WCHR 2014 Presentations (Community-funded)

[Thinning87]

No one here cares about Acell. We all know you're just trying to publicize your boss. It's so obvious, have some self respect and stop trying to make it look like a conversation about Acell belongs to this thread. You're only hurting your own credibility.

[walrus]

Have a look at Dr. Jerry Cooley's ACell studies. If that isn't convincing to you, see if you can witness an ACell study conducted by a doctor having success with ACell. Seeing with your own eyes is the best hard evidence.

Are said studies published in peer reviewed journals?

[35YrsAfter]

The above post is entirely anecdotal in nature, you provide no hard evidence.

Have a look at Dr. Jerry Cooley's ACell studies. If that isn't convincing to you, see if you can witness an ACell study conducted by a doctor having success with ACell. Seeing with your own eyes is the best hard evidence.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[walrus]

The above post is entirely anecdotal in nature, you provide no hard evidence.

[35YrsAfter]

The burden of proof is not on us in this case. Where is the evidence? Were these studies published? If not, why not?

I responded to JJJJrs comment: "That's nice but there's not a single shred of evidence that ACell has any positive effect on hair."

If JJJJrs had said "I have not personally seen convincing evidence, ACell has any positive effect on hair", I would have respected that statement. His statement as posted is ludicrous. I have personally seen hair growing from extraction sites. Hyaluronic acid improves the effectiveness of ACell. So much so that, in many cases the extraction sites are extremely difficult to locate. Many of Dr. Cole's patients are physicians. Every one of them as long as I have been with Dr. Cole has opted to have ACell administered during their surgery. They are well aware of advances is regenerative medicine and understand how it is possible for some of the follicles in their donor to regenerate. We did have a patient in two weeks ago with a Ph.D. in Pharmacology that opted out of ACell and PRP. He also doesn't believe there will ever be an oral or topical cure for male pattern baldness. So everyone has their opinions.

Skeptics should read up on extracellular matrix. I have spoken with the ACell rep and the FDA is very strict on what can be said about their products. They are allowed to say it's an effective remodeling and regenerative product because studies support that, but they can't give certain specifics.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[walrus]

So you have been present at every ACell study related to follicle regeneration ever conducted, and you're here to tell us that ACell is worthless withinin the field of hair transplantation? You weren't present during our study, I doubt you were present during Dr. Jerry Cooley's or Dr. Mwamba's study. Which studies did you witness that were unsuccessful?

Chuck

The burden of proof is not on us in this case. Where is the evidence? Were these studies published? If not, why not?

[joachim]

WHERE IS DESMOND???

a lot of questions are still unanswered. it's been a months now since the conference.

[35YrsAfter]

It's possible that a good PGD2 blocker might be discovered in the next few years too, and eventually marketed. I know that Garza is working on that, and probably other people, especially after receiving that last email from dr. xu.

I agree. Those of you who have had dental work or FUE hair transplant surgery are aware that medication can be administered to have a more localized effect. In other words when they numb your mouth or your head, the rest of your body doesn't go numb as well. That's why I believe micro needling could play a role in administering an effective PGD2 blocker down the road.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[35YrsAfter]

That's nice but there's not a single shred of evidence that ACell has any positive effect on hair.

So you have been present at every ACell study related to follicle regeneration ever conducted, and you're here to tell us that ACell is worthless withinin the field of hair transplantation? You weren't present during our study, I doubt you were present during Dr. Jerry Cooley's or Dr. Mwamba's study. Which studies did you witness that were unsuccessful?

Chuck

[joachim]

This of course coincides with the wounding method... HOWEVER, donor area is not the only wounded region.. the recipient area is too! And remember, recipient area not only receives new graft from donor, but these are also placed overtop existing miniaturized follicles... so why not inject DP cells into THIS area as well potentially allowing recipient grafts, reviving old miniaturized follicles AND new follicle formation as well. TRIPLE-****ING-THREAT.

Would be really interesting how these wounds progress after injections of Replicels dermal sheath cup cells or even Histogen's growth factor injections.

i think inserting DP spheorids together with the grafts in the recipient site could be a technical problem. thd DP spheroids are not very stable. they have to be inserted carefully. if you put it together with a graft, the mechanical force would probably destroy the spheroid. the result would be 2D cells avain, or something like broken pieces of the spheroid.
injection into the donor site hole seems easier to me. the wound would also quickly close and the spheroid would be kept safely inside then. maybe in combination with ACell would be a good shot, too.
if we only could test that somehow, but there's no way if nigam is out of the game.

i see this also as a possible plan B in case it turns out that in some years bioengineered follicles implantation into bald scalp doesn't produce sufficient results because of lacking fat cells or whatever. instead of implanting the lab grown follicles into bald scalp just do a regular FUE and repair the donor sites instead. because the environment is much better in the donor area i see a better chance for lab grown follicles to grow in donor than in recipient. however, this is a worst case scenario. i still hope that once lab grown follicles are ready they will grow everywhere anyway. at least for 5 to 10 years until they die again. to me this would be an effective cure, even if i have to go for a refresh treatment every 5 to 10 years.

