WCHR 2014 Presentations (Community-funded)

[Desmond84]

During these presentations, you will notice that many of them are getting great results in terms of restoring hair inductivity in the early passages of DP culturing. Not so much in the latter passages. SO I actually asked them if that is a problem and would they have enough DP produced with these early passages to completely restore a bald scalp. The answer was: "the number of DP cells cultured in these early passages is sufficient to restore hairs on a scalp who is above NW6 and even maybe NW7!"


Desmond, what do you mean with passages?

From what I remember from Uni days I'm pretty sure first passage is when your original cells divide so many times that you have to transfer some of them to a new plate to continue cell culture. So say we have 20 DP cells on a plate. After a fews days and the right conditions we have 60 DP cells and the plate is full. You then have to grab most of these cells and transfer them to a new plate and restart the division process. The cells that just got transferred to a new plate are known as Passage 1. And every time you do this again, it is called passage 2, 3 and so on...

As you go down the passages (e.g. 3, 4, 5) you start losing more and more properties of the original cell lines, kind of like photocopying the photocopy over and over...

So usually the best passages are the second and third. Now what I was referring to was that they seem to be able to culture sufficient cells in the first few passages (passage 2, 3, 4) to cover the entire balding area, which is magnificent

[35YrsAfter]

Hey guys,

Here's Dr Rei Ogawa's presentation A fascinating lecture but a little bit graphic. If you couldnt put up with it just skip ahead. The first half of his presentation is just talking about what Mechanotherapy is! The second half is about how it would be effective in hair regeneration! I really liked this presentation..it was way out from the left field and if he is onto something it may become available way sooner than other therapies as medical devices do not undergo a 3 phase trial like medicines do which is great for us

Enjoy and please leave feedback

Dr. Rei Ogawa mentioned that a tightly stretched scalp inhibits fat cell production. Most likely due to the effect of compression, like stretching a sheet of foam rubber or saran wrap downward over a mannequin head.

Observation:
"The layer of fat at the base of the skin, known as subcutaneous adipose tissue or “baby fat”, diminishes with age. Researchers have noted that fat accumulates around the healthy follicles that vigorously grow hair. In contrast, they observed a lack of fat around dormant follicles. They postulate that these fat cells serve a supportive function for the hair follicle. Conditions that inhibit hair growth, such as chemotherapy and starvation, also decrease the subcutaneous fat layer (Stenn et al 1991)."

IMO, DHT causes a whole cascade of issues, all contributing to miniaturization of susceptible hairs.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[hellouser]

Dr. Rei Ogawa mentioned that a tightly stretched scalp inhibits fat cell production. Most likely due to the effect of compression, like stretching a sheet of foam rubber or saran wrap downward over a mannequin head.

Observation:
"The layer of fat at the base of the skin, known as subcutaneous adipose tissue or “baby fat”, diminishes with age. Researchers have noted that fat accumulates around the healthy follicles that vigorously grow hair. In contrast, they observed a lack of fat around dormant follicles. They postulate that these fat cells serve a supportive function for the hair follicle. Conditions that inhibit hair growth, such as chemotherapy and starvation, also decrease the subcutaneous fat layer (Stenn et al 1991)."

IMO, DHT causes a whole cascade of issues, all contributing to miniaturization of susceptible hairs.

Is it possible to transfer fat cells by injection from one area of the body into the scalp?

[35YrsAfter]

Is it possible to transfer fat cells by injection from one area of the body into the scalp?

Some variation of fat therapy may play a future role in improving hair growth:

Yale study

Some claim that derma rolled copper peptides improve the fatty layer.


35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[sdsurfin]

Hey Des, post Dr. Lindner's next? I think we're all really keen to see the stem cell related talks.
would love to see that burning scalp one too, I wouldn't even mind hair loss so much if it wasn't itchy all the time.

[nameless]

Some variation of fat therapy may play a future role in improving hair growth:

Yale study

Some claim that derma rolled copper peptides improve the fatty layer.


35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

Who claims that derm-rolled copper peptides improve fatty layer?
I ask because Pilox claims to put copper (and zinc) ions into the scalp by way of some kind of electrically charged roller blades but the blades dont actually cut through the skin I' m told.

[hellouser]

Some variation of fat therapy may play a future role in improving hair growth:

Yale study

Some claim that derma rolled copper peptides improve the fatty layer

Hmmm....

What if part of the reason why follicles did NOT grow on the scalp in balding areas when Aderans tried it or during Replicels phase I trials is due to this?

Perhaps if they injected the cells into areas where fatty tissue exists we could see growth of new follicles and use those to transplant into balding areas along WITH the fatty tissue?

