Cotsarelis Presentation - PGD2 inhibition was reversed with blocker

[It's2014ComeOnAlready]

But they have no product for hairloss in their pipeline lol...

http://puretechventures.com/pipeline.php

Hard to believe that's true with their pgd2 discovery and list of available drugs that block that receptor. Guess you missed my point about follica NOT trying to make billions.

[It's2014ComeOnAlready]

Possibly because Kane's OC000459 could be bunk.

Hellouser - what's your take on follica's progress or where they might be? You seem to be a well-informed and logical person.

[sdsurfin]

http://puretechventures.com/pipeline.php

Hard to believe that's true with their pgd2 discovery and list of available drugs that block that receptor. Guess you missed my point about follica NOT trying to make billions.

Even if you're doing preliminary research, clinical trials always have to be posted. And they take time. Just because Pgd2 blocking aids in hair growth doesn't mean its effective on its own. It's just one of many channels. I doubt cotsarellis was bluffing at the congress, and garza his cohort also said that they have not found the right chemical yet. You broscientists make this all sound like its a simple puzzle. You're not gonna solve it, trust.

That being said, Bimatoprost does work on the pgd3 channel and seems to be at least somewhat effective, so hopefully in the future more will come of this knowledge. My guess is cloned follicles will come before any great chemical or wounding based cure, will be more effective, and will make more money for the HT doctors.

[It's2014ComeOnAlready]

Even if you're doing preliminary research, clinical trials always have to be posted. And they take time. Just because Pgd2 blocking aids in hair growth doesn't mean its effective on its own. It's just one of many channels. I doubt cotsarellis was bluffing at the congress, and garza his cohort also said that they have not found the right chemical yet. You broscientists make this all sound like its a simple puzzle. You're not gonna solve it, trust.

That being said, Bimatoprost does work on the pgd3 channel and seems to be at least somewhat effective, so hopefully in the future more will come of this knowledge. My guess is cloned follicles will come before any great chemical or wounding based cure, will be more effective, and will make more money for the HT doctors.

Not a broscientist. I roll my eyes anytime I see someone on here believe they've solved hair loss with a new method they developed in their basement. It's just extremely hard to believe that they're not working on something or that they haven't gotten anywhere with all the science, and hype that goes with their discovery.

[hellouser]

Hellouser - what's your take on follica's progress or where they might be? You seem to be a well-informed and logical person.

No take, really. IMO, its all in limbo. They've been really silent. Think of it this way:

People criticize Replicel for parading around David Hall and marketing the product all over the world with presentations of a working treatment (even if not very good). People also criticize Follica for NOT being vocal at all. People also criticize Dr. Lauster for not saying ANYTHING AT ALL since his 3D culturing of cells from follicles nearly 5 years ago (which ive been pissed about). People complain about Histogen HAVING a good treatment but not being vocal enough eventhough they're fairly OK with announcements despite issues with funding, etc.

It's be pretty crazy to make a final judgement on the state of Follica... just over a year ago they said they can grow new follicles. Alright... so now do we shrug that off as a lie?

[FearTheLoss]

Even if you're doing preliminary research, clinical trials always have to be posted. And they take time. Just because Pgd2 blocking aids in hair growth doesn't mean its effective on its own. It's just one of many channels. I doubt cotsarellis was bluffing at the congress, and garza his cohort also said that they have not found the right chemical yet. You broscientists make this all sound like its a simple puzzle. You're not gonna solve it, trust.

That being said, Bimatoprost does work on the pgd3 channel and seems to be at least somewhat effective, so hopefully in the future more will come of this knowledge. My guess is cloned follicles will come before any great chemical or wounding based cure, will be more effective, and will make more money for the HT doctors.

I really feel we are all in for some great news this summer when Dr. Wesley finished his regeneration trial. All the science is there for it to work. Mark my words.
I also believe prp is actually going to be the next most effective treatment from results doctors are getting with improvements in their formulas.

[Hairismylife]

Maybe the key to cure MPB is to combat against BOTH dht and pgd2.

[hellouser]

Maybe the key to cure MPB is to combat against BOTH dht and pgd2.

There's still other areas that need work:

Inhibition of:
DKK1
Arachidonic Acid

Upregulation of:
PGE2
CD200 Progenitor Cells
CD34 Progenitor Cells

[35YrsAfter]

Symptoms of arachidonic acid deficiency include dry, scaly and itchy skin, hair loss, dandruff, reproductive difficulties, gastrointestinal disturbances, and food intolerances.

[It's2014ComeOnAlready]

I just came across an old thread on follica from 2008 discussing a patent that talks about a treatment with a pgd2 inhibitor. So I guess they knew about pgd2 before 2012, which is when they made their announcement.

They knew 4 years earlier (maybe more) from when they made their announcement. Therefore, there is good reason not to believe everything they say. I think they're close.

[Kudu]

I just came across an old thread on follica from 2008 discussing a patent that talks about a treatment with a pgd2 inhibitor. So I guess they knew about pgd2 before 2012, which is when they made their announcement.

They knew 4 years earlier (maybe more) from when they made their announcement. Therefore, there is good reason not to believe everything they say. I think they're close.

It's possible. The problem is that since we don't know what goes on tends to make people think that nothing is going on. Look at how AA was cured out of the blue.

[Swooping]

It definitely isn't the cure. Else GPR44 antagonists would show success.

[It's2014ComeOnAlready]

It definitely isn't the cure. Else GPR44 antagonists would show success.

How do you know they haven't been successful? Follica hasn't released anything on that. Because it didn't work for asthma, doesn't mean it won't work for hair.

[Swooping]

How do you know they haven't been successful? Follica hasn't released anything on that. Because it didn't work for asthma, doesn't mean it won't work for hair.

So you think that in these clinical trials, which probably consisted of hundreds of people. Nobody suffered from AGA? Sure hair regrowth would be noted as a side effect of the medication and we would have known by now. Minoxidil was miraculously discovered this way, because it grew hair as a side effect in a clinical trial which was not hair related.

[It's2014ComeOnAlready]

So you think that in these clinical trials, which probably consisted of hundreds of people. Nobody suffered from AGA? Sure hair regrowth would be noted as a side effect of the medication and we would have known by now. Minoxidil was miraculously discovered this way, because it grew hair as a side effect in a clinical trial which was not hair related.

I honestly don't know, but neither do you. So you don't think that blocking GPR44 receptor would benefit hair growth, and this is based on what? Because you don't have any information at your fingertips? C'mon.