[hellouser]

just another thought, too:
what would happen if you extract a graft (in an FUE session), and fill the hole with a DP spheroid? would there be a greater chance of donor regeneration (even with spheroids of only 40% gene expression)? if i'm not wrong here, this isn't exactly what nigam tried. he only tried to inject 2d cells for regeneration, and some 3d spheroids into the bald recipient site.

but did anyone ever try to repair an FUE extraction hole with a DP spheroid? in theory i see a goog chance here for some regeneration... at least better as with acell or pilofocus

This of course coincides with the wounding method... HOWEVER, donor area is not the only wounded region.. the recipient area is too! And remember, recipient area not only receives new graft from donor, but these are also placed overtop existing miniaturized follicles... so why not inject DP cells into THIS area as well potentially allowing recipient grafts, reviving old miniaturized follicles AND new follicle formation as well. TRIPLE-****ING-THREAT.

Would be really interesting how these wounds progress after injections of Replicels dermal sheath cup cells or even Histogen's growth factor injections.

[Armandein]

just another thought, too:
what would happen if you extract a graft (in an FUE session), and fill the hole with a DP spheroid? would there be a greater chance of donor regeneration (even with spheroids of only 40% gene expression)? if i'm not wrong here, this isn't exactly what nigam tried. he only tried to inject 2d cells for regeneration, and some 3d spheroids into the bald recipient site.

but did anyone ever try to repair an FUE extraction hole with a DP spheroid? in theory i see a goog chance here for some regeneration... at least better as with acell or pilofocus

Fantastic idea....., surely it works

[JZA70]

Curious if RepliCel will change their method. I agree how it looked like a state of the art treatment a few years ago but now it's at the very bottom of the totem pole.

I assume if they do end up changing their method, they would have to redo clinical trials.

[sdsurfin]

Also, mark my words- replicel is going to totally change their product around, and are probably looking into the viability of injecting 3D cultured cells as well. I have no doubt that they will take their time, and eventually release a product that takes into account the current progress. No way they move forward and market their current product, its way behind the times. I think that in a decade or more, something like histogen, which injects growth factors, combined with a topical AA, combined with a stem cell injectable, will all be used in combination. some time after that, entire follicles will be grown and implanted. unfortunately, except for the topical AA, i dont think any of that is coming within the next ten years. too much testing and progress to be done. those are my predictions, may they be proven wrong It's possible that a good PGD2 blocker might be discovered in the next few years too, and eventually marketed. I know that Garza is working on that, and probably other people, especially after receiving that last email from dr. xu.

[sdsurfin]

wait a second.

i really don't want to mention his name that often, but seriously, what about nigam?

isn't he able to exactly do the protocol from jahoda/gardner and inject the 3D spheroids with 40% gene expression? and practically, doing the same thing like in the taiwan trials?
but he shouldn't dare to inject other crap like he does usually. and not mix it with donor doubling, prp, etc.
it should be a safe experiment and only follow the exact same protocol from the researchers.

am i missing something? isn't nigam able to replicate the methods exactly?
are we really supposed to wait 2 or 3 years to see the outcome of the taiwanese trials?

No more talk of Nigam, seriously. he's a hack and way behind knowledge-wise compared to the real pros.

Also, no chinese team EVER claimed 100% gene expression retention. the only thing we know about the chinese team is that they improved gene expression similarly to the other teams. they are using methods that are similar to the last presentation by the japanese guy. no one except for desmond ever claimed otherwise, and as useful and enthusiastic as he is, the dude gets all hyped up and says things that are taken out of context and inflated.


also hellouser- no one is doing a tril except for the taiwanese because it is NOT READY. get it through your head man, no one is out to slow things down or to stagnate. everyone wants progress. If you watch those presentations you can see that human DP cels are simply not making good hair yet. THe difference between the way that mouse DPs induce hair and the way that human ones do (even when gene retention techniques are used) is staggering. Before they start injecting those things into people, they need to figure out how to make them actually work well. Also, did you maybe notice that the grafting techniques that they have basically form a crazy clump of hair in the mouse skin, hairs that go every which way, and are not suitable for duplicating in a person? I certainly would not let anyone inject that shit into me the way it is being done now, and i dont know why anyone else would.

Im curious to know how the team in taiwan is doing it, but im guessing its with sick people and they are probably doing a similar grafting procedure. in any case ,dont expect to be seeing pictures of people with natural looking hair coming ou tof that. it will probably just be a little circle that they are using and will asess how well the cells induce follicles, which they will probably cut out of the patients as soon as its finished.