Dkk1 Stimulate Hair Follicles For Hair Growth When They Appear Dead

[Swooping]

I just did put the question to Dr. Gardner. The way I put it to Gardner is "What if inhibition of DKK1 is only half of the equation and the other half of the equation is to add growth factors?"

Keep in mind that in all hair loss treatments we have seen so far the best results come when we work on both sides of the equation - negating what causes hair loss, and adding what prompts hair growth. Both. In the case of minoxidil (a hair growth stimulant) it works better when you add propecia, which negates the dht that inhibits hair growth. So when you use minoxidil and propecia you are working on both sides of the equation. If you look at what Cotseralis said about prostaglandins, he said you would negate PGD2 (which inhibits hair growth) and you would increase PGE2 (a hair growth stimulant). So in the prostaglandin model you work both sides of the equation. In other words, perhaps in the growth factor model you also have to work both sides of the equation. You have to add growth factors that stimulate hair growth and you have to negate the one factor that inhibits hair growth - DK11.

Isn't this plausible?

We spoke about DKK-1 here, and no that won't regrow hair on its own yourroyalhairness. Adding in those growth factors from the FGF family, SHH family, WNT etc will grow some hair. That is what histogen is doing. There is a distinct difference in growing some hair and completely curing a nw6 where DNA damage is done and the cell's cant repair itself and lack profileration. You do increase your chances indeed in using multiple agents like anti pgd2, minoxidil, retin-a, hydrocortisone or beta, growth factors, dut, ru etc. I did regrow my hair from nw4 to nw 1.5 now with temporal regrowth using this approach. Cause my cells still probably had the capacity to regenerate. Anyways good question, let's see what Aaron Gardner says. I would like to get a bit more in depth with him on it so I'll keep an eye on it.

[nameless]

Not short term indeed. Eventually it will come though, meanwhile do all you can to stop and regrow your hair.

Nameless aka jarjar please maybe ask your beloved nigam how he did his frankenstein experiments with even DKK1 antagonists. How many hair did he grow again? Ohw yeah 60k!! (in photoshop lol!!). . Case closed.

Swooping, what DKK1 antagonist did Dr. Nigam use? At what concentration? How much did he use? How did he get the DKK1 antagonist into the target area? How many times did he get the DKK1 antagonist into the same patient?
What was the frequency?

[Thinning87]

Not short term indeed. Eventually it will come though, meanwhile do all you can to stop and regrow your hair.

Nameless aka jarjar please maybe ask your beloved nigam how he did his frankenstein experiments with even DKK1 antagonists. How many hair did he grow again? Ohw yeah 60k!! (in photoshop lol!!). . Case closed.

Ha!

(What should be closed is your mouth)

[Swooping]

Really, it's demotivating to know that nothing new will come out.

Not short term indeed. Eventually it will come though, meanwhile do all you can to stop and regrow your hair.

Nameless aka jarjar please maybe ask your beloved nigam how he did his frankenstein experiments with even DKK1 antagonists. How many hair did he grow again? Ohw yeah 60k!! (in photoshop lol!!). . Case closed.

[Thinning87]

Thank you.

And I will stop being an asshole to the casual poster who spreads negative rumors based on their feelings and based on "they always say five years away" when the same casual poster will have the decency not to act like a smart ass

[beetee]

thinning shut the **** up

swooping knows WAY more about this shit than you do. stop being ****ing delusional this treatment has NO proof of being effective and I am tired of people like you hyping up god damn theories over and over.

this forum is falling the fck apart. if ANY of you guys are refraining from taking fin/dut/ru/minox/niz because you think these fcking articles somehow suggest we're less than 5 years away from something better than what we have then prepare to be very disappointed and to lose a lot of hair. i've been following this website since 2009 and guess how many effective treatments have come out? NONE. out of dozens and dozens of studies like this, not one treatment.

I would guess that very few if any people are not using the treatments that you mention because they think some other treatment is right around the corner. There are many legitimate reasons not to use the treatments you mention, primarily because for many they barely work, if at all. That being said, if anyone does not have an open mind as to the possibility that a treatment could be developed, I wonder why they would be spending any time on the "cutting edge/future treatments" thread (?).

Different posters on here have different levels of knowledge about what's in the works, but I don't think anyone can speak with any real authority about what will or will not work. If anyone thinks they can, you should submit proof of your singularly advanced understanding of the biology, chemistry, and genetics involved in hair loss and hair regrowth to some of these companies that are spending millions of dollars and using thousands of man hours of people that have spent many years in advanced studying and training to conduct research and tests in the hopes of finding something that might work. You could save them a lot of time and money and they'll cut you in some stock options, and you'll undoubtedly make tens of millions of dollars in the process.

[JulioGP]

Really, it's demotivating to know that nothing new will come out.

[nameless]

thinning shut the **** up

swooping knows WAY more about this shit than you do. stop being ****ing delusional this treatment has NO proof of being effective and I am tired of people like you hyping up god damn theories over and over.

this forum is falling the fck apart. if ANY of you guys are refraining from taking fin/dut/ru/minox/niz because you think these fcking articles somehow suggest we're less than 5 years away from something better than what we have then prepare to be very disappointed and to lose a lot of hair. i've been following this website since 2009 and guess how many effective treatments have come out? NONE. out of dozens and dozens of studies like this, not one treatment.

