WCHR 2014 Presentations (Community-funded)

[fuzzyballs]

So suggest a solution.

Also how did you get your avatar to animate - I tried uploading an animated gif but to no avail.

[hairquest]

Desmond is doing a great job and i thank him for that. but it's sad to see that all of the solution are still year's away...
Not a single one are close or for the year to come...

[joachim]

Hey Hell

Yes I did. I will email him tonight.
Thank you

Joachim, I did go to the talk but didn't record it. Really sorry brother. I got caught up chatting with a researcher and didn't make it to the room in time to record the talk. I'll give you a summary of what was press Ted tonight though. Plz remind me. Cheers.

Jahodas team is presenting in about 2 hours. Arashi I've got the gear ready brother. I'm recording it no matter what lol

ok, no problem.
maybe they have a flyer with some basic info and some pics on it.
take it with you if you find something like that...
would just like to know what it's about, although not a priority of course.

[35YrsAfter]

I'd be most willing to put my money into Histogen.

I think equity crowd funding is interesting.

I'd even put money into funding accelerating Pilofocus and teaching it everywhere (if it turns out to be a good new standard in HT technology).

How does that sound to you bro?

I want a cure as much as the rest of you guys but I wouldn't give any of my hard-earned money to any of the hair research crowd. They can get their funding from traditional sources.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[hellouser]

Idea:

If we funded a research team through crowdfunding, could we not have an agreement that the treatment be released in a less regulation country that allows the use of stem cells as treatment? This would not only serve as a testbed for safety as it'd allow people to actually USE the treatment in larger numbers (no thanks to the FDA as it's objective is the exact opposite) as well as generate revenue to continue funding of clinical trials in strict jurisdictions (europe, USA, etc).

Thoughts????

[JZA70]

We shouldn't have to wait years and years for clinical trials.

What Lauster is doing "could" be done by ourselves with some crowdfunding and a small lab area with equipment.

We only need them to show us it can be done. Although it may seem like a long shot, I think its very possible.

We have to take the initiative to get things done ourselves, which is exactly what this thread is all about.

Once they spill the beans on how their technique works, we should really consider giving it a go ourselves.

[joachim]

Idea:

If we funded a research team through crowdfunding, could we not have an agreement that the treatment be released in a less regulation country that allows the use of stem cells as treatment? This would not only serve as a testbed for safety as it'd allow people to actually USE the treatment in larger numbers (no thanks to the FDA as it's objective is the exact opposite) as well as generate revenue to continue funding of clinical trials in strict jurisdictions (europe, USA, etc).

Thoughts????

totally agreed.
would be interesting if this could be a possible way for lausters team.
if we could achieve such a deal, we should put the 20 million (or even more if necessary) into their research. as soon as proof of concept and safety is done, the technology should be made available. i don't know what desmond saw on their slides and pics, but it looks to me that proof of concept is already here, and might need some optimization to increase consisteny and efficacy. with safety i don't expect any troubles. however, a phase1 safety trial should be done. this takes 1 year maximum. in total it should not take more than 3 years maybe to enable some good multiplication (at worst case by factor 2 only, which would be doubling then, and already a cure if you go multiple times).

[PaddyBateman]

I like the idea of crowdfunding, but would the "investors" into this scheme get a % of the future profits of a successful outcome ? Otherwise it's a free option for those that accept the $.

[joachim]

hellouser: as soon as we got some basic info from desmond to see whats still missing to the puzzle we should seriously try to get in contact with lindner and discuss some further steps.
they also should tell us if money could accelerate the process or if there are still technical/biological hurdles to solve. if money is no problem at all for them because they have enough funding from germany (because it's a university-based research) or from other private investors, then we know at least that funding into other stuff would make more sense at the moment. then we can decide if cots should be evaluated further, or xu, or tsuji, histogen and others.

[joachim]

if you think about lauster/lindners progress so far it looks really good.

they showed in early 2010 that they created a full follicle which produced a hair in vitro already, in the petri dish / biochip. not sure if genetic properties were the same then or if this was one of the hurdles to work on.
this follicle was created with isolated existing cells probably, but not with multiplied cells i assume.
so the dp culturing problem was probably also present at that time.

desmond mentioned they had moved on at a much faster pace than he thought, regarding dp culturing. in the meantime also a lot of other researchers cracked the dp stuff, more or less. (maybe one method of culturing is more effective than other ones).

so i assume dp culturing is practically solved now. means that hair can be produced in vitro with the same genetic expression. as the follicle already produces hair in the dish, there will never be angle problems during implantation. i hope they implanted such a follicle already in a human. this is what i call proof of concept.

the next step would be the automatic mass production in bio reactors, so that many hairs are produced simultaneously and ready for implanting. i think that this could be the actual development they are still working on. because, such a reactor doesn't exist today, so they have to develop it from scratch. they are maybe even working with an external partner who is responsible for the mechanical and electronic design of the whole reactor machine. and if we can accelerate that by pumping some money into the development, this would be great.

when the reactor is ready, phase 1 would be the next logical step.

