with follica other than the fact that cotsarellis is involved with both things. This will not involve wounding or topicals or any of that. These guys are working on different things at once. Actually the fact that they have sold off the rights to the PGD2 research only makes it clearer that the whole wounding thing has probably been abandoned. Cotsarellis' research on PGD2 action is what has been purchased by kythera, not follica or that line of inquiry.

[DanWS]

Cotsarelis' numerous suggestions that it would be delivered topically is still a possibility, because we don't know yet how it will be applied.

On the technology platform Follica are reported to be using...

Like most baldness procedures it sounds mildly terrifying: they start with a process called 'skin-peturbation' where the top layers of the scalp are peeled back. The cells beneath then revert to a stem-cell like state, and a topical solution is applied to the area that re-boots the cells to start producing hair.

http://www.huffingtonpost.co.uk/2013/09/09/baldness-cure-prevention-follica-_n_3892684.html

[It's2014ComeOnAlready]

Read the press release. It's oral.

I read it. I'm pretty sure you're not getting the context. It's saying that Setipiprant is in it's current form, a selective oral antagonist of pgd2. We know that. The press release does not mention in which form it will be delivered. Do you get the difference?

Cotsarelis' numerous suggestions that it would be delivered topically is still a possibility, because we don't know yet how it will be applied.

[sdsurfin]

Read the press release. It's oral.

[sdsurfin]

Everything about this news seems to have gone completely over your head. This is all of Follica and Cotsarelis' work with pgd2 about to go into a trial. Could be just one trial because 3 safety trials were already completed in both men and women (and 8 trials total), the only thing they haven't done is test their topical formulation. You are off jabbering about nothing.

Do you read anything? The press release from Kythera states very clearly that they will test this as an oral formulation. Nothing about topicals. Also, they very clearly posted their side effects in their clinical studies. I am not saying this is useless. Other PGD2 blockers have already proven to completely halt hair loss. However, even the scientists do not have the testing knowledge that online users do. This is a different compound, which is good, but it is very similar, and probably has similar side effects. Prolonged users of cetrizine report very bad withdrawals with itching and headaches when they go off the drug. I'm guessing the same will happen with this one after prolonged oral usage, though I can't be certain obviously. I'm still encouraged that new info on hair loss is being put to use, and I plan to go on topical cetrizine immediately.

Also there is no reason to think that clinical trials will not be done as a separate thing for hair loss. Im sure they will test the efficacy and dosage in prolonged trips before they spend the money to market this for AA.

[It's2014ComeOnAlready]

Perhaps I read it wrong, but I thought they were going to go with an oral formula. Was I incorrect in that?

I don't believe it listed the delivery or the type of vehicle. I just assumed it was topical because Cots said all along it would be topical. Plus oral doses have already gone through trials with healthy adult men and women.

[Gerhard]

Everything about this news seems to have gone completely over your head. This is all of Follica and Cotsarelis' work with pgd2 about to go into a trial. Could be just one trial because 3 safety trials were already completed in both men and women (and 8 trials total), the only thing they haven't done is test their topical formulation. You are off jabbering about nothing.

Perhaps I read it wrong, but I thought they were going to go with an oral formula. Was I incorrect in that?

[It's2014ComeOnAlready]

No sex is terrible, and I have felt firsthand propecia's effect on the brain.

I do have to correct my previous post, because I've been reading about other PGD2 blockers, and people seem to have maintained their hair completely while on them (search cetrizine). So as a maintenance technique I think this actually has a lot of promise. Not sure it will regrow anything, and I'm not sure if kerythea knows that either after reading their press release.

The side effects do scare me, there are several posters on the cetrizine thread that talk about withdrawal effects (severe itching, massive headaches) after stopping oral use of cterizine after prolonged use. I think I will probably hop on the cetrizine train though for now, I can't take propecia or minox and maybe if I can hold on to what I've got for a few years something better will come along. I'm skeptical of replicel but still cautiously hopeful that it might be a long term fix.

Everything about this news seems to have gone completely over your head. This is all of Follica and Cotsarelis' work with pgd2 about to go into a trial. Could be just one trial because 3 safety trials were already completed in both men and women (and 8 trials total), the only thing they haven't done is test their topical formulation. You are off jabbering about nothing.

[sdsurfin]

No sex is terrible, and I have felt firsthand propecia's effect on the brain.

I do have to correct my previous post, because I've been reading about other PGD2 blockers, and people seem to have maintained their hair completely while on them (search cetrizine). So as a maintenance technique I think this actually has a lot of promise. Not sure it will regrow anything, and I'm not sure if kerythea knows that either after reading their press release.

The side effects do scare me, there are several posters on the cetrizine thread that talk about withdrawal effects (severe itching, massive headaches) after stopping oral use of cterizine after prolonged use. I think I will probably hop on the cetrizine train though for now, I can't take propecia or minox and maybe if I can hold on to what I've got for a few years something better will come along. I'm skeptical of replicel but still cautiously hopeful that it might be a long term fix.