Conpecia you're wrong.

Thinning's point is WAY stronger than Swooping's point. It has definitely not been proved that the DKK1 pathway does not matter. Thinning is right about that. But I do admit that Thinning should not disrespect Swooping. And I think that Thinning being rude to Swooping is causing other posters not to see the validitiy of Thinning's basic point about what has and hasn't been proved. Thinning is definitely right although he shouldn't be mean about it.

[nameless]

Swooping = wrong on facts/science

Thinning = right on facts/science

Thinning = wrong on being too mean.

We are all in this nightmare together. We should try to work together. We have enough trouble from people with full heads of hair hating on us so we should not be hating on each other.

[Conpecia]

thinning shut the **** up

swooping knows WAY more about this shit than you do. stop being ****ing delusional this treatment has NO proof of being effective and I am tired of people like you hyping up god damn theories over and over.

this forum is falling the fck apart. if ANY of you guys are refraining from taking fin/dut/ru/minox/niz because you think these fcking articles somehow suggest we're less than 5 years away from something better than what we have then prepare to be very disappointed and to lose a lot of hair. i've been following this website since 2009 and guess how many effective treatments have come out? NONE. out of dozens and dozens of studies like this, not one treatment.

[nameless]

**** you. He made a comment about Cotsarelis's presentation admitting he hadn't even seen it. The comment he made implied they can't make any progress based on the fact that scientists always say everything is five years away, and what supposedly Cotsarelis intended or did not intend when speaking to Desmond. I pointed this out and got the smart ass reply. Again, the guy had t even seen the damn video. Like I said, go **** yourself.

Thinning really, you're right on the scientific issue but there is really no reason to get so mad and be so mean about it. You're hurting your own position because when you post so mean it makes others disagree with you on a personal leven and then they don't see the correctness of your point.

[nameless]

Really Thinning87 stop being an ass and making a complete fool of yourself. You practically started all this nonsense because you couldn't find a coherent way of disagreeing with someone else and just resorted to name-calling. What's ironic that this IS a forum about hairloss, so astonishingly people may actually post pictures of themselves and their hair. What's even more ironic is that you actually asked him to see a pictures of his hair, and after doing so you make up another insult. Seriously get your mood-swings checked and come back to the forum when you have something useful to say.

I totally agree that Thinning's insults were undeserved and he shouldn't have insulted Swooping, but I disagree with your insinuation that he didn't say anything useful in his posts. In between posting insults he did post a counter-argument to Swooping's position and I think thinning's posit is much stronger than Swoopings. I think Thinning has a valid point when he states that Swooping has not proved that DKK1 does not aid in the fight against hair loss. I also do not think that's been proved. I think that Swooping is jumping the gun about that and I think that Thinning really way got the best of Thinning in that debate, although I also think that Thinning shouldn't be rude to Swooping. Swooping is a smart caring guy and even if he is wrong on the issue he and Thinning were debating about we are all wrong sometimes and Thinning should respect him.

[Thinning87]

Really Thinning87 stop being an ass and making a complete fool of yourself. You practically started all this nonsense because you couldn't find a coherent way of disagreeing with someone else and just resorted to name-calling. What's ironic that this IS a forum about hairloss, so astonishingly people may actually post pictures of themselves and their hair. What's even more ironic is that you actually asked him to see a pictures of his hair, and after doing so you make up another insult. Seriously get your mood-swings checked and come back to the forum when you have something useful to say.

**** you. He made a comment about Cotsarelis's presentation admitting he hadn't even seen it. The comment he made implied they can't make any progress based on the fact that scientists always say everything is five years away, and what supposedly Cotsarelis intended or did not intend when speaking to Desmond. I pointed this out and got the smart ass reply. Again, the guy had t even seen the damn video. Like I said, go **** yourself.

[Swooping]

I haven't read it but it's obvious that if they haven't succeeded yet they cannot succeed ever. You really hope they can do this?? Hahaha keep hoping you fool

Dude stop using the cocaine mate or whatever you are on. I said that DKK1 topically doesn't work or internally won't work given the fact of the clinical trials done in cancer and that it has been used already (for hair regrowth). I also said Cotsarelis has never managed to induce de-novo neogenesis and i still stand by that. If you understand what he tries to do and you read the hint i gave you, you'll understand why. There is a distinct difference in regrowing hair or inducing de-novo neogenesis. Follica is trying to achieve the latter.

I have never seen any clinical trial or any medicine in clinical trials in inducing WNT pathway directly so I am highly surprised they are actually starting with it. Do I believe it will grow hair? Maybe, because it has never been done before. Will it induce de-novo with wounding? Nope. God you made my day so hard <3.

[Haircure]

That's what we were doing before you spammed the thread with a comment about a video you haven't even watched: "I haven't seen the video, but it can't be done and the fact that it hasn't been done yet proves it".

Really Thinning87 stop being an ass and making a complete fool of yourself. You practically started all this nonsense because you couldn't find a coherent way of disagreeing with someone else and just resorted to name-calling. What's ironic that this IS a forum about hairloss, so astonishingly people may actually post pictures of themselves and their hair. What's even more ironic is that you actually asked him to see a pictures of his hair, and after doing so you make up another insult. Seriously get your mood-swings checked and come back to the forum when you have something useful to say.