But having said that, is the fatty tissue absolutely necessary?

[joachim]

i'm wondering why this "fat tissue" problem came up so late. would that really mean that if one of the researchers is able to induce new follicles then the results would highly depend on the fat tissue? what would happen without fat tissue? is there a chance that the induced or lab-grown implanted follicle can still survive for about some years? (let's say at least 5 years)

because if a bald scalp really lacks a lot of fat tissue (which seems to be the case from what i can read from the latest talks), then we have soms serious problems here. then the cure is really 3 decades away.

would injecting fat cells into the scalp even be possible? would the fat stay there for years?

[TheSwingingGate]

Fat grafting (transfers) are already very common in Cosmetic Surgery. Hopefully it would be a similar procedure for the scalp.

[hellouser]

i'm wondering why this "fat tissue" problem came up so late. would that really mean that if one of the researchers is able to induce new follicles then the results would highly depend on the fat tissue? what would happen without fat tissue? is there a chance that the induced or lab-grown implanted follicle can still survive for about some years? (let's say at least 5 years)

because if a bald scalp really lacks a lot of fat tissue (which seems to be the case from what i can read from the latest talks), then we have soms serious problems here. then the cure is really 3 decades away.

would injecting fat cells into the scalp even be possible? would the fat stay there for years?

You know... it very well might pose a giant shitstorm of a problem.

Remember Aderans' results? Here's a before/after shot:



Would these poor results around ONLY the edge of existing follicles be due to the fact that fatty tissue was still there? Did they even try to inject their cells into areas where fatty tissue was present? Consider this:

Move all/most follicles from sides/back of head to top with fatty tissue and inject entire back/side areas with DP cells (assuming they'll grow there).

However.. if the fatty tissue is still connected to the follicle when being transplanted... does it stick to it permanently after being implanted?

[hellouser]

Fat grafting (transfers) are already very common in Cosmetic Surgery. Hopefully it would be a similar procedure for the scalp.

Questions!

1) Is fat grafting expensive?
2) Would injecting fat grafts into the scalp before injecting DP/DSC or other follicle stem cells be beneficial?
3) Has anyone injected fat grafts into the scalp while on Fin or Minox? Perhaps growth factors from Histogen would help?
4) When harvested and if implanted into the scalp, how would it be affected by weight loss programs? Would the fat be burned off?

[35YrsAfter]

i'm wondering why this "fat tissue" problem came up so late. would that really mean that if one of the researchers is able to induce new follicles then the results would highly depend on the fat tissue? what would happen without fat tissue? is there a chance that the induced or lab-grown implanted follicle can still survive for about some years? (let's say at least 5 years)

because if a bald scalp really lacks a lot of fat tissue (which seems to be the case from what i can read from the latest talks), then we have soms serious problems here. then the cure is really 3 decades away.

would injecting fat cells into the scalp even be possible? would the fat stay there for years?

I think fat is a contributing factor but consider that hair follicles are transplanted from the back and sides of the head to slick bald areas on top of the head. Generally the hair has similar longevity transplanted to the bald scalp as it would have in its original location.

Dr. Cole and one other hair transplant doctor I'm aware of are beginning to use a new regenerative product called AmnioFix. It may replace PRP and possibly even ACell. Great progress is being made in nearly every area of medicine.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[hellouser]

I just called a clinic and asked about fat grafting for the entire face (under eyes, cheeks and chin) and the entire procedure lasts about 2 hours and costs about $4,900 at the following locale http://www.myplasticsurgerytoronto.com/

Seeing how many of us are willing to spend 10+ thousands of dollars on hair restoration, this wouldn't really be that big of a dent for us. But it really does raise an interesting topic.

[TheSwingingGate]

Hell,

I don't have the answer to your questions.
You raise a particularly interesting question in #4.
In my years of body fat lowering/raising and working out, it makes me wonder if I exacerbated hair loss with either androgen raising or body fat lowering.

Of course, every time I think this way, I think of Jay Cutler who has more hair than I did at 12 years old, and is multi time Mr. Olympia!

[hellouser]

Hell,

I don't have the answer to your questions.
You raise a particularly interesting question in #4.
In my years of body fat lowering/raising and working out, it makes me wonder if I exacerbated hair loss with either androgen raising or body fat lowering.

Of course, every time I think this way, I think of Jay Cutler who has more hair than I did at 12 years old, and is multi time Mr. Olympia!

On the flip side, I dont work out at all and have lost a significant amount of hair. What's odd is that I used to play a lot of basketball in my teens but my 20s I was completely inactive.