[sdsurfin]

if you think about lauster/lindners progress so far it looks really good.

they showed in early 2010 that they created a full follicle which produced a hair in vitro already, in the petri dish / biochip. not sure if genetic properties were the same then or if this was one of the hurdles to work on.
this follicle was created with isolated existing cells probably, but not with multiplied cells i assume.
so the dp culturing problem was probably also present at that time.

desmond mentioned they had moved on at a much faster pace than he thought, regarding dp culturing. in the meantime also a lot of other researchers cracked the dp stuff, more or less. (maybe one method of culturing is more effective than other ones).




so i assume dp culturing is practically solved now. means that hair can be produced in vitro with the same genetic expression. as the follicle already produces hair in the dish, there will never be angle problems during implantation. i hope they implanted such a follicle already in a human. this is what i call proof of concept.

the next step would be the automatic mass production in bio reactors, so that many hairs are produced simultaneously and ready for implanting. i think that this could be the actual development they are still working on. because, such a reactor doesn't exist today, so they have to develop it from scratch. they are maybe even working with an external partner who is responsible for the mechanical and electronic design of the whole reactor machine. and if we can accelerate that by pumping some money into the development, this would be great.

when the reactor is ready, phase 1 would be the next logical step.

Once again ignoring most of the info we have received recently. The DP culturing problem is sort of solved, but they cannot make new DP cells from scratch. this is what is needed in order to create many new follicles. Communication with Dr. Xu has revealed that making a functioning follicle from scratch is certainly possible, but no one is close to doing that yet and most people don't have enough funding. all they are able to do is form hair-like strands when they amass certain cells, like they have been able to do for a while now. this is not the same as building an entire healthy organ. Much less thousands of them. The bioreactor is not a machine that makes follicles. it is an environment where you can keep something like a hair follicle alive. Basically a compartment. I mean this is all interesting stuff, but it's in the same realm as making any other organ from scratch and using it, still decades away. I also think that balding is something that affects the entire scalp, from my own experience it is an inflammatory and immune response, and everything from the fat cells to the skin cells to the follicles are affected. This is why it's easy to grow new hair with stem cells on mice, because it's not as hostile an environment. I don't think anyone will be able to implant new stem cells or follicles into balding scalp without running into a whole array of problems. transplants work because they implant a whole cut of non balding environment with the graft. I'm sure that in the not too distant future, stem cell tech will be able to make follicles AND surrounding tissue from scratch and implant all of it, but jesus we are so so far from that in realistic terms. I think maybe our grandsons won't have to worry, but by then the world is gonna be a shitshow anyway. might as well just be like our granddads and be bald and the biggest men we can be despite the fact.

[JZA70]

You make a lot of strong points SD. Awesome post.

[Arashi]

Once again ignoring most of the info we have received recently. The DP culturing problem is sort of solved, but they cannot make new DP cells from scratch.

Tsusji lab and Jahoda both did that

[hellouser]

Tsusji lab and Jahoda both did that

And from Desmond's talk with Dr. Lindner, it seems like Dr. Lauster's team overcame the DP cells problem as well.

Funny how we though Dr. Lauster shelved the whole project and then Desmond drops a bomb on us that they've purposely been quiet all these years.

[nameless]

hellouser: as soon as we got some basic info from desmond to see whats still missing to the puzzle we should seriously try to get in contact with lindner and discuss some further steps.
they also should tell us if money could accelerate the process or if there are still technical/biological hurdles to solve. if money is no problem at all for them because they have enough funding from germany (because it's a university-based research) or from other private investors, then we know at least that funding into other stuff would make more sense at the moment. then we can decide if cots should be evaluated further, or xu, or tsuji, histogen and others.

I think we should get in touch with Linder but we should also get in touch with Cotseralis and others. We should find out if we crowdfund if they would let us either be subjects who get certain treatment (no double-blinding) or if they will agree to let the doctors use the treatment in just one country where the treatment would be legal so that those of us with the gumption could go and get the treatment. I would not care about owning a piece of the right to the company but if they offered that then I would not reject it. Mostly I would want them to accept that they would allow a doctor or doctors in one specific country to do the treatment as long as it's legal to do the treatment in that one country.

If they won't agree to this then I don't think that there's any reason to try t crowdfund for them.