Cotsarelis Presentation - PGD2 inhibition was reversed with blocker

[Swooping]

I honestly don't know, but neither do you. So you don't think that blocking GPR44 receptor would benefit hair growth, and this is based on what? Because you don't have any information at your fingertips? C'mon.

There is to much evidence for it not working indeed. If "any" compound is going to cure AGA in a clinical trial not hair related it's going to be all over the news, never will that be able to kept secret. If it won't go official it will go through the people involved in the clinical trials etc. Considering that many GPR44 compounds have/are in clinical trials we can indeed draw a conclusion that it is not the cure we are hoping for.

That's the advantage of AGA anyway, because relatively many people are suffering from it to some extent and there are clinical trials running constantly we'll know immediately if something miraculously will grow hair. This considering that every clinical trial has people in it with AGA to some extent.

[It's2014ComeOnAlready]

There is to much evidence for it not working indeed. If "any" compound is going to cure AGA in a clinical trial not hair related it's going to be all over the news, never will that be able to kept secret. If it won't go official it will go through the people involved in the clinical trials etc. Considering that many GPR44 compounds have/are in clinical trials we can indeed draw a conclusion that it is not the cure we are hoping for.

So you're still basing this assumption that because we don't have any news on it, it doesn't work. What I do know is that Cots and his team have been standing by this theory as recently as 2014. If you saw my earlier post about their patent inhibiting pgd2 in 2008, which means they've been sticking to their guns for over 6 years. I guess their reputations as scientists/doctors don't mean jack to you because you didn't a news clip of an asthma medication benefitting people with hair loss in trials.

It comes down to that you refuse to believe there's anything going on because you're not getting the piece of news you want. They proved that PGD2 causes AGA, and with all their research, found the right receptor to block.

[It's2014ComeOnAlready]

Why I am even going back and forth with you? They proved that PGD2 inhibition was reversed with a blocker in the video

[Swooping]

So you're still basing this assumption that because we don't have any news on it, it doesn't work. What I do know is that Cots and his team have been standing by this theory as recently as 2014. If you saw my earlier post about their patent inhibiting pgd2 in 2008, which means they've been sticking to their guns for over 6 years. I guess their reputations as scientists/doctors don't mean jack to you because you didn't a news clip of an asthma medication benefitting people with hair loss in trials.

It comes down to that you refuse to believe there's anything going on because you're not getting the piece of news you want. They proved that PGD2 causes AGA, and with all their research, found the right receptor to block.

Look, there are hundreds of people in the clinical trials involved of GPR44 blockers. There is 99% chance that someone or more people in these clinical trials is suffering from AGA to an extent. If it would work, it would show up as an "side-effect" and you would already hear from it. Simple as that. You would definitely hear from it too, no way that that could be kept secretive especially with the information system we have going on globally.

Secondly, I don't know if you are aware but there are people who have tried OC459 and it definitely did not provide substantial results. Not even that, there are pathways upstream of PGD2 like COX-2 etc. There have been many medicines altering these signalling cascades which (indirectly) change PGD2 levels.

And they definitely didn't proof that PGD2 causes AGA, that is just your interpretation.

[It's2014ComeOnAlready]

Agree to disagree. They were able to give a mouse AGA by increasing PGD2 production, and there have been papers published by Garza which basically say yes, it's PGD2.

[35YrsAfter]

DHT - PGD2 - The One Two Punch

DHT and PGD2 are like a "one-two punch". My take is, DHT reduces the fatty layer that Valerie Horsley (Yale Hair Study) cited as necessary for signaling an adequate release of blood platelet growth factors. The lack of growth factors, sends the hair into telogen where it gets the "two" punch from prostaglandin D2. I believe, PGD2 plays a role in apoptosis which is a normal part of the hair cycle. Cotsarelis believes in MPB, the hair cycles are out of balance tipping heavily toward telogen.

So if hair were a lawn, a lack of sufficient platelet growth factors would be like grass not getting enough nitrogen, phosphorus, or potassium. PGD2 in the case of a lawn would be like spraying the lawn with Monsanto's Roundup (glyphosate) after starving the lawn of necessary nutrients.

Some doctors claim that the immune system comes into play once the follicles are thoroughly hammered with PGD2 and treat the dying follicles like a foreign body.

[noisette]

Maybe I don't understand well this news but I see the end of project of Cotsarelis will be on 2018

source: https://grantome.com/grant/NIH/R01-AR055309-07

[hellouser]

Maybe I don't understand well this news but I see the end of project of Cotsarelis will be on 2018

source: https://grantome.com/grant/NIH/R01-AR055309-07

HOW did you find that?! Thank you!

[It's2014ComeOnAlready]

Maybe I don't understand well this news but I see the end of project of Cotsarelis will be on 2018

source: https://grantome.com/grant/NIH/R01-AR055309-07

Nice find! I wish I had the ability to hack follica just too see what's going on. Would ease a lot of anxiety.

[hellouser]

Nice find! I wish I had the ability to hack follica just too see what's going on. Would ease a lot of anxiety.

You'd have to break into their labs. You wont find anything on their server.

[noisette]

Lol You're welcome bro !

[noisette]

HOW did you find that?! Thank you!

I'm a lucky man for our community héhéhé

[noisette]

You'd have to break into their labs. You wont find anything on their server.

ANd take some test tubes, results with you lol

[hellouser]

ANd take some test tubes, results with you lol

I'd take all the binders and pull out all the hard drives from the computers in the labs.

Gold mine.

[It's2014ComeOnAlready]

ANd take some test tubes, results with you lol

I would just like to know if they have a topical that works and when we can expect it. Don't know why it's important for them to keep EVERYTHING under wraps. I would no longer be on these forums, or on fin and give a crap about hair loss because I wouldn't have to.

Such bloody nonsense all of this is.